Real‐World clinical features and survival outcomes associated with primary gastrointestinal natural killer/T‐cell lymphoma from 1999 to 2020
Abstract Background Primary gastrointestinal natural killer (NK)/T‐cell lymphoma (PGINKTL) is a rare T‐/NK‐cell lymphoma subtype, and the clinical features and survival outcomes remain largely unknown. Methods To summarize the clinical features and survival outcomes of PGINKTL, PGINKTL cases diagnos...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-02-01
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| Series: | Cancer Medicine |
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| Online Access: | https://doi.org/10.1002/cam4.5136 |
| _version_ | 1797903118682292224 |
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| author | Yang Chunli Jiang Ming Ma Ziyan Ji Jie Lv Shuli Huang Jie Wu Yu Xu Caigang Zou Liqun |
| author_facet | Yang Chunli Jiang Ming Ma Ziyan Ji Jie Lv Shuli Huang Jie Wu Yu Xu Caigang Zou Liqun |
| author_sort | Yang Chunli |
| collection | DOAJ |
| description | Abstract Background Primary gastrointestinal natural killer (NK)/T‐cell lymphoma (PGINKTL) is a rare T‐/NK‐cell lymphoma subtype, and the clinical features and survival outcomes remain largely unknown. Methods To summarize the clinical features and survival outcomes of PGINKTL, PGINKTL cases diagnosed at our hospital from May 1999 to December 2020 were reviewed; and the clinical data, information on treatment strategies, and survival were collected. Survival analysis was performed using the Kaplan–Meier method and multivariable Cox proportional hazards regression. We constructed a nomogram to visualize the survival prediction of PGINKTL. The discriminative ability and calibration of the nomogram for prediction were tested using the concordance index (C‐index) and calibration plots. Results The cohort included 81 cases, the median age was 36 years (range, 7–80 years), and the male‐to‐female ratio was 1.7:1. The most common clinical symptom at the time of diagnosis was abdominal pain (71.6%). The most common lesion site was the colon (59.3%). During a median follow‐up period of 37.7 months, the median overall survival (OS) time of 81 patients was 4.0 months (95% confidence interval [CI], 3.1–4.9 months), and the 2‐year OS rate was 30.7% (95% CI, 20.3%–40.1%). The multivariate analyses indicated that patients with an Eastern Cooperative Oncology Group (ECOG) performance status (PS) score ≥2, serum lactic dehydrogenase (LDH) level ≥ the upper limit normal (ULN), and perforation had worse OS. We used these data to establish a nomogram to predict survival for PGINKTL. The nomogram displayed good accuracy, with a C‐index of 0.726. Conclusion The clinical features and poor outcomes of PGINKTL, which is a rare and fatal lymphoma type, are presented. The proposed nomogram provides an individualized estimate of survival for these patients. In the future, the study focused on exploring a better treatment strategy to improve survival is required in PGINKTL. |
| first_indexed | 2024-04-10T09:27:55Z |
| format | Article |
| id | doaj.art-a90f313f2d5b432789575de1ded98a4d |
| institution | Directory Open Access Journal |
| issn | 2045-7634 |
| language | English |
| last_indexed | 2024-04-10T09:27:55Z |
| publishDate | 2023-02-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cancer Medicine |
| spelling | doaj.art-a90f313f2d5b432789575de1ded98a4d2023-02-19T18:54:07ZengWileyCancer Medicine2045-76342023-02-011232614262310.1002/cam4.5136Real‐World clinical features and survival outcomes associated with primary gastrointestinal natural killer/T‐cell lymphoma from 1999 to 2020Yang Chunli0Jiang Ming1Ma Ziyan2Ji Jie3Lv Shuli4Huang Jie5Wu Yu6Xu Caigang7Zou Liqun8State Key Laboratory of Biotherapy and Cancer Center West China Hospital, Sichuan University Chengdu ChinaDepartment of Oncology West China Hospital, Sichuan University Chengdu ChinaDepartment of Global Public Health Karolinska Institute Stockholm SwedenDepartment of Hematology West