Implications of siRNA Therapy in Bone Health: Silencing Communicates
The global statistics of bone disorders, skeletal defects, and fractures are frightening. Several therapeutic strategies are being used to fix them; however, RNAi-based siRNA therapy is starting to prove to be a promising approach for the prevention of bone disorders because of its advanced capabili...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-01-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/12/1/90 |
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| author | Puneetpal Singh Monica Singh Baani Singh Kirti Sharma Nitin Kumar Deepinder Singh Harpal Singh Klair Sarabjit Mastana |
| author_facet | Puneetpal Singh Monica Singh Baani Singh Kirti Sharma Nitin Kumar Deepinder Singh Harpal Singh Klair Sarabjit Mastana |
| author_sort | Puneetpal Singh |
| collection | DOAJ |
| description | The global statistics of bone disorders, skeletal defects, and fractures are frightening. Several therapeutic strategies are being used to fix them; however, RNAi-based siRNA therapy is starting to prove to be a promising approach for the prevention of bone disorders because of its advanced capabilities to deliver siRNA or siRNA drug conjugate to the target tissue. Despite its ‘bench-to-bedside’ usefulness and approval by food and drug administration for five siRNA-based therapeutic medicines: Patisiran, Vutrisiran, Inclisiran, Lumasiran, and Givosiran, its use for the other diseases still remains to be resolved. By correcting the complications and complexities involved in siRNA delivery for its sustained release, better absorption, and toxicity-free activity, siRNA therapy can be harnessed as an experimental tool for the prevention of complex and undruggable diseases with a personalized medicine approach. The present review summarizes the findings of notable research to address the implications of siRNA in bone health for the restoration of bone mass, recovery of bone loss, and recuperation of bone fractures. |
| first_indexed | 2024-03-08T09:58:03Z |
| format | Article |
| id | doaj.art-a928219e28a94861b6cb32e1b6114914 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-08T09:58:03Z |
| publishDate | 2024-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-a928219e28a94861b6cb32e1b61149142024-01-29T13:47:02ZengMDPI AGBiomedicines2227-90592024-01-011219010.3390/biomedicines12010090Implications of siRNA Therapy in Bone Health: Silencing CommunicatesPuneetpal Singh0Monica Singh1Baani Singh2Kirti Sharma3Nitin Kumar4Deepinder Singh5Harpal Singh Klair6Sarabjit Mastana7Department of Human Genetics, Punjabi University, Patiala 147002, Punjab, IndiaDepartment of Human Genetics, Punjabi University, Patiala 147002, Punjab, IndiaDepartment of Human Genetics, Punjabi University, Patiala 147002, Punjab, IndiaDepartment of Human Genetics, Punjabi University, Patiala 147002, Punjab, IndiaDepartment of Human Genetics, Punjabi University, Patiala 147002, Punjab, IndiaVardhman Mahavir Health Care, Urban Estate, Ph-II, Patiala 147002, Punjab, IndiaKlair Orthopaedic Centre, Punjabi Bagh, Patiala 147001, Punjab, IndiaHuman Genomics Laboratory, School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough LE11 3TU, UKThe global statistics of bone disorders, skeletal defects, and fractures are frightening. Several therapeutic strategies are being used to fix them; however, RNAi-based siRNA therapy is starting to prove to be a promising approach for the prevention of bone disorders because of its advanced capabilities to deliver siRNA or siRNA drug conjugate to the target tissue. Despite its ‘bench-to-bedside’ usefulness and approval by food and drug administration for five siRNA-based therapeutic medicines: Patisiran, Vutrisiran, Inclisiran, Lumasiran, and Givosiran, its use for the other diseases still remains to be resolved. By correcting the complications and complexities involved in siRNA delivery for its sustained release, better absorption, and toxicity-free activity, siRNA therapy can be harnessed as an experimental tool for the prevention of complex and undruggable diseases with a personalized medicine approach. The present review summarizes the findings of notable research to address the implications of siRNA in bone health for the restoration of bone mass, recovery of bone loss, and recuperation of bone fractures.https://www.mdpi.com/2227-9059/12/1/90RNAisiRNA therapybone disorderssiRNA delivery |
| spellingShingle | Puneetpal Singh Monica Singh Baani Singh Kirti Sharma Nitin Kumar Deepinder Singh Harpal Singh Klair Sarabjit Mastana Implications of siRNA Therapy in Bone Health: Silencing Communicates Biomedicines RNAi siRNA therapy bone disorders siRNA delivery |
| title | Implications of siRNA Therapy in Bone Health: Silencing Communicates |
| title_full | Implications of siRNA Therapy in Bone Health: Silencing Communicates |
| title_fullStr | Implications of siRNA Therapy in Bone Health: Silencing Communicates |
| title_full_unstemmed | Implications of siRNA Therapy in Bone Health: Silencing Communicates |
| title_short | Implications of siRNA Therapy in Bone Health: Silencing Communicates |
| title_sort | implications of sirna therapy in bone health silencing communicates |
| topic | RNAi siRNA therapy bone disorders siRNA delivery |
| url | https://www.mdpi.com/2227-9059/12/1/90 |
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