Changing Perspectives from Oxidative Stress to Redox Signaling—Extracellular Redox Control in Translational Medicine
Extensive research has changed the understanding of oxidative stress that has been linked to every major disease. Today we distinguish oxidative eu- and distress, acknowledging that redox modifications are crucial for signal transduction in the form of specific thiol switches. Long underestimated, r...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-06-01
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| Series: | Antioxidants |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-3921/11/6/1181 |
| _version_ | 1797490484118028288 |
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| author | Paola Loreto Palacio José R. Godoy Orhan Aktas Eva-Maria Hanschmann |
| author_facet | Paola Loreto Palacio José R. Godoy Orhan Aktas Eva-Maria Hanschmann |
| author_sort | Paola Loreto Palacio |
| collection | DOAJ |
| description | Extensive research has changed the understanding of oxidative stress that has been linked to every major disease. Today we distinguish oxidative eu- and distress, acknowledging that redox modifications are crucial for signal transduction in the form of specific thiol switches. Long underestimated, reactive species and redox proteins of the Thioredoxin (Trx) family are indeed essential for physiological processes. Moreover, extracellular redox proteins, low molecular weight thiols and thiol switches affect signal transduction and cell–cell communication. Here, we highlight the impact of extracellular redox regulation for health, intermediate pathophenotypes and disease. Of note, recent advances allow the analysis of redox changes in body fluids without using invasive and expensive techniques. With this new knowledge in redox biochemistry, translational strategies can lead to innovative new preventive and diagnostic tools and treatments in life sciences and medicine. |
| first_indexed | 2024-03-10T00:33:39Z |
| format | Article |
| id | doaj.art-a91ecf8ba81a4b208aa52f2b7c96e1ef |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-10T00:33:39Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-a91ecf8ba81a4b208aa52f2b7c96e1ef2023-11-23T15:21:01ZengMDPI AGAntioxidants2076-39212022-06-01116118110.3390/antiox11061181Changing Perspectives from Oxidative Stress to Redox Signaling—Extracellular Redox Control in Translational MedicinePaola Loreto Palacio0José R. Godoy1Orhan Aktas2Eva-Maria Hanschmann3Department of Neurology, Medical Faculty, Heinrich Heine University, Moorenstraße 5, 40225 Düsseldorf, GermanyDepartment of Veterinary Biomedical Sciences, Long Island University College of Veterinary Medicine, 720 Northern Boulevard, Brookville, NY 11548, USADepartment of Neurology, Medical Faculty, Heinrich Heine University, Moorenstraße 5, 40225 Düsseldorf, GermanyDepartment of Neurology, Medical Faculty, Heinrich Heine University, Moorenstraße 5, 40225 Düsseldorf, GermanyExtensive research has changed the understanding of oxidative stress that has been linked to every major disease. Today we distinguish oxidative eu- and distress, acknowledging that redox modifications are crucial for signal transduction in the form of specific thiol switches. Long underestimated, reactive species and redox proteins of the Thioredoxin (Trx) family are indeed essential for physiological processes. Moreover, extracellular redox proteins, low molecular weight thiols and thiol switches affect signal transduction and cell–cell communication. Here, we highlight the impact of extracellular redox regulation for health, intermediate pathophenotypes and disease. Of note, recent advances allow the analysis of redox changes in body fluids without using invasive and expensive techniques. With this new knowledge in redox biochemistry, translational strategies can lead to innovative new preventive and diagnostic tools and treatments in life sciences and medicine.https://www.mdpi.com/2076-3921/11/6/1181oxidative stressextracellular redox regulationreactive oxygen speciesglutathionethioredoxin proteinstranslational medicine |
| spellingShingle | Paola Loreto Palacio José R. Godoy Orhan Aktas Eva-Maria Hanschmann Changing Perspectives from Oxidative Stress to Redox Signaling—Extracellular Redox Control in Translational Medicine Antioxidants oxidative stress extracellular redox regulation reactive oxygen species glutathione thioredoxin proteins translational medicine |
| title | Changing Perspectives from Oxidative Stress to Redox Signaling—Extracellular Redox Control in Translational Medicine |
| title_full | Changing Perspectives from Oxidative Stress to Redox Signaling—Extracellular Redox Control in Translational Medicine |
| title_fullStr | Changing Perspectives from Oxidative Stress to Redox Signaling—Extracellular Redox Control in Translational Medicine |
| title_full_unstemmed | Changing Perspectives from Oxidative Stress to Redox Signaling—Extracellular Redox Control in Translational Medicine |
| title_short | Changing Perspectives from Oxidative Stress to Redox Signaling—Extracellular Redox Control in Translational Medicine |
| title_sort | changing perspectives from oxidative stress to redox signaling extracellular redox control in translational medicine |
| topic | oxidative stress extracellular redox regulation reactive oxygen species glutathione thioredoxin proteins translational medicine |
| url | https://www.mdpi.com/2076-3921/11/6/1181 |
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