Intra‐ischemic hypothermia cardioprotection involves modulation of PTEN/Akt/ERK signaling and fatty acid oxidation

Abstract Therapeutic hypothermia (TH) provides cardioprotection from ischemia/reperfusion (I/R) injury. However, it remains unknown how TH regulates metabolic recovery. We tested the hypothesis that TH modulates PTEN, Akt, and ERK1/2, and improves metabolic recovery through mitigation of fatty acid...

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Bibliographic Details
Main Authors: Cody N. Justice, Xiangdong Zhu, Jing Li, J. Michael O'Donnell, Terry L. Vanden Hoek
Format: Article
Language:English
Published: Wiley 2023-02-01
Series:Physiological Reports
Subjects:
Online Access:https://doi.org/10.14814/phy2.15611