Follicle Fitness: Key Factors for Ovarian Health and Better Contraceptive Strategies
The ovarian follicle is an important endocrine organ that controls the female reproductive cycle through hypothalamic-pituitary-ovarian hormonal communication, an intricate network that governs reproductive fitness. Using genomics and molecular techniques our research is uncovering the processes by...
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
World Scientific Publishing
2023-12-01
|
| Series: | Fertility & Reproduction |
| Online Access: | https://www.worldscientific.com/doi/10.1142/S2661318223740663 |
| _version_ | 1797237088185221120 |
|---|---|
| author | Darryl Russell |
| author_facet | Darryl Russell |
| author_sort | Darryl Russell |
| collection | DOAJ |
| description | The ovarian follicle is an important endocrine organ that controls the female reproductive cycle through hypothalamic-pituitary-ovarian hormonal communication, an intricate network that governs reproductive fitness. Using genomics and molecular techniques our research is uncovering the processes by which ovarian folliculogenesis and oocyte development is regulated by the interplay of endocrine and paracrine signals that mediate coordinated growth and remodelling of the follicle, oocyte maturation and ultimately ovulation of a mature oocyte. We are investigating the consequences of dysregulation of hormones or their signalling networks that can lead to reproductive disorders such as polycystic ovary syndrome (PCOS) or impaired fertility through failure of ovulation or oocyte developmental competence. Ovulation is the pivotal event where the mature oocyte, surrounded by the expanded cumulus complex, is released from the follicle into the fallopian tube. This event is a critical target for understanding causes of infertility, developing therapies to reverse these causes, and also developing new contraceptives that do not disrupt endocrine function. In particular we are interrogating the molecular genomics of ovarian responses to the LH-surge and the steroids progesterone, androgen, estrogen, and others. Deciphering this endocrine network enriches our understanding of female reproductive biology and opens new avenues for interventions and fertility treatments. |
| first_indexed | 2024-04-24T17:14:11Z |
| format | Article |
| id | doaj.art-a919d3c490c8495c8512865dd0ca01d2 |
| institution | Directory Open Access Journal |
| issn | 2661-3182 2661-3174 |
| language | English |
| last_indexed | 2024-04-24T17:14:11Z |
| publishDate | 2023-12-01 |
| publisher | World Scientific Publishing |
| record_format | Article |
| series | Fertility & Reproduction |
| spelling | doaj.art-a919d3c490c8495c8512865dd0ca01d22024-03-28T07:54:18ZengWorld Scientific PublishingFertility & Reproduction2661-31822661-31742023-12-01050425225210.1142/S2661318223740663Follicle Fitness: Key Factors for Ovarian Health and Better Contraceptive StrategiesDarryl Russell0Research Fellow, University of Adelaide, AustraliaThe ovarian follicle is an important endocrine organ that controls the female reproductive cycle through hypothalamic-pituitary-ovarian hormonal communication, an intricate network that governs reproductive fitness. Using genomics and molecular techniques our research is uncovering the processes by which ovarian folliculogenesis and oocyte development is regulated by the interplay of endocrine and paracrine signals that mediate coordinated growth and remodelling of the follicle, oocyte maturation and ultimately ovulation of a mature oocyte. We are investigating the consequences of dysregulation of hormones or their signalling networks that can lead to reproductive disorders such as polycystic ovary syndrome (PCOS) or impaired fertility through failure of ovulation or oocyte developmental competence. Ovulation is the pivotal event where the mature oocyte, surrounded by the expanded cumulus complex, is released from the follicle into the fallopian tube. This event is a critical target for understanding causes of infertility, developing therapies to reverse these causes, and also developing new contraceptives that do not disrupt endocrine function. In particular we are interrogating the molecular genomics of ovarian responses to the LH-surge and the steroids progesterone, androgen, estrogen, and others. Deciphering this endocrine network enriches our understanding of female reproductive biology and opens new avenues for interventions and fertility treatments.https://www.worldscientific.com/doi/10.1142/S2661318223740663 |
| spellingShingle | Darryl Russell Follicle Fitness: Key Factors for Ovarian Health and Better Contraceptive Strategies Fertility & Reproduction |
| title | Follicle Fitness: Key Factors for Ovarian Health and Better Contraceptive Strategies |
| title_full | Follicle Fitness: Key Factors for Ovarian Health and Better Contraceptive Strategies |
| title_fullStr | Follicle Fitness: Key Factors for Ovarian Health and Better Contraceptive Strategies |
| title_full_unstemmed | Follicle Fitness: Key Factors for Ovarian Health and Better Contraceptive Strategies |
| title_short | Follicle Fitness: Key Factors for Ovarian Health and Better Contraceptive Strategies |
| title_sort | follicle fitness key factors for ovarian health and better contraceptive strategies |
| url | https://www.worldscientific.com/doi/10.1142/S2661318223740663 |
| work_keys_str_mv | AT darrylrussell folliclefitnesskeyfactorsforovarianhealthandbettercontraceptivestrategies |