Kaposi's sarcoma-associated herpesvirus at 27
Kaposi's sarcoma-associated herpesvirus (KSHV) was discovered 27 years ago and its link to several pathologies – Kaposi's sarcoma, primary effusion lymphoma, and the B cell variant of Multicentric Castleman disease – is now well established. However, many questions remain about how KSHV ca...
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2021-12-01
|
| Series: | Tumour Virus Research |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666679021000136 |
| _version_ | 1818459996815360000 |
|---|---|
| author | Marta Maria Gaglia |
| author_facet | Marta Maria Gaglia |
| author_sort | Marta Maria Gaglia |
| collection | DOAJ |
| description | Kaposi's sarcoma-associated herpesvirus (KSHV) was discovered 27 years ago and its link to several pathologies – Kaposi's sarcoma, primary effusion lymphoma, and the B cell variant of Multicentric Castleman disease – is now well established. However, many questions remain about how KSHV causes tumors. Here, I will review studies from the last few years (primarily 2019–2021) that report new information about KSHV biology and tumorigenesis, including new results about KSHV proteins implicated in tumorigenesis, genetic and environmental variability in KSHV-related tumor development, and potential vulnerabilities of KSHV-caused tumors that could be novel therapeutic targets. |
| first_indexed | 2024-12-14T23:23:14Z |
| format | Article |
| id | doaj.art-a921c7a3df874c58af4ae65384952e45 |
| institution | Directory Open Access Journal |
| issn | 2666-6790 |
| language | English |
| last_indexed | 2024-12-14T23:23:14Z |
| publishDate | 2021-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Tumour Virus Research |
| spelling | doaj.art-a921c7a3df874c58af4ae65384952e452022-12-21T22:43:53ZengElsevierTumour Virus Research2666-67902021-12-0112200223Kaposi's sarcoma-associated herpesvirus at 27Marta Maria Gaglia0Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, MA, 02111, USAKaposi's sarcoma-associated herpesvirus (KSHV) was discovered 27 years ago and its link to several pathologies – Kaposi's sarcoma, primary effusion lymphoma, and the B cell variant of Multicentric Castleman disease – is now well established. However, many questions remain about how KSHV causes tumors. Here, I will review studies from the last few years (primarily 2019–2021) that report new information about KSHV biology and tumorigenesis, including new results about KSHV proteins implicated in tumorigenesis, genetic and environmental variability in KSHV-related tumor development, and potential vulnerabilities of KSHV-caused tumors that could be novel therapeutic targets.http://www.sciencedirect.com/science/article/pii/S2666679021000136KSHVHHV-8Kaposi's sarcomaPELViral oncogenesis |
| spellingShingle | Marta Maria Gaglia Kaposi's sarcoma-associated herpesvirus at 27 Tumour Virus Research KSHV HHV-8 Kaposi's sarcoma PEL Viral oncogenesis |
| title | Kaposi's sarcoma-associated herpesvirus at 27 |
| title_full | Kaposi's sarcoma-associated herpesvirus at 27 |
| title_fullStr | Kaposi's sarcoma-associated herpesvirus at 27 |
| title_full_unstemmed | Kaposi's sarcoma-associated herpesvirus at 27 |
| title_short | Kaposi's sarcoma-associated herpesvirus at 27 |
| title_sort | kaposi s sarcoma associated herpesvirus at 27 |
| topic | KSHV HHV-8 Kaposi's sarcoma PEL Viral oncogenesis |
| url | http://www.sciencedirect.com/science/article/pii/S2666679021000136 |
| work_keys_str_mv | AT martamariagaglia kaposissarcomaassociatedherpesvirusat27 |