Morphometric vertebral fracture risk in women with postsurgical hypoparathyroidism
IntroductionHypoparathyroidism (HP) is a rare endocrine disease and there are little data available on the risk of fragility fractures in these patients. PTH deficiency results in a positive bone balance with higher bone mass in all skeletal sites. However, whether these structural and dynamic skele...
| Main Authors: | , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-12-01
|
| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2022.948435/full |
| _version_ | 1797978714880868352 |
|---|---|
| author | Catarina Brasil d’Alva André Rodrigues Façanha Barreto Marcello H. Nogueira-Barbosa Caio César Cavalcante Arruda Áurea Maíla Albuquerque Débora Mota Cordeiro Praciano Rodrigo Ponte Viana Daniel Duarte Gadelha Antônio Brazil Viana Jr Ilana Marques Moreira Francisco José Rodrigues de Moura Filho Ana Flávia Torquato de Araújo Junqueira Renan Magalhães Montenegro Jr |
| author_facet | Catarina Brasil d’Alva André Rodrigues Façanha Barreto Marcello H. Nogueira-Barbosa Caio César Cavalcante Arruda Áurea Maíla Albuquerque Débora Mota Cordeiro Praciano Rodrigo Ponte Viana Daniel Duarte Gadelha Antônio Brazil Viana Jr Ilana Marques Moreira Francisco José Rodrigues de Moura Filho Ana Flávia Torquato de Araújo Junqueira Renan Magalhães Montenegro Jr |
| author_sort | Catarina Brasil d’Alva |
| collection | DOAJ |
| description | IntroductionHypoparathyroidism (HP) is a rare endocrine disease and there are little data available on the risk of fragility fractures in these patients. PTH deficiency results in a positive bone balance with higher bone mass in all skeletal sites. However, whether these structural and dynamic skeletal changes have a negative impact on the fracture risk, it is not known.MethodsAiming to investigate the risk of insufficiency vertebral fractures in HP, defined using morphometric criteria, a consecutive sampling of 44 women with chronic postsurgical HP was compared to a control group of 44 adult healthy women, matched by age with patients. Vertebral fractures were analyzed by the semiquantitative Genant’s method followed by quantitative vertebral morphometry.ResultsMorphometric vertebral fractures were identified in 5/44 (11.4%) patients and in 3/44 (6.8%) controls (p=0.731). Most fractures were classified as Genant II and III grades in HP patients, whereas most were Genant I in controls. A logistic regression multivariate analysis was conducted in which age, BMI and parathyroid status were the independent variables, and morphometric vertebral fracture was the dependent variable, but none of these factors was a significant predictor of fracture in this population (OR 1.01, 95% CI 0.96-1.07, p=0.634 for age; OR 2.24, 95%CI 0.47-10.50, p=0.306 for the presence/absence of HP and OR 0.92, 95% CI 0.76-1.10, p=0.369 for BMI).ConclusionThe results of this study cannot ensure a higher risk of fragility vertebral fractures in postsurgical HP patients. Instead, we only observed higher Genant grade classification of the deformed vertebrae in our sample. |
| first_indexed | 2024-04-11T05:28:28Z |
| format | Article |
| id | doaj.art-a912563670cb4b0aa5ab7a5d720945cd |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-04-11T05:28:28Z |
| publishDate | 2022-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-a912563670cb4b0aa5ab7a5d720945cd2022-12-23T04:50:50ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922022-12-011310.3389/fendo.2022.948435948435Morphometric vertebral fracture risk in women with postsurgical hypoparathyroidismCatarina Brasil d’Alva0André Rodrigues Façanha Barreto1Marcello H. Nogueira-Barbosa2Caio César Cavalcante Arruda3Áurea Maíla Albuquerque4Débora Mota Cordeiro Praciano5Rodrigo Ponte Viana6Daniel Duarte Gadelha7Antônio Brazil Viana Jr8Ilana Marques Moreira9Francisco José Rodrigues de Moura Filho10Ana Flávia Torquato de Araújo Junqueira11Renan Magalhães Montenegro Jr12Núcleo de Atendimento Multidisciplinar às Doenças Osteometabólicas, Depto. de Medicina Clínica da Universidade Federal do Ceara, Fortaleza, BrazilServiço de Radiologia, Hospital Universitário Walter Cantídio, Universidade Federal do Ceara, Fortaleza, BrazilDepartment of Radiology, Ribeirao Preto Medical School, University of São Paulo, Ribeirao Preto, BrazilServiço de Radiologia, Hospital Universitário Walter Cantídio, Universidade Federal do Ceara, Fortaleza, BrazilNúcleo de Atendimento Multidisciplinar às Doenças Osteometabólicas, Depto. de Medicina Clínica da Universidade Federal do Ceara, Fortaleza, BrazilNúcleo de Atendimento Multidisciplinar às Doenças Osteometabólicas, Depto. de Medicina Clínica da Universidade Federal do Ceara, Fortaleza, BrazilNúcleo de Atendimento Multidisciplinar às Doenças Osteometabólicas, Depto. de Medicina Clínica da Universidade Federal do Ceara, Fortaleza, BrazilUnidade de Pesquisa Clínica, Hospital Universitário Walter Cantídio, Universidade Federal do Ceara, Fortaleza, BrazilUnidade de Pesquisa Clínica, Hospital Universitário Walter Cantídio, Universidade Federal do Ceara, Fortaleza, BrazilNúcleo de Atendimento