Can Pre-Treatment Inflammatory Parameters Predict the Probability of Sphincter-Preserving Surgery in Patients with Locally Advanced Low-Lying Rectal Cancer?
There is evidence suggesting that pre-treatment clinical parameters can predict the probability of sphincter-preserving surgery in rectal cancer; however, to date, data on the predictive role of inflammatory parameters on the sphincter-preservation rate are not available. The aim of the present coho...
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MDPI AG
2021-05-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/11/6/946 |
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| author | Richard Partl Katarzyna Lukasiak Bettina Stranz Eva Hassler Marton Magyar Heidi Stranzl-Lawatsch Tanja Langsenlehner |
| author_facet | Richard Partl Katarzyna Lukasiak Bettina Stranz Eva Hassler Marton Magyar Heidi Stranzl-Lawatsch Tanja Langsenlehner |
| author_sort | Richard Partl |
| collection | DOAJ |
| description | There is evidence suggesting that pre-treatment clinical parameters can predict the probability of sphincter-preserving surgery in rectal cancer; however, to date, data on the predictive role of inflammatory parameters on the sphincter-preservation rate are not available. The aim of the present cohort study was to investigate the association between inflammation-based parameters and the sphincter-preserving surgery rate in patients with low-lying locally advanced rectal cancer (LARC). A total of 848 patients with LARC undergoing radiotherapy from 2004 to 2019 were retrospectively reviewed in order to identify patients with rectal cancer localized ≤6 cm from the anal verge, treated with neo-adjuvant radiochemotherapy (nRCT) and subsequent surgery. Univariable and multivariable analyses were used to investigate the role of pre-treatment inflammatory parameters, including the C-reactive protein (CRP), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR) for the prediction of sphincter preservation. A total of 363 patients met the inclusion criteria; among them, 210 patients (57.9%) underwent sphincter-preserving surgery, and in 153 patients (42.1%), an abdominoperineal rectum resection was performed. Univariable analysis showed a significant association of the pre-treatment CRP value (OR = 2.548, 95% CI: 1.584–4.097, <i>p</i> < 0.001) with sphincter preservation, whereas the pre-treatment NLR (OR = 1.098, 95% CI: 0.976–1.235, <i>p</i> = 0.120) and PLR (OR = 1.002, 95% CI: 1.000–1.005, <i>p</i> = 0.062) were not significantly associated with the type of surgery. In multivariable analysis, the pre-treatment CRP value (OR = 2.544; 95% CI: 1.314–4.926; <i>p</i> = 0.006) was identified as an independent predictive factor for sphincter-preserving surgery. The findings of the present study suggest that the pre-treatment CRP value represents an independent parameter predicting the probability of sphincter-preserving surgery in patients with low-lying LARC. |
| first_indexed | 2024-03-10T11:03:42Z |
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| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
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| spelling | doaj.art-a91bb7ed86284b2da8219032d1bd6ff52023-11-21T21:20:36ZengMDPI AGDiagnostics2075-44182021-05-0111694610.3390/diagnostics11060946Can Pre-Treatment Inflammatory Parameters Predict the Probability of Sphincter-Preserving Surgery in Patients with Locally Advanced Low-Lying Rectal Cancer?Richard Partl0Katarzyna Lukasiak1Bettina Stranz2Eva Hassler3Marton Magyar4Heidi Stranzl-Lawatsch5Tanja Langsenlehner6Department of Therapeutic Radiology and Oncology, Comprehensive Cancer Center, Medical University of Graz, 8036 Graz, AustriaDepartment of Therapeutic Radiology and Oncology, Comprehensive Cancer Center, Medical University of Graz, 8036 Graz, AustriaDepartment of Therapeutic Radiology and Oncology, Comprehensive Cancer Center, Medical University of Graz, 8036 Graz, AustriaDivision of Neuroradiology, Vascular and Interventional Radiology, Comprehensive Cancer Center Graz (CCC), Medical University of Graz, Auenbruggerplatz 9, 8036 Graz, AustriaDivision of Neuroradiology, Vascular and Interventional Radiology, Comprehensive Cancer Center Graz (CCC), Medical