China Hospital, Sichuan University Chengdu ChinaLymphoma Project Group West China Hospital, Sichuan University Chengdu ChinaDepartment of Hematology West China Hospital, Sichuan University Chengdu ChinaDepartment of Hematology West China Hospital, Sichuan University Chengdu ChinaDepartment of Hematology West China Hospital, Sichuan University Chengdu ChinaState Key Laboratory of Biotherapy and Cancer Center West China Hospital, Sichuan University Chengdu ChinaAbstract Background Primary gastrointestinal natural killer (NK)/T‐cell lymphoma (PGINKTL) is a rare T‐/NK‐cell lymphoma subtype, and the clinical features and survival outcomes remain largely unknown. Methods To summarize the clinical features and survival outcomes of PGINKTL, PGINKTL cases diagnosed at our hospital from May 1999 to December 2020 were reviewed; and the clinical data, information on treatment strategies, and survival were collected. Survival analysis was performed using the Kaplan–Meier method and multivariable Cox proportional hazards regression. We constructed a nomogram to visualize the survival prediction of PGINKTL. The discriminative ability and calibration of the nomogram for prediction were tested using the concordance index (C‐index) and calibration plots. Results The cohort included 81 cases, the median age was 36 years (range, 7–80 years), and the male‐to‐female ratio was 1.7:1. The most common clinical symptom at the time of diagnosis was abdominal pain (71.6%). The most common lesion site was the colon (59.3%). During a median follow‐up period of 37.7 months, the median overall survival (OS) time of 81 patients was 4.0 months (95% confidence interval [CI], 3.1–4.9 months), and the 2‐year OS rate was 30.7% (95% CI, 20.3%–40.1%). The multivariate analyses indicated that patients with an Eastern Cooperative Oncology Group (ECOG) performance status (PS) score ≥2, serum lactic dehydrogenase (LDH) level ≥ the upper limit normal (ULN), and perforation had worse OS. We used these data to establish a nomogram to predict survival for PGINKTL. The nomogram displayed good accuracy, with a C‐index of 0.726. Conclusion The clinical features and poor outcomes of PGINKTL, which is a rare and fatal lymphoma type, are presented. The proposed nomogram provides an individualized estimate of survival for these patients. In the future, the study focused on exploring a better treatment strategy to improve survival is required in PGINKTL.https://doi.org/10.1002/cam4.5136extranodal NK/T‐cell lymphomagastrointestinalnomogramprognosissurvival |
| spellingShingle | Yang Chunli Jiang Ming Ma Ziyan Ji Jie Lv Shuli Huang Jie Wu Yu Xu Caigang Zou Liqun Real‐World clinical features and survival outcomes associated with primary gastrointestinal natural killer/T‐cell lymphoma from 1999 to 2020 Cancer Medicine extranodal NK/T‐cell lymphoma gastrointestinal nomogram prognosis survival |
| title | Real‐World clinical features and survival outcomes associated with primary gastrointestinal natural killer/T‐cell lymphoma from 1999 to 2020 |
| title_full | Real‐World clinical features and survival outcomes associated with primary gastrointestinal natural killer/T‐cell lymphoma from 1999 to 2020 |
| title_fullStr | Real‐World clinical features and survival outcomes associated with primary gastrointestinal natural killer/T‐cell lymphoma from 1999 to 2020 |
| title_full_unstemmed | Real‐World clinical features and survival outcomes associated with primary gastrointestinal natural killer/T‐cell lymphoma from 1999 to 2020 |
| title_short | Real‐World clinical features and survival outcomes associated with primary gastrointestinal natural killer/T‐cell lymphoma from 1999 to 2020 |
| title_sort | real world clinical features and survival outcomes associated with primary gastrointestinal natural killer t cell lymphoma from 1999 to 2020 |
| topic | extranodal NK/T‐cell lymphoma gastrointestinal nomogram prognosis survival |
| url | https://doi.org/10.1002/cam4.5136 |
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