Probiotics for the prevention of atopic dermatitis in infants from different geographic regions: a systematic review and Meta-analysis
Background Atopic dermatitis (AD) is a common skin disease during infancy, but the preventive effect of probiotics on AD remains unclear. Aim To evaluate the efficacy of probiotic supplementation for the prevention of AD in infants. Methods PubMed, Cochrane Library, and Embase databases were reviewe...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2022-10-01
|
| Series: | Journal of Dermatological Treatment |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/09546634.2022.2091101 |
| _version_ | 1797683489244446720 |
|---|---|
| author | Lifeng Chen Yongshan Ni Xingdong Wu Guixia Chen |
| author_facet | Lifeng Chen Yongshan Ni Xingdong Wu Guixia Chen |
| author_sort | Lifeng Chen |
| collection | DOAJ |
| description | Background Atopic dermatitis (AD) is a common skin disease during infancy, but the preventive effect of probiotics on AD remains unclear. Aim To evaluate the efficacy of probiotic supplementation for the prevention of AD in infants. Methods PubMed, Cochrane Library, and Embase databases were reviewed for relevant randomized controlled trials (RCTs). Two authors independently extracted the data. The primary endpoint was the risk of AD in infants. Risk ratio (RR) and 95% confidence interval (CI) were calculated. Results A total of 20 related articles including 22 studies were included. A significant reduction in AD risk was revealed for the probiotic group compared to the control group (RR 0.76; 95% CI 0.67–0.87). Subgroup analyses by participant receiving intervention revealed that not only probiotics given to mother (RR 0.70; 95% CI 0.57-0.85) or given to mother and infant (RR 0.76; 95% CI 0.61-0.95) were effective in preventing AD in infants, and probiotics given to infants alone (RR 0.76; 95% CI 0.60-0.96) still effectively decreased the risk of AD. Conclusion Probiotic supplementation reduced the risk of developing AD in infants. Furthermore, probiotic supplementation given to mother or to mother and infant could effectively prevent AD in infants. |
| first_indexed | 2024-03-12T00:15:10Z |
| format | Article |
| id | doaj.art-a9219aeae41d4c2089b49be2df119ada |
| institution | Directory Open Access Journal |
| issn | 0954-6634 1471-1753 |
| language | English |
| last_indexed | 2024-03-12T00:15:10Z |
| publishDate | 2022-10-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Journal of Dermatological Treatment |
| spelling | doaj.art-a9219aeae41d4c2089b49be2df119ada2023-09-15T14:28:52ZengTaylor & Francis GroupJournal of Dermatological Treatment0954-66341471-17532022-10-013372931293910.1080/09546634.2022.20911012091101Probiotics for the prevention of atopic dermatitis in infants from different geographic regions: a systematic review and Meta-analysisLifeng Chen0Yongshan Ni1Xingdong Wu2Guixia Chen3Pritzker School of Molecular Engineering, University of ChicagoDepartment of Dermatology, Fujian Medical University Union HospitalXiamen Children’s Hospital, Children's Hospital of Fudan University Xiamen BranchWomen and Children's Hospital, School of Medicine, Xiamen UniversityBackground Atopic dermatitis (AD) is a common skin disease during infancy, but the preventive effect of probiotics on AD remains unclear. Aim To evaluate the efficacy of probiotic supplementation for the prevention of AD in infants. Methods PubMed, Cochrane Library, and Embase databases were reviewed for relevant randomized controlled trials (RCTs). Two authors independently extracted the data. The primary endpoint was the risk of AD in infants. Risk ratio (RR) and 95% confidence interval (CI) were calculated. Results A total of 20 related articles including 22 studies were included. A significant reduction in AD risk was revealed for the probiotic group compared to the control group (RR 0.76; 95% CI 0.67–0.87). Subgroup analyses by participant receiving intervention revealed that not only probiotics given to mother (RR 0.70; 95% CI 0.57-0.85) or given to mother and infant (RR 0.76; 95% CI 0.61-0.95) were effective in preventing AD in infants, and probiotics given to infants alone (RR 0.76; 95% CI 0.60-0.96) still effectively decreased the risk of AD. Conclusion Probiotic supplementation reduced the risk of developing AD in infants. Furthermore, probiotic supplementation given to mother or to mother and infant could effectively prevent AD in infants.http://dx.doi.org/10.1080/09546634.2022.2091101probioticsatopic dermatitisrandomized controlled trialsmeta-analysis |
| spellingShingle | Lifeng Chen Yongshan Ni Xingdong Wu Guixia Chen Probiotics for the prevention of atopic dermatitis in infants from different geographic regions: a systematic review and Meta-analysis Journal of Dermatological Treatment probiotics atopic dermatitis randomized controlled trials meta-analysis |
| title | Probiotics for the prevention of atopic dermatitis in infants from different geographic regions: a systematic review and Meta-analysis |
| title_full | Probiotics for the prevention of atopic dermatitis in infants from different geographic regions: a systematic review and Meta-analysis |
| title_fullStr | Probiotics for the prevention of atopic dermatitis in infants from different geographic regions: a systematic review and Meta-analysis |
| title_full_unstemmed | Probiotics for the prevention of atopic dermatitis in infants from different geographic regions: a systematic review and Meta-analysis |
| title_short | Probiotics for the prevention of atopic dermatitis in infants from different geographic regions: a systematic review and Meta-analysis |
| title_sort | probiotics for the prevention of atopic dermatitis in infants from different geographic regions a systematic review and meta analysis |
| topic | probiotics atopic dermatitis randomized controlled trials meta-analysis |
| url | http://dx.doi.org/10.1080/09546634.2022.2091101 |
| work_keys_str_mv | AT lifengchen probioticsforthepreventionofatopicdermatitisininfantsfromdifferentgeographicregionsasystematicreviewandmetaanalysis AT yongshanni probioticsforthepreventionofatopicdermatitisininfantsfromdifferentgeographicregionsasystematicreviewandmetaanalysis AT xingdongwu probioticsforthepreventionofatopicdermatitisininfantsfromdifferentgeographicregionsasystematicreviewandmetaanalysis AT guixiachen probioticsforthepreventionofatopicdermatitisininfantsfromdifferentgeographicregionsasystematicreviewandmetaanalysis |