Multidisciplinar às Doenças Osteometabólicas, Depto. de Medicina Clínica da Universidade Federal do Ceara, Fortaleza, BrazilServiço de Radiologia, Hospital Universitário Walter Cantídio, Universidade Federal do Ceara, Fortaleza, BrazilNúcleo de Atendimento Multidisciplinar às Doenças Osteometabólicas, Depto. de Medicina Clínica da Universidade Federal do Ceara, Fortaleza, BrazilUnidade de Pesquisa Clínica, Hospital Universitário Walter Cantídio, Universidade Federal do Ceara, Fortaleza, BrazilIntroductionHypoparathyroidism (HP) is a rare endocrine disease and there are little data available on the risk of fragility fractures in these patients. PTH deficiency results in a positive bone balance with higher bone mass in all skeletal sites. However, whether these structural and dynamic skeletal changes have a negative impact on the fracture risk, it is not known.MethodsAiming to investigate the risk of insufficiency vertebral fractures in HP, defined using morphometric criteria, a consecutive sampling of 44 women with chronic postsurgical HP was compared to a control group of 44 adult healthy women, matched by age with patients. Vertebral fractures were analyzed by the semiquantitative Genant’s method followed by quantitative vertebral morphometry.ResultsMorphometric vertebral fractures were identified in 5/44 (11.4%) patients and in 3/44 (6.8%) controls (p=0.731). Most fractures were classified as Genant II and III grades in HP patients, whereas most were Genant I in controls. A logistic regression multivariate analysis was conducted in which age, BMI and parathyroid status were the independent variables, and morphometric vertebral fracture was the dependent variable, but none of these factors was a significant predictor of fracture in this population (OR 1.01, 95% CI 0.96-1.07, p=0.634 for age; OR 2.24, 95%CI 0.47-10.50, p=0.306 for the presence/absence of HP and OR 0.92, 95% CI 0.76-1.10, p=0.369 for BMI).ConclusionThe results of this study cannot ensure a higher risk of fragility vertebral fractures in postsurgical HP patients. Instead, we only observed higher Genant grade classification of the deformed vertebrae in our sample.https://www.frontiersin.org/articles/10.3389/fendo.2022.948435/fullpostsurgical hypoparathyroidismparathyroid-related disordersvertebral fracturemorphometric fractureradiography |
| spellingShingle | Catarina Brasil d’Alva André Rodrigues Façanha Barreto Marcello H. Nogueira-Barbosa Caio César Cavalcante Arruda Áurea Maíla Albuquerque Débora Mota Cordeiro Praciano Rodrigo Ponte Viana Daniel Duarte Gadelha Antônio Brazil Viana Jr Ilana Marques Moreira Francisco José Rodrigues de Moura Filho Ana Flávia Torquato de Araújo Junqueira Renan Magalhães Montenegro Jr Morphometric vertebral fracture risk in women with postsurgical hypoparathyroidism Frontiers in Endocrinology postsurgical hypoparathyroidism parathyroid-related disorders vertebral fracture morphometric fracture radiography |
| title | Morphometric vertebral fracture risk in women with postsurgical hypoparathyroidism |
| title_full | Morphometric vertebral fracture risk in women with postsurgical hypoparathyroidism |
| title_fullStr | Morphometric vertebral fracture risk in women with postsurgical hypoparathyroidism |
| title_full_unstemmed | Morphometric vertebral fracture risk in women with postsurgical hypoparathyroidism |
| title_short | Morphometric vertebral fracture risk in women with postsurgical hypoparathyroidism |
| title_sort | morphometric vertebral fracture risk in women with postsurgical hypoparathyroidism |
| topic | postsurgical hypoparathyroidism parathyroid-related disorders vertebral fracture morphometric fracture radiography |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2022.948435/full |
| work_keys_str_mv | AT catarinabrasildalva morphometricvertebralfractureriskinwomenwithpostsurgicalhypoparathyroidism AT andrerodriguesfacanhabarreto morphometricvertebralfractureriskinwomenwithpostsurgicalhypoparathyroidism AT marcellohnogueirabarbosa morphometricvertebralfractureriskinwomenwithpostsurgicalhypoparathyroidism AT caiocesarcavalcantearruda morphometricvertebralfractureriskinwomenwithpostsurgicalhypoparathyroidism AT aureamailaalbuquerque morphometricvertebralfractureriskinwomenwithpostsurgicalhypoparathyroidism AT deboramotacordeiropraciano morphometricvertebralfractureriskinwomenwithpostsurgicalhypoparathyroidism AT rodrigoponteviana morphometricvertebralfractureriskinwomenwithpostsurgicalhypoparathyroidism AT danielduartegadelha morphometricvertebralfractureriskinwomenwithpostsurgicalhypoparathyroidism AT antoniobrazilvianajr morphometricvertebralfractureriskinwomenwithpostsurgicalhypoparathyroidism AT ilanamarquesmoreira morphometricvertebralfractureriskinwomenwithpostsurgicalhypoparathyroidism AT franciscojoserodriguesdemourafilho morphometricvertebralfractureriskinwomenwithpostsurgicalhypoparathyroidism AT anaflaviatorquatodearaujojunqueira morphometricvertebralfractureriskinwomenwithpostsurgicalhypoparathyroidism AT renanmagalhaesmontenegrojr morphometricvertebralfractureriskinwomenwithpostsurgicalhypoparathyroidism |