Degeneration of dopaminergic neurons due to metabolic alterations and Parkinson’s disease
The rates of metabolic diseases, such as type 2 diabetes mellitus (T2DM), obesity, and cardiovascular disease, markedly increase with age. In recent years, studies have reported an association between metabolic changes and various pathophysiological mechanisms in the central nervous system (CNS) in...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2016-03-01
|
| Series: | Frontiers in Aging Neuroscience |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnagi.2016.00065/full |
| _version_ | 1818364444566093824 |
|---|---|
| author | Juhyun eSong JONGPIL eKIM |
| author_facet | Juhyun eSong JONGPIL eKIM |
| author_sort | Juhyun eSong |
| collection | DOAJ |
| description | The rates of metabolic diseases, such as type 2 diabetes mellitus (T2DM), obesity, and cardiovascular disease, markedly increase with age. In recent years, studies have reported an association between metabolic changes and various pathophysiological mechanisms in the central nervous system (CNS) in patients with metabolic diseases. Oxidative stress and hyperglycemia in metabolic diseases lead to adverse neurophysiological phenomena, including neuronal loss, synaptic dysfunction, and improper insulin signaling, resulting in Parkinson’s disease (PD). In addition, several lines of evidence suggest that alterations of CNS environments by metabolic changes influence the dopamine neuronal loss, eventually affecting the pathogenesis of PD. Thus, we reviewed recent findings relating to degeneration of dopaminergic neurons during metabolic diseases. We highlight the fact that using a metabolic approach to manipulate degeneration of dopaminergic neurons can serve as a therapeutic strategy to attenuate pathology of PD. |
| first_indexed | 2024-12-13T22:04:28Z |
| format | Article |
| id | doaj.art-a919cd0a7d8f4084994ecd4658648d4c |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-12-13T22:04:28Z |
| publishDate | 2016-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-a919cd0a7d8f4084994ecd4658648d4c2022-12-21T23:29:54ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652016-03-01810.3389/fnagi.2016.00065190650Degeneration of dopaminergic neurons due to metabolic alterations and Parkinson’s diseaseJuhyun eSong0JONGPIL eKIM1Dongguk UniversityDongguk UniversityThe rates of metabolic diseases, such as type 2 diabetes mellitus (T2DM), obesity, and cardiovascular disease, markedly increase with age. In recent years, studies have reported an association between metabolic changes and various pathophysiological mechanisms in the central nervous system (CNS) in patients with metabolic diseases. Oxidative stress and hyperglycemia in metabolic diseases lead to adverse neurophysiological phenomena, including neuronal loss, synaptic dysfunction, and improper insulin signaling, resulting in Parkinson’s disease (PD). In addition, several lines of evidence suggest that alterations of CNS environments by metabolic changes influence the dopamine neuronal loss, eventually affecting the pathogenesis of PD. Thus, we reviewed recent findings relating to degeneration of dopaminergic neurons during metabolic diseases. We highlight the fact that using a metabolic approach to manipulate degeneration of dopaminergic neurons can serve as a therapeutic strategy to attenuate pathology of PD.http://journal.frontiersin.org/Journal/10.3389/fnagi.2016.00065/fullAgingDopaminergic NeuronsMetabolic DiseasesNeurodegenerative DiseasesParkinson’s disease (PD) |
| spellingShingle | Juhyun eSong JONGPIL eKIM Degeneration of dopaminergic neurons due to metabolic alterations and Parkinson’s disease Frontiers in Aging Neuroscience Aging Dopaminergic Neurons Metabolic Diseases Neurodegenerative Diseases Parkinson’s disease (PD) |
| title | Degeneration of dopaminergic neurons due to metabolic alterations and Parkinson’s disease |
| title_full | Degeneration of dopaminergic neurons due to metabolic alterations and Parkinson’s disease |
| title_fullStr | Degeneration of dopaminergic neurons due to metabolic alterations and Parkinson’s disease |
| title_full_unstemmed | Degeneration of dopaminergic neurons due to metabolic alterations and Parkinson’s disease |
| title_short | Degeneration of dopaminergic neurons due to metabolic alterations and Parkinson’s disease |
| title_sort | degeneration of dopaminergic neurons due to metabolic alterations and parkinson s disease |
| topic | Aging Dopaminergic Neurons Metabolic Diseases Neurodegenerative Diseases Parkinson’s disease (PD) |
| url | http://journal.frontiersin.org/Journal/10.3389/fnagi.2016.00065/full |
| work_keys_str_mv | AT juhyunesong degenerationofdopaminergicneuronsduetometabolicalterationsandparkinsonsdisease AT jongpilekim degenerationofdopaminergicneuronsduetometabolicalterationsandparkinsonsdisease |