Diet-Induced Obesity Impairs Outcomes and Induces Multi-Factorial Deficiencies in Effector T Cell Responses Following Anti-CTLA-4 Combinatorial Immunotherapy in Renal Tumor-Bearing Mice

Diet-Induced Obesity Impairs Outcomes and Induces Multi-Factorial Deficiencies in Effector T Cell Responses Following Anti-CTLA-4 Combinatorial Immunotherapy in Renal Tumor-Bearing Mice

Associations between modifiable factors and the efficacy of cancer immunotherapies remain uncertain. We found previously that diet-induced obesity (DIO) reduces the efficacy of an immunotherapy consisting of adenovirus-encoded TRAIL plus CpG oligonucleotide (AdT/CpG) in mice with renal tumors. To el...

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Bibliographic Details
Main Authors: William J. Turbitt, Shannon K. Boi, Justin T. Gibson, Rachael M. Orlandella, Lyse A. Norian
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Cancers
Subjects:
diet-induced obesity
cancer therapy
immunotherapy
T cells
Online Access:https://www.mdpi.com/2072-6694/13/10/2295

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