Cdk5 is required for memory function and hippocampal plasticity via the cAMP signaling pathway.

Cdk5 is required for memory function and hippocampal plasticity via the cAMP signaling pathway.

Memory formation is modulated by pre- and post-synaptic signaling events in neurons. The neuronal protein kinase Cyclin-Dependent Kinase 5 (Cdk5) phosphorylates a variety of synaptic substrates and is implicated in memory formation. It has also been shown to play a role in homeostatic regulation of...

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Bibliographic Details
Main Authors: Ji-Song Guan, Susan C Su, Jun Gao, Nadine Joseph, Zhigang Xie, Ying Zhou, Omer Durak, Lei Zhang, J Julius Zhu, Karl R Clauser, Steven A Carr, Li-Huei Tsai
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3184170?pdf=render

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