A novel nuclear receptor subfamily enlightens the origin of heterodimerization

A novel nuclear receptor subfamily enlightens the origin of heterodimerization

Abstract Background Nuclear receptors are transcription factors of central importance in human biology and associated diseases. Much of the knowledge related to their major functions, such as ligand and DNA binding or dimerization, derives from functional studies undertaken in classical model animal...

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Main Authors: Brice Beinsteiner, Gabriel V. Markov, Maxime Bourguet, Alastair G. McEwen, Stéphane Erb, Abdul Kareem Mohideen Patel, Fatima Z. El Khaloufi El Khaddar, Claire Lecroisey, Guillaume Holzer, Karim Essabri, Isabelle Hazemann, Ali Hamiche, Sarah Cianférani, Dino Moras, Vincent Laudet, Isabelle M. L. Billas
Format: Article
Language:English
Published: BMC 2022-10-01
Series:BMC Biology
Subjects:
Amphioxus
Non-model animals
Nuclear receptor phylogeny
Nuclear receptor dimerization
NR7; Crystal structure; Native mass spectrometry
Online Access:https://doi.org/10.1186/s12915-022-01413-0

Internet

https://doi.org/10.1186/s12915-022-01413-0

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