Comparison of the Relative Diagnostic Performance of [68Ga]Ga-DOTA-FAPI-04 and [18F]FDG PET/CT for the Detection of Bone Metastasis in Patients With Different Cancers
PurposeThe present retrospective analysis sought to compare the relative diagnostic efficacy of [68Ga]Ga-DOTA-FAPI-04 to that of [18F]FDG PET/CT as a means of detecting bone metastases in patients with a range of cancer types.MaterialsIn total, 30 patients with bone metastases associated with differ...
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| Format: | Article |
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Frontiers Media S.A.
2021-09-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2021.737827/full |
| _version_ | 1828916105440133120 |
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| author | Junhao Wu Junhao Wu Junhao Wu Yingwei Wang Yingwei Wang Yingwei Wang Taiping Liao Taiping Liao Taiping Liao Zijuan Rao Zijuan Rao Zijuan Rao Weidong Gong Weidong Gong Weidong Gong Lei Ou Lei Ou Lei Ou Yue Chen Yue Chen Yue Chen Chunyin Zhang Chunyin Zhang Chunyin Zhang |
| author_facet | Junhao Wu Junhao Wu Junhao Wu Yingwei Wang Yingwei Wang Yingwei Wang Taiping Liao Taiping Liao Taiping Liao Zijuan Rao Zijuan Rao Zijuan Rao Weidong Gong Weidong Gong Weidong Gong Lei Ou Lei Ou Lei Ou Yue Chen Yue Chen Yue Chen Chunyin Zhang Chunyin Zhang Chunyin Zhang |
| author_sort | Junhao Wu |
| collection | DOAJ |
| description | PurposeThe present retrospective analysis sought to compare the relative diagnostic efficacy of [68Ga]Ga-DOTA-FAPI-04 to that of [18F]FDG PET/CT as a means of detecting bone metastases in patients with a range of cancer types.MaterialsIn total, 30 patients with bone metastases associated with different underlying malignancies were retrospectively enrolled. All patients had undergone [68Ga]Ga-DOTA-FAPI-04 and [18F]FDG PET/CT, and the McNemar test was used to compare the relative diagnostic performance of these two imaging modalities. The maximum standard uptake value (SUVmax) was used to quantify radiotracer uptake by metastatic lesions, with the relative uptake associated with these two imaging strategies being compared via the Mann-Whitney U test. The cohort was further respectively divided into two (osteolytic and osteoblastic bone metastases) and three clinical subgroups (lung cancer, thyroid cancer, and liver cancer).Results[68Ga]Ga-DOTA-FAPI-04 PET/CT was found to be significantly more sensitive as a means of diagnosing bone metastases relative to [18F]FDG PET/CT ([109/109] 100% vs [89/109] 81.7%; P< 0.01), consistent with the significantly increased uptake of [68Ga]Ga-DOTA-FAPI-04 by these metastatic lesions relative to that of [18F]FDG (n=109, median SUVmax, 9.1 vs. 4.5; P< 0.01). [68Ga]Ga-DOTA-FAPI-04 accumulation was significantly higher than that of [18F]FDG in both osteolytic (n=66, median SUVmax, 10.6 vs 6.1; P < 0.01), and osteoblastic metastases (n=43, median SUVmax, 7.7 vs 3.7; P < 0.01). [68Ga]Ga-DOTA-FAPI-04 uptakes were significantly higher than that of [18F]FDG in bone metastases from lung cancer (n = 62, median SUVmax, 10.7 vs 5.2; P < 0.01), thyroid cancer (n = 18, median SUVmax, 5.65 vs 2.1; P < 0.01) and liver cancer (n = 12, median SUVmax, 5.65 vs 3.05; P < 0.01). However, [68Ga]Ga-DOTA-FAPI-04 detected 10 false-positive lesions, while only 5 false-positive were visualized by [18F]FDG PET/CT.Conclusion[68Ga]Ga-DOTA-FAPI-04 PET/CT exhibits excellent diagnostic performance as a means of detecting bone metastases, and is superior to [18F]FDG PET/CT in this diagnostic context. Furthermore, [68Ga]Ga-DOTA-FAPI-04 tracer uptake levels are higher than those of [18F]FDG for most bone metastases. However, owing to the potential for false-positive bone lesions, it is critical that physicians interpret all CT findings with caution to ensure diagnostic accuracy. |