University of Graz, Auenbruggerplatz 9, 8036 Graz, AustriaDepartment of Therapeutic Radiology and Oncology, Comprehensive Cancer Center, Medical University of Graz, 8036 Graz, AustriaDepartment of Therapeutic Radiology and Oncology, Comprehensive Cancer Center, Medical University of Graz, 8036 Graz, AustriaThere is evidence suggesting that pre-treatment clinical parameters can predict the probability of sphincter-preserving surgery in rectal cancer; however, to date, data on the predictive role of inflammatory parameters on the sphincter-preservation rate are not available. The aim of the present cohort study was to investigate the association between inflammation-based parameters and the sphincter-preserving surgery rate in patients with low-lying locally advanced rectal cancer (LARC). A total of 848 patients with LARC undergoing radiotherapy from 2004 to 2019 were retrospectively reviewed in order to identify patients with rectal cancer localized ≤6 cm from the anal verge, treated with neo-adjuvant radiochemotherapy (nRCT) and subsequent surgery. Univariable and multivariable analyses were used to investigate the role of pre-treatment inflammatory parameters, including the C-reactive protein (CRP), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR) for the prediction of sphincter preservation. A total of 363 patients met the inclusion criteria; among them, 210 patients (57.9%) underwent sphincter-preserving surgery, and in 153 patients (42.1%), an abdominoperineal rectum resection was performed. Univariable analysis showed a significant association of the pre-treatment CRP value (OR = 2.548, 95% CI: 1.584–4.097, <i>p</i> < 0.001) with sphincter preservation, whereas the pre-treatment NLR (OR = 1.098, 95% CI: 0.976–1.235, <i>p</i> = 0.120) and PLR (OR = 1.002, 95% CI: 1.000–1.005, <i>p</i> = 0.062) were not significantly associated with the type of surgery. In multivariable analysis, the pre-treatment CRP value (OR = 2.544; 95% CI: 1.314–4.926; <i>p</i> = 0.006) was identified as an independent predictive factor for sphincter-preserving surgery. The findings of the present study suggest that the pre-treatment CRP value represents an independent parameter predicting the probability of sphincter-preserving surgery in patients with low-lying LARC.https://www.mdpi.com/2075-4418/11/6/946low rectal cancerlocally advanced rectal cancerpredictive factorspre-treatment parametersinflammatory parameters sphincter-preserving surgery |
| spellingShingle | Richard Partl Katarzyna Lukasiak Bettina Stranz Eva Hassler Marton Magyar Heidi Stranzl-Lawatsch Tanja Langsenlehner Can Pre-Treatment Inflammatory Parameters Predict the Probability of Sphincter-Preserving Surgery in Patients with Locally Advanced Low-Lying Rectal Cancer? Diagnostics low rectal cancer locally advanced rectal cancer predictive factors pre-treatment parameters inflammatory parameters sphincter-preserving surgery |
| title | Can Pre-Treatment Inflammatory Parameters Predict the Probability of Sphincter-Preserving Surgery in Patients with Locally Advanced Low-Lying Rectal Cancer? |
| title_full | Can Pre-Treatment Inflammatory Parameters Predict the Probability of Sphincter-Preserving Surgery in Patients with Locally Advanced Low-Lying Rectal Cancer? |
| title_fullStr | Can Pre-Treatment Inflammatory Parameters Predict the Probability of Sphincter-Preserving Surgery in Patients with Locally Advanced Low-Lying Rectal Cancer? |
| title_full_unstemmed | Can Pre-Treatment Inflammatory Parameters Predict the Probability of Sphincter-Preserving Surgery in Patients with Locally Advanced Low-Lying Rectal Cancer? |
| title_short | Can Pre-Treatment Inflammatory Parameters Predict the Probability of Sphincter-Preserving Surgery in Patients with Locally Advanced Low-Lying Rectal Cancer? |
| title_sort | can pre treatment inflammatory parameters predict the probability of sphincter preserving surgery in patients with locally advanced low lying rectal cancer |
| topic | low rectal cancer locally advanced rectal cancer predictive factors pre-treatment parameters inflammatory parameters sphincter-preserving surgery |
| url | https://www.mdpi.com/2075-4418/11/6/946 |
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