ICAM-1 Kilifi variant is not associated with cerebral and severe malaria pathogenesis in Beninese children
Abstract Background Cytoadhesion and sequestration of Plasmodium falciparum infected red blood cells (iRBC) in the microvasculature of vital organs are a major cause of malaria pathology. Several studies have provided evidence on the implication of the human host intercellular adhesion molecule-1 (I...
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| Format: | Article |
| Language: | English |
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BMC
2022-04-01
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| Series: | Malaria Journal |
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| Online Access: | https://doi.org/10.1186/s12936-022-04139-0 |
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| author | Samuel Odarkwei Blankson Danielle Seri Dadjé Nadjla Traikia Maroufou J. Alao Serge Ayivi Annick Amoussou Philippe Deloron Nicaise Tuikue Ndam Jacqueline Milet Leonardo K. Basco Yaw Aniweh Rachida Tahar |
| author_facet | Samuel Odarkwei Blankson Danielle Seri Dadjé Nadjla Traikia Maroufou J. Alao Serge Ayivi Annick Amoussou Philippe Deloron Nicaise Tuikue Ndam Jacqueline Milet Leonardo K. Basco Yaw Aniweh Rachida Tahar |
| author_sort | Samuel Odarkwei Blankson |
| collection | DOAJ |
| description | Abstract Background Cytoadhesion and sequestration of Plasmodium falciparum infected red blood cells (iRBC) in the microvasculature of vital organs are a major cause of malaria pathology. Several studies have provided evidence on the implication of the human host intercellular adhesion molecule-1 (ICAM-1) as a major receptor for iRBCs binding to P. falciparum erythrocyte membrane protein 1 (PfEMP1) in the development of severe and cerebral malaria. The genetic polymorphism K29M in the immunoglobulin-like domain of ICAM-1, known as ICAM-1Kilifi, has been associated with either increased or decreased risk of developing cerebral malaria. Methods To provide more conclusive results, the genetic polymorphism of ICAM-1Kilifi was assessed by PCR and sequencing in blood samples from 215 Beninese children who presented with either mild or severe malaria including cerebral malaria. Results and conclusions The results showed that in this cohort of Beninese children, the ICAM-1kilifi variant is present at the frequencies of 0.27, similar to the frequency observed in other African countries. This ICAM-1kilifi variant was not associated with disease severity in agreement with other findings from the Gambia, Tanzania, Malawi, Gabon, and Thailand, suggesting no evidence of a direct link between this polymorphism and the pathogenesis of severe and cerebral malaria. |
| first_indexed | 2024-12-21T14:38:52Z |
| format | Article |
| id | doaj.art-a921e6b592b143e9b4b04be79d63b91f |
| institution | Directory Open Access Journal |
| issn | 1475-2875 |
| language | English |
| last_indexed | 2024-12-21T14:38:52Z |
| publishDate | 2022-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Malaria Journal |
| spelling | doaj.art-a921e6b592b143e9b4b04be79d63b91f2022-12-21T19:00:16ZengBMCMalaria Journal1475-28752022-04-012111610.1186/s12936-022-04139-0ICAM-1 Kilifi variant is not associated with cerebral and severe malaria pathogenesis in Beninese childrenSamuel Odarkwei Blankson0Danielle Seri Dadjé1Nadjla Traikia2Maroufou J. Alao3Serge Ayivi4Annick Amoussou5Philippe Deloron6Nicaise Tuikue Ndam7Jacqueline Milet8Leonardo K. Basco9Yaw Aniweh10Rachida Tahar11West African Centre for Cell Biology of Infectious Pathogens, Department of Biochemistry, Cell and Molecular Biology, College of Basic and Applied Sciences, University of GhanaUniversité de Paris, MERIT, IRDUniversité de Paris, MERIT, IRDPediatric Department, Centre Hospitalier Universitaire Mère-Enfant La Lagune (CHUMEL)Pediatric Department, Centre National Hospitalo-Universitaire (CNHU)Pediatric Department, Centre Hospitalo-Universitaire, Suruléré (CHU-Suruléré)Université de Paris, MERIT, IRDUniversité de Paris, MERIT, IRDUniversité de Paris, MERIT, IRDAix-Marseille Univ, IRD, AP-HM, SSA, VITROME, IHU–Méditerranée InfectionWest African Centre for Cell Biology of Infectious Pathogens, Department of Biochemistry, Cell and Molecular Biology, College of Basic and Applied Sciences, University of GhanaUniversité de Paris, MERIT, IRDAbstract Background Cytoadhesion and sequestration of Plasmodium falciparum infected red blood cells (iRBC) in the microvasculature of vital organs are a major cause of malaria pathology. Several studies have provided evidence on the implication of the human host intercellular adhesion molecule-1 (ICAM-1) as a major receptor for iRBCs binding to P. falciparum erythrocyte membrane protein 1 (PfEMP1) in the development of severe and cerebral malaria. The genetic polymorphism K29M in the immunoglobulin-like domain of ICAM-1, known as ICAM-1Kilifi, has been associated with either increased or decreased risk of developing cerebral malaria. Methods To provide more conclusive results, the genetic polymorphism of ICAM-1Kilifi was assessed by PCR and sequencing in blood samples from 215 Beninese children who presented with either mild or severe malaria including cerebral malaria. Results and conclusions The results showed that in this cohort of Beninese children, the ICAM-1kilifi variant is present at the frequencies of 0.27, similar to the frequency observed in other African countries. This ICAM-1kilifi variant was not associated with disease severity in agreement with other findings from the Gambia, Tanzania, Malawi, Gabon, and Thailand, suggesting no evidence of a direct link between this polymorphism and the pathogenesis of severe and cerebral malaria.https://doi.org/10.1186/s12936-022-04139-0Plasmodium falciparumMalariacerebral malariaPolymorphismICAM-1ICAM-1kilifi |
| spellingShingle | Samuel Odarkwei Blankson Danielle Seri Dadjé Nadjla Traikia Maroufou J. Alao Serge Ayivi Annick Amoussou Philippe Deloron Nicaise Tuikue Ndam Jacqueline Milet Leonardo K. Basco Yaw Aniweh Rachida Tahar ICAM-1 Kilifi variant is not associated with cerebral and severe malaria pathogenesis in Beninese children Malaria Journal Plasmodium falciparum Malaria cerebral malaria Polymorphism ICAM-1 ICAM-1kilifi |
| title | ICAM-1 Kilifi variant is not associated with cerebral and severe malaria pathogenesis in Beninese children |
| title_full | ICAM-1 Kilifi variant is not associated with cerebral and severe malaria pathogenesis in Beninese children |
| title_fullStr | ICAM-1 Kilifi variant is not associated with cerebral and severe malaria pathogenesis in Beninese children |
| title_full_unstemmed | ICAM-1 Kilifi variant is not associated with cerebral and severe malaria pathogenesis in Beninese children |
| title_short | ICAM-1 Kilifi variant is not associated with cerebral and severe malaria pathogenesis in Beninese children |
| title_sort | icam 1 kilifi variant is not associated with cerebral and severe malaria pathogenesis in beninese children |
| topic | Plasmodium falciparum Malaria cerebral malaria Polymorphism ICAM-1 ICAM-1kilifi |
| url | https://doi.org/10.1186/s12936-022-04139-0 |
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