Dissecting transcriptomic signatures of neuronal differentiation and maturation using iPSCs
Here, authors present results of a hiPSC transcriptomics study on corticogenesis from multiple donors across four transitions in differentiation. They present a bulk data deconvolution method and show that co-culturing human NPCs with rodent astrocytes results in mutually synergistic maturation.
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2020-01-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-14266-z |
| _version_ | 1818977833730441216 |
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| author | Emily E. Burke Joshua G. Chenoweth Joo Heon Shin Leonardo Collado-Torres Suel-Kee Kim Nicola Micali Yanhong Wang Carlo Colantuoni Richard E. Straub Daniel J. Hoeppner Huei-Ying Chen Alana Sellers Kamel Shibbani Gregory R. Hamersky Marcelo Diaz Bustamante BaDoi N. Phan William S. Ulrich Cristian Valencia Amritha Jaishankar Amanda J. Price Anandita Rajpurohit Stephen A. Semick Roland W. Bürli James C. Barrow Daniel J. Hiler Stephanie C. Page Keri Martinowich Thomas M. Hyde Joel E. Kleinman Karen F. Berman Jose A. Apud Alan J. Cross Nicholas J. Brandon Daniel R. Weinberger Brady J. Maher Ronald D. G. McKay Andrew E. Jaffe |
| author_facet | Emily E. Burke Joshua G. Chenoweth Joo Heon Shin Leonardo Collado-Torres Suel-Kee Kim Nicola Micali Yanhong Wang Carlo Colantuoni Richard E. Straub Daniel J. Hoeppner Huei-Ying Chen Alana Sellers Kamel Shibbani Gregory R. Hamersky Marcelo Diaz Bustamante BaDoi N. Phan William S. Ulrich Cristian Valencia Amritha Jaishankar Amanda J. Price Anandita Rajpurohit Stephen A. Semick Roland W. Bürli James C. Barrow Daniel J. Hiler Stephanie C. Page Keri Martinowich Thomas M. Hyde Joel E. Kleinman Karen F. Berman Jose A. Apud Alan J. Cross Nicholas J. Brandon Daniel R. Weinberger Brady J. Maher Ronald D. G. McKay Andrew E. Jaffe |
| author_sort | Emily E. Burke |
| collection | DOAJ |
| description | Here, authors present results of a hiPSC transcriptomics study on corticogenesis from multiple donors across four transitions in differentiation. They present a bulk data deconvolution method and show that co-culturing human NPCs with rodent astrocytes results in mutually synergistic maturation. |
| first_indexed | 2024-12-20T16:34:02Z |
| format | Article |
| id | doaj.art-a91415f76f3b4ff6b00a1fb9ef500aaf |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-20T16:34:02Z |
| publishDate | 2020-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-a91415f76f3b4ff6b00a1fb9ef500aaf2022-12-21T19:33:12ZengNature PortfolioNature Communications2041-17232020-01-0111111410.1038/s41467-019-14266-zDissecting transcriptomic signatures of neuronal differentiation and maturation using iPSCsEmily E. Burke0Joshua G. Chenoweth1Joo Heon Shin2Leonardo Collado-Torres3Suel-Kee Kim4Nicola Micali5Yanhong Wang6Carlo Colantuoni7Richard E. Straub8Daniel J. Hoeppner9Huei-Ying Chen10Alana Sellers11Kamel Shibbani12Gregory R. Hamersky13Marcelo Diaz Bustamante14BaDoi N. Phan15William S. Ulrich16Cristian Valencia17Amritha Jaishankar18Amanda J. Price19Anandita Rajpurohit20Stephen A. Semick21Roland W. Bürli22James C. Barrow23Daniel J. Hiler24Stephanie C. Page25Keri Martinowich26Thomas M. Hyde27Joel E. Kleinman28Karen F. Berman29Jose A. Apud30Alan J. Cross31Nicholas J. Brandon32Daniel R. Weinberger33Brady J. Maher34Ronald D. G. McKay35Andrew E. Jaffe36Lieber Institute for Brain DevelopmentLieber Institute for Brain DevelopmentLieber Institute for Brain DevelopmentLieber Institute for Brain DevelopmentLieber Institute for Brain DevelopmentLieber Institute for Brain DevelopmentLieber Institute for Brain DevelopmentLieber Institute for Brain DevelopmentLieber Institute for Brain DevelopmentLieber Institute for Brain DevelopmentLieber Institute for Brain DevelopmentLieber Institute for Brain DevelopmentLieber Institute for Brain DevelopmentLieber Institute for Brain DevelopmentLieber Institute for Brain DevelopmentLieber Institute for Brain DevelopmentLieber Institute for Brain DevelopmentLieber Institute for Brain DevelopmentLieber Institute for Brain DevelopmentLieber Institute for Brain DevelopmentLieber Institute for Brain DevelopmentLieber Institute for Brain DevelopmentNeuroscience, IMED Biotech Unit, AstraZenecaLieber Institute for Brain DevelopmentLieber Institute for Brain DevelopmentLieber Institute for Brain DevelopmentLieber Institute for Brain DevelopmentLieber Institute for Brain DevelopmentLieber Institute for Brain DevelopmentClinical and Translational Neuroscience Branch, NIMH Intramural Research ProgramClinical and Translational Neuroscience Branch, NIMH Intramural Research ProgramNeuroscience, IMED Biotech Unit, AstraZenecaNeuroscience, IMED Biotech Unit, AstraZenecaLieber Institute for Brain DevelopmentLieber Institute for Brain DevelopmentLieber Institute for Brain DevelopmentLieber Institute for Brain DevelopmentHere, authors present results of a hiPSC transcriptomics study on corticogenesis from multiple donors across four transitions in differentiation. They present a bulk data deconvolution method and show that co-culturing human NPCs with rodent astrocytes results in mutually synergistic maturation.https://doi.org/10.1038/s41467-019-14266-z |
| spellingShingle | Emily E. Burke Joshua G. Chenoweth Joo Heon Shin Leonardo Collado-Torres Suel-Kee Kim Nicola Micali Yanhong Wang Carlo Colantuoni Richard E. Straub Daniel J. Hoeppner Huei-Ying Chen Alana Sellers Kamel Shibbani Gregory R. Hamersky Marcelo Diaz Bustamante BaDoi N. Phan William S. Ulrich Cristian Valencia Amritha Jaishankar Amanda J. Price Anandita Rajpurohit Stephen A. Semick Roland W. Bürli James C. Barrow Daniel J. Hiler Stephanie C. Page Keri Martinowich Thomas M. Hyde Joel E. Kleinman Karen F. Berman Jose A. Apud Alan J. Cross Nicholas J. Brandon Daniel R. Weinberger Brady J. Maher Ronald D. G. McKay Andrew E. Jaffe Dissecting transcriptomic signatures of neuronal differentiation and maturation using iPSCs Nature Communications |
| title | Dissecting transcriptomic signatures of neuronal differentiation and maturation using iPSCs |
| title_full | Dissecting transcriptomic signatures of neuronal differentiation and maturation using iPSCs |
| title_fullStr | Dissecting transcriptomic signatures of neuronal differentiation and maturation using iPSCs |
| title_full_unstemmed | Dissecting transcriptomic signatures of neuronal differentiation and maturation using iPSCs |
| title_short | Dissecting transcriptomic signatures of neuronal differentiation and maturation using iPSCs |
| title_sort | dissecting transcriptomic signatures of neuronal differentiation and maturation using ipscs |
| url | https://doi.org/10.1038/s41467-019-14266-z |
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