| first_indexed | 2024-12-13T20:26:41Z |
| format | Article |
| id | doaj.art-a90fbdc5c5364dd2a335414c1f21e9cd |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-13T20:26:41Z |
| publishDate | 2021-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-a90fbdc5c5364dd2a335414c1f21e9cd2022-12-21T23:32:33ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2021-09-011110.3389/fonc.2021.737827737827Comparison of the Relative Diagnostic Performance of [68Ga]Ga-DOTA-FAPI-04 and [18F]FDG PET/CT for the Detection of Bone Metastasis in Patients With Different CancersJunhao Wu0Junhao Wu1Junhao Wu2Yingwei Wang3Yingwei Wang4Yingwei Wang5Taiping Liao6Taiping Liao7Taiping Liao8Zijuan Rao9Zijuan Rao10Zijuan Rao11Weidong Gong12Weidong Gong13Weidong Gong14Lei Ou15Lei Ou16Lei Ou17Yue Chen18Yue Chen19Yue Chen20Chunyin Zhang21Chunyin Zhang22Chunyin Zhang23Department of Nuclear Medicine, The Affiliated Hospital, Southwest Medical University, Luzhou, ChinaNuclear Medicine and Molecular Imaging Key Laboratory of Sichuan Province, Luzhou, ChinaAcademician (Expert) Workstation of Sichuan Province, Luzhou, ChinaDepartment of Nuclear Medicine, The Affiliated Hospital, Southwest Medical University, Luzhou, ChinaNuclear Medicine and Molecular Imaging Key Laboratory of Sichuan Province, Luzhou, ChinaAcademician (Expert) Workstation of Sichuan Province, Luzhou, ChinaDepartment of Nuclear Medicine, The Affiliated Hospital, Southwest Medical University, Luzhou, ChinaNuclear Medicine and Molecular Imaging Key Laboratory of Sichuan Province, Luzhou, ChinaAcademician (Expert) Workstation of Sichuan Province, Luzhou, ChinaDepartment of Nuclear Medicine, The Affiliated Hospital, Southwest Medical University, Luzhou, ChinaNuclear Medicine and Molecular Imaging Key Laboratory of Sichuan Province, Luzhou, ChinaAcademician (Expert) Workstation of Sichuan Province, Luzhou, ChinaDepartment of Nuclear Medicine, The Affiliated Hospital, Southwest Medical University, Luzhou, ChinaNuclear Medicine and Molecular Imaging Key Laboratory of Sichuan Province, Luzhou, ChinaAcademician (Expert) Workstation of Sichuan Province, Luzhou, ChinaDepartment of Nuclear Medicine, The Affiliated Hospital, Southwest Medical University, Luzhou, ChinaNuclear Medicine and Molecular Imaging Key Laboratory of Sichuan Province, Luzhou, ChinaAcademician (Expert) Workstation of Sichuan Province, Luzhou, ChinaDepartment of Nuclear Medicine, The Affiliated Hospital, Southwest Medical University, Luzhou, ChinaNuclear Medicine and Molecular Imaging Key Laboratory of Sichuan Province, Luzhou, ChinaAcademician (Expert) Workstation of Sichuan Province, Luzhou, ChinaDepartment of Nuclear Medicine, The Affiliated Hospital, Southwest Medical University, Luzhou, ChinaNuclear Medicine and Molecular Imaging Key Laboratory of Sichuan Province, Luzhou, ChinaAcademician (Expert) Workstation of Sichuan Province, Luzhou, ChinaPurposeThe present retrospective analysis sought to compare the relative diagnostic efficacy of [68Ga]Ga-DOTA-FAPI-04 to that of [18F]FDG PET/CT as a means of detecting bone metastases in patients with a range of cancer types.MaterialsIn total, 30 patients with bone metastases associated with different underlying malignancies were retrospectively enrolled. All patients had undergone [68Ga]Ga-DOTA-FAPI-04 and [18F]FDG PET/CT, and the McNemar test was used to compare the relative diagnostic performance of these two imaging modalities. The maximum standard uptake value (SUVmax) was used to quantify radiotracer uptake by metastatic lesions, with the relative uptake associated