Malus domestica reduces chemotherapy-induced nausea and vomiting: A randomized double-blind placebo-controlled clinical trial
Background: Chemotherapy-induced nausea and vomiting (CINV) is considered as the most common complications of chemotherapy which has a detrimental influence on the quality of life of patients with cancer. We assessed the efficacy of Apple (Malus domestica) syrup for reducing CINV. Materials and Meth...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2021-01-01
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| Series: | Journal of Research in Medical Sciences |
| Subjects: | |
| Online Access: | http://www.jmsjournal.net/article.asp?issn=1735-1995;year=2021;volume=26;issue=1;spage=72;epage=72;aulast=Darvishpour |
| _version_ | 1818407048128233472 |
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| author | Sharareh Darvishpour Razieh Avan Mohammad Azadbakht Monireh Maham Jafar Akbari Ghasem Janbabaei Ehsan Zaboli Ali Reza Amirabadizadeh Ebrahim Salehifar |
| author_facet | Sharareh Darvishpour Razieh Avan Mohammad Azadbakht Monireh Maham Jafar Akbari Ghasem Janbabaei Ehsan Zaboli Ali Reza Amirabadizadeh Ebrahim Salehifar |
| author_sort | Sharareh Darvishpour |
| collection | DOAJ |
| description | Background: Chemotherapy-induced nausea and vomiting (CINV) is considered as the most common complications of chemotherapy which has a detrimental influence on the quality of life of patients with cancer. We assessed the efficacy of Apple (Malus domestica) syrup for reducing CINV. Materials and Methods: This study was a randomized, double-blind, placebo-controlled trial carried out in a Hematooncology Clinic affiliated to Mazandaran University of Medical Sciences, Sari, Iran (from October 2017 to August 2018). Subjects were randomly allocated to receive apple syrup or placebo along with their previous antiemetic treatment and chemotherapy regimen, three times a day. Thirty-four patients received apple syrup (n = 16) or placebo (n = 18). Statistical analysis was conducted using SPSS software Version 21® (SPSS Inc., Chicago, IL, USA). A P < 0.05 indicated statistical significance. Results: Both acute and delayed nausea grades were significantly lower in M. domestica syrup in comparison to placebo syrup (P = 0.001 and 0.001, respectively). The duration of nausea (P = 0.04) was lower in intervention group compared to placebo group. Conclusion: These findings demonstrated that M. domestica syrup can reduce the severity and duration of nausea in cancer patients who received chemotherapy. |
| first_indexed | 2024-12-14T09:21:38Z |
| format | Article |
| id | doaj.art-a922135d08e74133b7d532f7fca65939 |
| institution | Directory Open Access Journal |
| issn | 1735-1995 1735-7136 |
| language | English |
| last_indexed | 2024-12-14T09:21:38Z |
| publishDate | 2021-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Research in Medical Sciences |
| spelling | doaj.art-a922135d08e74133b7d532f7fca659392022-12-21T23:08:18ZengWolters Kluwer Medknow PublicationsJournal of Research in Medical Sciences1735-19951735-71362021-01-01261727210.4103/jrms.JRMS_833_20Malus domestica reduces chemotherapy-induced nausea and vomiting: A randomized double-blind placebo-controlled clinical trialSharareh DarvishpourRazieh AvanMohammad AzadbakhtMonireh MahamJafar AkbariGhasem JanbabaeiEhsan ZaboliAli Reza AmirabadizadehEbrahim SalehifarBackground: Chemotherapy-induced nausea and vomiting (CINV) is considered as the most common complications of chemotherapy which has a detrimental influence on the quality of life of patients with cancer. We assessed the efficacy of Apple (Malus domestica) syrup for reducing CINV. Materials and Methods: This study was a randomized, double-blind, placebo-controlled trial carried out in a Hematooncology Clinic affiliated to Mazandaran University of Medical Sciences, Sari, Iran (from October 2017 to August 2018). Subjects were randomly allocated to receive apple syrup or placebo along with their previous antiemetic treatment and chemotherapy regimen, three times a day. Thirty-four patients received apple syrup (n = 16) or placebo (n = 18). Statistical analysis was conducted using SPSS software Version 21® (SPSS Inc., Chicago, IL, USA). A P < 0.05 indicated statistical significance. Results: Both acute and delayed nausea grades were significantly lower in M. domestica syrup in comparison to placebo syrup (P = 0.001 and 0.001, respectively). The duration of nausea (P = 0.04) was lower in intervention group compared to placebo group. Conclusion: These findings demonstrated that M. domestica syrup can reduce the severity and duration of nausea in cancer patients who received chemotherapy.http://www.jmsjournal.net/article.asp?issn=1735-1995;year=2021;volume=26;issue=1;spage=72;epage=72;aulast=Darvishpourchemotherapy-induced nausea and vomitingmalus domesticapalliative carequality of liferandomized controlled trial |
| spellingShingle | Sharareh Darvishpour Razieh Avan Mohammad Azadbakht Monireh Maham Jafar Akbari Ghasem Janbabaei Ehsan Zaboli Ali Reza Amirabadizadeh Ebrahim Salehifar Malus domestica reduces chemotherapy-induced nausea and vomiting: A randomized double-blind placebo-controlled clinical trial Journal of Research in Medical Sciences chemotherapy-induced nausea and vomiting malus domestica palliative care quality of life randomized controlled trial |
| title | Malus domestica reduces chemotherapy-induced nausea and vomiting: A randomized double-blind placebo-controlled clinical trial |
| title_full | Malus domestica reduces chemotherapy-induced nausea and vomiting: A randomized double-blind placebo-controlled clinical trial |
| title_fullStr | Malus domestica reduces chemotherapy-induced nausea and vomiting: A randomized double-blind placebo-controlled clinical trial |
| title_full_unstemmed | Malus domestica reduces chemotherapy-induced nausea and vomiting: A randomized double-blind placebo-controlled clinical trial |
| title_short | Malus domestica reduces chemotherapy-induced nausea and vomiting: A randomized double-blind placebo-controlled clinical trial |
| title_sort | malus domestica reduces chemotherapy induced nausea and vomiting a randomized double blind placebo controlled clinical trial |
| topic | chemotherapy-induced nausea and vomiting malus domestica palliative care quality of life randomized controlled trial |
| url | http://www.jmsjournal.net/article.asp?issn=1735-1995;year=2021;volume=26;issue=1;spage=72;epage=72;aulast=Darvishpour |
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