Disseminated Mycobacterium bovis Infection after BCG Vaccination
The Calmette-Güerin vaccine (BCG) is administered to all the newborns in Iran in order to prevent tuberculosis. Complications of this vaccine are uncommon. We report disseminated BCG disease in 17 patients less than 10 years old. This is a retrospective study of total of 17 cases who were admitted...
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| Format: | Article |
| Language: | English |
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Tehran University of Medical Sciences
2006-09-01
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| Series: | Iranian Journal of Allergy, Asthma and Immunology |
| Subjects: | |
| Online Access: | https://ijaai.tums.ac.ir/index.php/ijaai/article/view/146 |
| _version_ | 1828938339868213248 |
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| author | Shahla Afshar Paiman Ahmad Siadati Setareh Mamishi Parviz Tabatabaie and Ghamartaj Khotaee |
| author_facet | Shahla Afshar Paiman Ahmad Siadati Setareh Mamishi Parviz Tabatabaie and Ghamartaj Khotaee |
| author_sort | Shahla Afshar Paiman |
| collection | DOAJ |
| description | The Calmette-Güerin vaccine (BCG) is administered to all the newborns in Iran in order to prevent tuberculosis. Complications of this vaccine are uncommon. We report disseminated BCG disease in 17 patients less than 10 years old.
This is a retrospective study of total of 17 cases who were admitted in Children Medical Center Hospital with systemic syndrome compatible with Mycobacterium disease with evidence of histopathologic demonstration of acid-fast bacilli during 1995-2004.
Fourteen cases occurred in children younger than 1 year old. Nine patients were female. Ten of the 17 total cases were associated with an immune deficiency including severe combined immunodeficiency, chronic granulomatous disease and cell mediated immune defect. Response to therapy was ineffective and 10 of them (58.8%) died.
Disseminated BCG disease is an uncommon but devastating complication of vaccination that should be considered in the appropriate clinical setting. Immune-compromised infants are at greatest risk and they respond poorly to standard therapies. |
| first_indexed | 2024-12-14T02:39:43Z |
| format | Article |
| id | doaj.art-a9135eb47a724e97a52139d36739c8ac |
| institution | Directory Open Access Journal |
| issn | 1735-1502 1735-5249 |
| language | English |
| last_indexed | 2024-12-14T02:39:43Z |
| publishDate | 2006-09-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Allergy, Asthma and Immunology |
| spelling | doaj.art-a9135eb47a724e97a52139d36739c8ac2022-12-21T23:20:02ZengTehran University of Medical SciencesIranian Journal of Allergy, Asthma and Immunology1735-15021735-52492006-09-0153146Disseminated Mycobacterium bovis Infection after BCG Vaccination Shahla Afshar Paiman0 Ahmad Siadati1 Setareh Mamishi2 Parviz Tabatabaie3 and Ghamartaj Khotaee4 The Calmette-Güerin vaccine (BCG) is administered to all the newborns in Iran in order to prevent tuberculosis. Complications of this vaccine are uncommon. We report disseminated BCG disease in 17 patients less than 10 years old. This is a retrospective study of total of 17 cases who were admitted in Children Medical Center Hospital with systemic syndrome compatible with Mycobacterium disease with evidence of histopathologic demonstration of acid-fast bacilli during 1995-2004. Fourteen cases occurred in children younger than 1 year old. Nine patients were female. Ten of the 17 total cases were associated with an immune deficiency including severe combined immunodeficiency, chronic granulomatous disease and cell mediated immune defect. Response to therapy was ineffective and 10 of them (58.8%) died. Disseminated BCG disease is an uncommon but devastating complication of vaccination that should be considered in the appropriate clinical setting. Immune-compromised infants are at greatest risk and they respond poorly to standard therapies.https://ijaai.tums.ac.ir/index.php/ijaai/article/view/146BCG |
| spellingShingle | Shahla Afshar Paiman Ahmad Siadati Setareh Mamishi Parviz Tabatabaie and Ghamartaj Khotaee Disseminated Mycobacterium bovis Infection after BCG Vaccination Iranian Journal of Allergy, Asthma and Immunology BCG |
| title | Disseminated Mycobacterium bovis Infection after BCG Vaccination |
| title_full | Disseminated Mycobacterium bovis Infection after BCG Vaccination |
| title_fullStr | Disseminated Mycobacterium bovis Infection after BCG Vaccination |
| title_full_unstemmed | Disseminated Mycobacterium bovis Infection after BCG Vaccination |
| title_short | Disseminated Mycobacterium bovis Infection after BCG Vaccination |
| title_sort | disseminated mycobacterium bovis infection after bcg vaccination |
| topic | BCG |
| url | https://ijaai.tums.ac.ir/index.php/ijaai/article/view/146 |
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