with these two imaging strategies being compared via the Mann-Whitney U test. The cohort was further respectively divided into two (osteolytic and osteoblastic bone metastases) and three clinical subgroups (lung cancer, thyroid cancer, and liver cancer).Results[68Ga]Ga-DOTA-FAPI-04 PET/CT was found to be significantly more sensitive as a means of diagnosing bone metastases relative to [18F]FDG PET/CT ([109/109] 100% vs [89/109] 81.7%; P< 0.01), consistent with the significantly increased uptake of [68Ga]Ga-DOTA-FAPI-04 by these metastatic lesions relative to that of [18F]FDG (n=109, median SUVmax, 9.1 vs. 4.5; P< 0.01). [68Ga]Ga-DOTA-FAPI-04 accumulation was significantly higher than that of [18F]FDG in both osteolytic (n=66, median SUVmax, 10.6 vs 6.1; P < 0.01), and osteoblastic metastases (n=43, median SUVmax, 7.7 vs 3.7; P < 0.01). [68Ga]Ga-DOTA-FAPI-04 uptakes were significantly higher than that of [18F]FDG in bone metastases from lung cancer (n = 62, median SUVmax, 10.7 vs 5.2; P < 0.01), thyroid cancer (n = 18, median SUVmax, 5.65 vs 2.1; P < 0.01) and liver cancer (n = 12, median SUVmax, 5.65 vs 3.05; P < 0.01). However, [68Ga]Ga-DOTA-FAPI-04 detected 10 false-positive lesions, while only 5 false-positive were visualized by [18F]FDG PET/CT.Conclusion[68Ga]Ga-DOTA-FAPI-04 PET/CT exhibits excellent diagnostic performance as a means of detecting bone metastases, and is superior to [18F]FDG PET/CT in this diagnostic context. Furthermore, [68Ga]Ga-DOTA-FAPI-04 tracer uptake levels are higher than those of [18F]FDG for most bone metastases. However, owing to the potential for false-positive bone lesions, it is critical that physicians interpret all CT findings with caution to ensure diagnostic accuracy.https://www.frontiersin.org/articles/10.3389/fonc.2021.737827/fullbone metastases[68Ga]Ga-DOTA-FAPI-04[18F]FDGPET/CTcancer |
| spellingShingle | Junhao Wu Junhao Wu Junhao Wu Yingwei Wang Yingwei Wang Yingwei Wang Taiping Liao Taiping Liao Taiping Liao Zijuan Rao Zijuan Rao Zijuan Rao Weidong Gong Weidong Gong Weidong Gong Lei Ou Lei Ou Lei Ou Yue Chen Yue Chen Yue Chen Chunyin Zhang Chunyin Zhang Chunyin Zhang Comparison of the Relative Diagnostic Performance of [68Ga]Ga-DOTA-FAPI-04 and [18F]FDG PET/CT for the Detection of Bone Metastasis in Patients With Different Cancers Frontiers in Oncology bone metastases [68Ga]Ga-DOTA-FAPI-04 [18F]FDG PET/CT cancer |
| title | Comparison of the Relative Diagnostic Performance of [68Ga]Ga-DOTA-FAPI-04 and [18F]FDG PET/CT for the Detection of Bone Metastasis in Patients With Different Cancers |
| title_full | Comparison of the Relative Diagnostic Performance of [68Ga]Ga-DOTA-FAPI-04 and [18F]FDG PET/CT for the Detection of Bone Metastasis in Patients With Different Cancers |
| title_fullStr | Comparison of the Relative Diagnostic Performance of [68Ga]Ga-DOTA-FAPI-04 and [18F]FDG PET/CT for the Detection of Bone Metastasis in Patients With Different Cancers |
| title_full_unstemmed | Comparison of the Relative Diagnostic Performance of [68Ga]Ga-DOTA-FAPI-04 and [18F]FDG PET/CT for the Detection of Bone Metastasis in Patients With Different Cancers |
| title_short | Comparison of the Relative Diagnostic Performance of [68Ga]Ga-DOTA-FAPI-04 and [18F]FDG PET/CT for the Detection of Bone Metastasis in Patients With Different Cancers |
| title_sort | comparison of the relative diagnostic performance of 68ga ga dota fapi 04 and 18f fdg pet ct for the detection of bone metastasis in patients with different cancers |
| topic | bone metastases [68Ga]Ga-DOTA-FAPI-04 [18F]FDG PET/CT cancer |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2021.737827/full |
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