Hypoxic pulmonary endothelial cells release epidermal growth factor leading to vascular smooth muscle cell arginase‐2 expression and proliferation

Hypoxic pulmonary endothelial cells release epidermal growth factor leading to vascular smooth muscle cell arginase‐2 expression and proliferation

Abstract The hallmark of pulmonary hypertension (PH) is vascular remodeling. We have previously shown that human pulmonary microvascular endothelial cells (hPMVEC) respond to hypoxia with epidermal growth factor (EGF) mediated activation of the receptor tyrosine kinase, EGF receptor (EGFR), resultin...

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Bibliographic Details
Main Authors: Bernadette Chen, Yi Jin, Caitlyn M. Pool, Yusen Liu, Leif D. Nelin
Format: Article
Language:English
Published: Wiley 2022-06-01
Series:Physiological Reports
Subjects:
epidermal growth factor receptor
pulmonary hypertension
pulmonary vascular remodeling
Online Access:https://doi.org/10.14814/phy2.15342

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