Immunomodulatory Function of Vitamin D and Its Role in Autoimmune Thyroid Disease
Vitamin D is one of the most important nutrients required by the human body. It is a steroid hormone that plays an important role in regulating calcium and phosphorus metabolism, and bone health. Epidemiological studies have revealed a close correlation between vitamin D and many common chronic dise...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-02-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2021.574967/full |
| _version_ | 1831804399127625728 |
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| author | Rui Zhao Wei Zhang Chenghong Ma Yaping Zhao Rong Xiong Hanmin Wang Weiwen Chen Song Guo Zheng |
| author_facet | Rui Zhao Wei Zhang Chenghong Ma Yaping Zhao Rong Xiong Hanmin Wang Weiwen Chen Song Guo Zheng |
| author_sort | Rui Zhao |
| collection | DOAJ |
| description | Vitamin D is one of the most important nutrients required by the human body. It is a steroid hormone that plays an important role in regulating calcium and phosphorus metabolism, and bone health. Epidemiological studies have revealed a close correlation between vitamin D and many common chronic diseases. Additionally, vitamin D has recently been shown to act as an immunomodulatory hormone, and, accordingly, vitamin D deficiency was uncovered as a risk factor for autoimmune thyroid diseases, although the underlying mechanisms are still unknown. It is therefore necessary to disclose the role and mechanism of action of vitamin D in the occurrence and development of autoimmune thyroid diseases. This knowledge will help design intervention and early treatment strategies for patients with autoimmune thyroid diseases who present with low levels of vitamin D. |
| first_indexed | 2024-12-22T19:05:40Z |
| format | Article |
| id | doaj.art-a92513e6475140eea2c0244ac5cbfd4d |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-22T19:05:40Z |
| publishDate | 2021-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-a92513e6475140eea2c0244ac5cbfd4d2022-12-21T18:15:50ZengFrontiers Media S.A.Frontiers in Immunology1664-32242021-02-011210.3389/fimmu.2021.574967574967Immunomodulatory Function of Vitamin D and Its Role in Autoimmune Thyroid DiseaseRui Zhao0Wei Zhang1Chenghong Ma2Yaping Zhao3Rong Xiong4Hanmin Wang5Weiwen Chen6Song Guo Zheng7Department of Endocrinology, Qujing Affiliated Hospital of Kunming Medical University, Kunming, ChinaDepartment of Endocrinology, Qujing Affiliated Hospital of Kunming Medical University, Kunming, ChinaDepartment of Endocrinology, Qujing Affiliated Hospital of Kunming Medical University, Kunming, ChinaDepartment of Endocrinology, Qujing Affiliated Hospital of Kunming Medical University, Kunming, ChinaDepartment of Endocrinology, Qujing Affiliated Hospital of Kunming Medical University, Kunming, ChinaDepartment of Endocrinology, Qujing Affiliated Hospital of Kunming Medical University, Kunming, ChinaDepartment of Endocrinology, Qujing Affiliated Hospital of Kunming Medical University, Kunming, ChinaDivision of Immunology and Rheumatology, Ohio State University Wexner Medical Center and College of Medicine, Columbus, OH, United StatesVitamin D is one of the most important nutrients required by the human body. It is a steroid hormone that plays an important role in regulating calcium and phosphorus metabolism, and bone health. Epidemiological studies have revealed a close correlation between vitamin D and many common chronic diseases. Additionally, vitamin D has recently been shown to act as an immunomodulatory hormone, and, accordingly, vitamin D deficiency was uncovered as a risk factor for autoimmune thyroid diseases, although the underlying mechanisms are still unknown. It is therefore necessary to disclose the role and mechanism of action of vitamin D in the occurrence and development of autoimmune thyroid diseases. This knowledge will help design intervention and early treatment strategies for patients with autoimmune thyroid diseases who present with low levels of vitamin D.https://www.frontiersin.org/articles/10.3389/fimmu.2021.574967/fullvitamin Dimmunomodulatory functionautoimmune thyroid diseaseHashimoto autoimmune thyroiditisGrave's disease |
| spellingShingle | Rui Zhao Wei Zhang Chenghong Ma Yaping Zhao Rong Xiong Hanmin Wang Weiwen Chen Song Guo Zheng Immunomodulatory Function of Vitamin D and Its Role in Autoimmune Thyroid Disease Frontiers in Immunology vitamin D immunomodulatory function autoimmune thyroid disease Hashimoto autoimmune thyroiditis Grave's disease |
| title | Immunomodulatory Function of Vitamin D and Its Role in Autoimmune Thyroid Disease |
| title_full | Immunomodulatory Function of Vitamin D and Its Role in Autoimmune Thyroid Disease |
| title_fullStr | Immunomodulatory Function of Vitamin D and Its Role in Autoimmune Thyroid Disease |
| title_full_unstemmed | Immunomodulatory Function of Vitamin D and Its Role in Autoimmune Thyroid Disease |
| title_short | Immunomodulatory Function of Vitamin D and Its Role in Autoimmune Thyroid Disease |
| title_sort | immunomodulatory function of vitamin d and its role in autoimmune thyroid disease |
| topic | vitamin D immunomodulatory function autoimmune thyroid disease Hashimoto autoimmune thyroiditis Grave's disease |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2021.574967/full |
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