Multidrug-resistant Cutibacterium avidum isolated from patients with acne vulgaris and other infections
ABSTRACT: Objectives: Cutibacterium avidum, a human skin commensal bacterium, rarely causes infections. It has recently been shown that Cutibacterium acnes, another member of the genus, acts as an opportunistic pathogen in surgical site infections. However, the antimicrobial susceptibility and path...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-03-01
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| Series: | Journal of Global Antimicrobial Resistance |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213716522000029 |
| _version_ | 1828855086228439040 |
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| author | Juri Koizumi Keisuke Nakase Nobukazu Hayashi Yutaka Nasu Yuji Hirai Hidemasa Nakaminami |
| author_facet | Juri Koizumi Keisuke Nakase Nobukazu Hayashi Yutaka Nasu Yuji Hirai Hidemasa Nakaminami |
| author_sort | Juri Koizumi |
| collection | DOAJ |
| description | ABSTRACT: Objectives: Cutibacterium avidum, a human skin commensal bacterium, rarely causes infections. It has recently been shown that Cutibacterium acnes, another member of the genus, acts as an opportunistic pathogen in surgical site infections. However, the antimicrobial susceptibility and pathogenicity of C. avidum remain unknown. Methods: We investigated the epidemiological features and antimicrobial susceptibility of C. avidum isolated from patients with acne vulgaris and other infections. Results: Cutibacterium avidum strains were isolated from patients with acne vulgaris (29 strains) and other infections (12 strains). Clarithromycin and clindamycin resistance was observed in 65.9% (27/41) of strains. In addition, ciprofloxacin resistance was observed in 34.1% (14/41) of strains, of which 13 also exhibited resistance to macrolides and clindamycin. Notably, the macrolide–clindamycin resistance gene erm(X) was found on the chromosome of 92.6% (25/27) of clindamycin-resistant strains and may be prevalent owing to transmission among C. avidum strains. Ciprofloxacin-resistant strains developed amino acid substitutions in GyrA owing to the use of antimicrobial agents. Pulsed-field gel electrophoresis (PFGE) analysis revealed that only a few strains exhibited 100% similarity. Additionally, no clustering associated with antimicrobial resistance, biofilm-forming ability or type of infection was observed. Conclusion: Our study revealed that erm(X) may be frequently disseminated in C. avidum, and multidrug-resistant C. avidum strains may colonise the skin of patients with acne vulgaris and other infections. Therefore, the prevalence of multidrug-resistant C. avidum and the use of antimicrobial agents for the treatment of acne vulgaris and other infections associated with C. avidum should be monitored. |
| first_indexed | 2024-12-13T00:48:02Z |
| format | Article |
| id | doaj.art-a916f3126ba9487093f606a96eb9f9f2 |
| institution | Directory Open Access Journal |
| issn | 2213-7165 |
| language | English |
| last_indexed | 2024-12-13T00:48:02Z |
| publishDate | 2022-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Global Antimicrobial Resistance |
| spelling | doaj.art-a916f3126ba9487093f606a96eb9f9f22022-12-22T00:05:00ZengElsevierJournal of Global Antimicrobial Resistance2213-71652022-03-0128151157Multidrug-resistant Cutibacterium avidum isolated from patients with acne vulgaris and other infectionsJuri Koizumi0Keisuke Nakase1Nobukazu Hayashi2Yutaka Nasu3Yuji Hirai4Hidemasa Nakaminami5Department of Clinical Microbiology, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, JapanDepartment of Clinical Microbiology, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan; Corresponding author. Tel.: +81 426 76 5129; fax: +81 426 76 5647.Department of Dermatology, Toranomon Hospital, 2-2-2 Toranomon, Minato-ku, Tokyo 105-8470, JapanDepartment of Infectious Diseases, Tokyo Medical University Hachioji Medical Center, 1163 Tatemachi, Hachioji, Tokyo 193-0944, JapanDepartment of Infectious Diseases, Tokyo Medical University Hachioji Medical Center, 1163 Tatemachi, Hachioji, Tokyo 193-0944, JapanDepartment of Clinical Microbiology, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, JapanABSTRACT: Objectives: Cutibacterium avidum, a human skin commensal bacterium, rarely causes infections. It has recently been shown that Cutibacterium acnes, another member of the genus, acts as an opportunistic pathogen in surgical site infections. However, the antimicrobial susceptibility and pathogenicity of C. avidum remain unknown. Methods: We investigated the epidemiological features and antimicrobial susceptibility of C. avidum isolated from patients with acne vulgaris and other infections. Results: Cutibacterium avidum strains were isolated from patients with acne vulgaris (29 strains) and other infections (12 strains). Clarithromycin and clindamycin resistance was observed in 65.9% (27/41) of strains. In addition, ciprofloxacin resistance was observed in 34.1% (14/41) of strains, of which 13 also exhibited resistance to macrolides and clindamycin. Notably, the macrolide–clindamycin resistance gene erm(X) was found on the chromosome of 92.6% (25/27) of clindamycin-resistant strains and may be prevalent owing to transmission among C. avidum strains. Ciprofloxacin-resistant strains developed amino acid substitutions in GyrA owing to the use of antimicrobial agents. Pulsed-field gel electrophoresis (PFGE) analysis revealed that only a few strains exhibited 100% similarity. Additionally, no clustering associated with antimicrobial resistance, biofilm-forming ability or type of infection was observed. Conclusion: Our study revealed that erm(X) may be frequently disseminated in C. avidum, and multidrug-resistant C. avidum strains may colonise the skin of patients with acne vulgaris and other infections. Therefore, the prevalence of multidrug-resistant C. avidum and the use of antimicrobial agents for the treatment of acne vulgaris and other infections associated with C. avidum should be monitored.http://www.sciencedirect.com/science/article/pii/S2213716522000029Cutibacterium avidumMultidrug resistanceerm(X)Surgical site infection |
| spellingShingle | Juri Koizumi Keisuke Nakase Nobukazu Hayashi Yutaka Nasu Yuji Hirai Hidemasa Nakaminami Multidrug-resistant Cutibacterium avidum isolated from patients with acne vulgaris and other infections Journal of Global Antimicrobial Resistance Cutibacterium avidum Multidrug resistance erm(X) Surgical site infection |
| title | Multidrug-resistant Cutibacterium avidum isolated from patients with acne vulgaris and other infections |
| title_full | Multidrug-resistant Cutibacterium avidum isolated from patients with acne vulgaris and other infections |
| title_fullStr | Multidrug-resistant Cutibacterium avidum isolated from patients with acne vulgaris and other infections |
| title_full_unstemmed | Multidrug-resistant Cutibacterium avidum isolated from patients with acne vulgaris and other infections |
| title_short | Multidrug-resistant Cutibacterium avidum isolated from patients with acne vulgaris and other infections |
| title_sort | multidrug resistant cutibacterium avidum isolated from patients with acne vulgaris and other infections |
| topic | Cutibacterium avidum Multidrug resistance erm(X) Surgical site infection |
| url | http://www.sciencedirect.com/science/article/pii/S2213716522000029 |
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