The gastrointestinal behavior of saponins and its significance for their bioavailability and bioactivities
Saponins are bioactive compounds of increasing interest. The events that take place during digestion are highly related to their bioactivities, because saponins are poorly absorbed and have a long residence time in the intestinal tract. The poor bioavailability of saponins is explained by a sum of f...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2018-01-01
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| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464617307041 |
| _version_ | 1818957534136893440 |
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| author | Joaquín Navarro del Hierro Teresa Herrera Tiziana Fornari Guillermo Reglero Diana Martin |
| author_facet | Joaquín Navarro del Hierro Teresa Herrera Tiziana Fornari Guillermo Reglero Diana Martin |
| author_sort | Joaquín Navarro del Hierro |
| collection | DOAJ |
| description | Saponins are bioactive compounds of increasing interest. The events that take place during digestion are highly related to their bioactivities, because saponins are poorly absorbed and have a long residence time in the intestinal tract. The poor bioavailability of saponins is explained by a sum of factors, but the more favorable properties of sapogenins result in higher bioavailability and bioactivity. The gastric and colonic transformations of saponins are relevant in the release of sapogenins. Saponins inhibit enzymes and cholesterol absorption, but specific chemical structures of saponins are relevant for an efficient activity. Finally, the recent research has pointed to saponins as “prebiotic-like” compounds. This review summarizes the current knowledge on the events that take place during digestion of saponins and sapogenins related to their bioactivities, with special emphasis on the factors that modulate their bioavailability, bioaccessibility, inhibition of digestive enzymes and cholesterol absorption, and the importance of the microbiota-saponins relationship. |
| first_indexed | 2024-12-20T11:11:22Z |
| format | Article |
| id | doaj.art-a9132a6f7be54653af716420d3435568 |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-12-20T11:11:22Z |
| publishDate | 2018-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-a9132a6f7be54653af716420d34355682022-12-21T19:42:44ZengElsevierJournal of Functional Foods1756-46462018-01-0140484497The gastrointestinal behavior of saponins and its significance for their bioavailability and bioactivitiesJoaquín Navarro del Hierro0Teresa Herrera1Tiziana Fornari2Guillermo Reglero3Diana Martin4Departamento de Producción y Caracterización de Nuevos Alimentos, Instituto de Investigación en Ciencias de la Alimentación (CIAL) (CSIC–UAM), 28049 Madrid, Spain; Sección Departamental de Ciencias de la Alimentación, Facultad de Ciencias, Universidad Autónoma de Madrid, 28049 Madrid, SpainDepartamento de Producción y Caracterización de Nuevos Alimentos, Instituto de Investigación en Ciencias de la Alimentación (CIAL) (CSIC–UAM), 28049 Madrid, Spain; Sección Departamental de Ciencias de la Alimentación, Facultad de Ciencias, Universidad Autónoma de Madrid, 28049 Madrid, SpainDepartamento de Producción y Caracterización de Nuevos Alimentos, Instituto de Investigación en Ciencias de la Alimentación (CIAL) (CSIC–UAM), 28049 Madrid, Spain; Sección Departamental de Ciencias de la Alimentación, Facultad de Ciencias, Universidad Autónoma de Madrid, 28049 Madrid, SpainDepartamento de Producción y Caracterización de Nuevos Alimentos, Instituto de Investigación en Ciencias de la Alimentación (CIAL) (CSIC–UAM), 28049 Madrid, Spain; Sección Departamental de Ciencias de la Alimentación, Facultad de Ciencias, Universidad Autónoma de Madrid, 28049 Madrid, Spain; Imdea-Food Institute, CEI UAM+CSIC, 28049 Madrid, SpainDepartamento de Producción y Caracterización de Nuevos Alimentos, Instituto de Investigación en Ciencias de la Alimentación (CIAL) (CSIC–UAM), 28049 Madrid, Spain; Sección Departamental de Ciencias de la Alimentación, Facultad de Ciencias, Universidad Autónoma de Madrid, 28049 Madrid, Spain; Corresponding author at: Instituto de Investigación en Ciencias de la Alimentación (CIAL), Campus de la Universidad Autónoma de Madrid, 28049 Madrid, Spain.Saponins are bioactive compounds of increasing interest. The events that take place during digestion are highly related to their bioactivities, because saponins are poorly absorbed and have a long residence time in the intestinal tract. The poor bioavailability of saponins is explained by a sum of factors, but the more favorable properties of sapogenins result in higher bioavailability and bioactivity. The gastric and colonic transformations of saponins are relevant in the release of sapogenins. Saponins inhibit enzymes and cholesterol absorption, but specific chemical structures of saponins are relevant for an efficient activity. Finally, the recent research has pointed to saponins as “prebiotic-like” compounds. This review summarizes the current knowledge on the events that take place during digestion of saponins and sapogenins related to their bioactivities, with special emphasis on the factors that modulate their bioavailability, bioaccessibility, inhibition of digestive enzymes and cholesterol absorption, and the importance of the microbiota-saponins relationship.http://www.sciencedirect.com/science/article/pii/S1756464617307041SaponinsSapogeninsBioavailabilityEnzyme inhibitionHypocholesterolemicMicrobiota |
| spellingShingle | Joaquín Navarro del Hierro Teresa Herrera Tiziana Fornari Guillermo Reglero Diana Martin The gastrointestinal behavior of saponins and its significance for their bioavailability and bioactivities Journal of Functional Foods Saponins Sapogenins Bioavailability Enzyme inhibition Hypocholesterolemic Microbiota |
| title | The gastrointestinal behavior of saponins and its significance for their bioavailability and bioactivities |
| title_full | The gastrointestinal behavior of saponins and its significance for their bioavailability and bioactivities |
| title_fullStr | The gastrointestinal behavior of saponins and its significance for their bioavailability and bioactivities |
| title_full_unstemmed | The gastrointestinal behavior of saponins and its significance for their bioavailability and bioactivities |
| title_short | The gastrointestinal behavior of saponins and its significance for their bioavailability and bioactivities |
| title_sort | gastrointestinal behavior of saponins and its significance for their bioavailability and bioactivities |
| topic | Saponins Sapogenins Bioavailability Enzyme inhibition Hypocholesterolemic Microbiota |
| url | http://www.sciencedirect.com/science/article/pii/S1756464617307041 |
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