In vivo antitumor effects of carboxymethyl chitosan-conjugated triptolide after oral administration

In vivo antitumor effects of carboxymethyl chitosan-conjugated triptolide after oral administration

The purpose of this study is to evaluate in vitro and in vivo antitumor efficacy and subacute toxicity of triptolide (TP) prodrug, a conjugate between TP and carboxymethyl chitosan (CC). The CCTP conjugate contained 4∼ wt % TP and displayed excellent aqueous solubility (5 mg/mL) as compared to the n...

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Bibliographic Details
Main Authors: Huahui Zeng, Xin Zhu, Qikang Tian, Yinyin Yan, Lan Zhang, Min Yan, Ruiqin Li, Xiaofang Li, Guoqiang Wang, Jinlian Ma, Yufang Su, Xiangbo Zhang, Linyu Ma, Zhenqiang Zhang, Xiangxiang Wu
Format: Article
Language:English
Published: Taylor & Francis Group 2020-01-01
Series:Drug Delivery
Subjects:
triptolide
carboxymethyl chitosan
oral administration
pancreatic cancer
toxicity
Online Access:http://dx.doi.org/10.1080/10717544.2020.1770370

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