Log odds of negative lymph nodes/T stage ratio (LONT): A new prognostic tool for differentiated thyroid cancer without metastases in patients aged 55 and older
BackgroundThe optimal approach to assess the postoperative status of lymph nodes in differentiated thyroid cancer (DTC) remains controversial. Our aim was to determine if the log odds of negative lymph nodes/T stage ratio (LONT) could serve as a new prognostic and predictive tool for DTC without met...
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Frontiers Media S.A.
2023-03-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2023.1132687/full |
| _version_ | 1797865968555261952 |
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| author | Xuezhen Wang Xuezhen Wang Yufan Wu Yufan Wu Xiaoxia Li Xiaoxia Li Jinsheng Hong Jinsheng Hong Jinsheng Hong Mingwei Zhang Mingwei Zhang Mingwei Zhang |
| author_facet | Xuezhen Wang Xuezhen Wang Yufan Wu Yufan Wu Xiaoxia Li Xiaoxia Li Jinsheng Hong Jinsheng Hong Jinsheng Hong Mingwei Zhang Mingwei Zhang Mingwei Zhang |
| author_sort | Xuezhen Wang |
| collection | DOAJ |
| description | BackgroundThe optimal approach to assess the postoperative status of lymph nodes in differentiated thyroid cancer (DTC) remains controversial. Our aim was to determine if the log odds of negative lymph nodes/T stage ratio (LONT) could serve as a new prognostic and predictive tool for DTC without metastases in patients aged ≥ 55 years.MethodsThe Surveillance, Epidemiology, and End Results (SEER) database was used to study the role of LONT in patients aged ≥55 years diagnosed with DTC without metastases. The primary outcome was overall survival (OS). The Kaplan-Meier method and the Cox proportional hazard regression model were used to calculate the outcome. Moreover, the robustness of research findings was evaluated using sensitivity analyses.ResultsA total of 21,172 DTC patients aged ≥55 years without distant metastasis were enrolled. Multivariate Cox regression analyses and a “floating absolute risk” analysis showed that a LONT ≥0.920 (vs. -0.56 to 0.92) was a protective factor for OS in DTC patients. Sensitivity analyses revealed an E-value of 1.98 for the obtained LONT value. In subgroup analyses, LONT was correlated significantly with OS in different subgroups of negative lymph nodes, stage-I–II subgroups and the N0 subgroup. The conditional probability of survival of DTC improved with prolonged survival time in the LONT ≥0.920 group.ConclusionA high LONT was associated with longer OS compared with low LONT in patients aged ≥55 years with non-metastatic DTC. LONT could provide valuable information for undertaking postoperative evaluations. |
| first_indexed | 2024-04-09T23:16:41Z |
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| id | doaj.art-a92896129d0c4ab8847f957636bf605b |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-04-09T23:16:41Z |
| publishDate | 2023-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-a92896129d0c4ab8847f957636bf605b2023-03-22T06:13:27ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922023-03-011410.3389/fendo.2023.11326871132687Log odds of negative lymph nodes/T stage ratio (LONT): A new prognostic tool for differentiated thyroid cancer without metastases in patients aged 55 and olderXuezhen Wang0Xuezhen Wang1Yufan Wu2Yufan Wu3Xiaoxia Li4Xiaoxia Li5Jinsheng Hong6Jinsheng Hong7Jinsheng Hong8Mingwei Zhang9Mingwei Zhang10Mingwei Zhang11Department of Radiotherapy, Cancer Center, The First Affiliated Hospital of Fujian Medical University, Fuzhou, ChinaDepartment of Radiotherapy, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, ChinaDepartment of Radiotherapy, Cancer Center, The First Affiliated Hospital of Fujian Medical University, Fuzhou, ChinaDepartment of Radiotherapy, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, ChinaDepartment of Radiotherapy, Cancer Center, The First Affiliated Hospital of Fujian Medical University, Fuzhou, ChinaDepartment of Radiotherapy, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, ChinaDepartment of Radiotherapy, Cancer Center, The First Affiliated Hospital of Fujian Medical University, Fuzhou, ChinaDepartment of Radiotherapy, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, ChinaKey Laboratory of Radiation Biology of Fujian Higher Education Institutions, The First Affiliated Hospital, Fujian Medical University, Fuzhou, ChinaDepartment of Radiotherapy, Cancer Center, The First Affiliated Hospital of Fujian Medical University, Fuzhou, ChinaDepartment of Radiotherapy, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, ChinaKey Laboratory of Radiation Biology of Fujian Higher Education Institutions, The First Affiliated Hospital, Fujian Medical University, Fuzhou, ChinaBackgroundThe optimal approach to assess the postoperative status of lymph nodes in differentiated thyroid cancer (DTC) remains controversial. Our aim was to determine if the log odds of negative lymph nodes/T stage ratio (LONT) could serve as a new prognostic and predictive tool for DTC without metastases in patients aged ≥ 55 years.MethodsThe Surveillance, Epidemiology, and End Results (SEER) database was used to study the role of LONT in patients aged ≥55 years diagnosed with DTC without metastases. The primary outcome was overall survival (OS). The Kaplan-Meier method and the Cox proportional hazard regression model were used to calculate the outcome. Moreover, the robustness of research findings was evaluated using sensitivity analyses.ResultsA total of 21,172 DTC patients aged ≥55 years without distant metastasis were enrolled. Multivariate Cox regression analyses and a “floating absolute risk” analysis showed that a LONT ≥0.920 (vs. -0.56 to 0.92) was a protective factor for OS in DTC patients. Sensitivity analyses revealed an E-value of 1.98 for the obtained LONT value. In subgroup analyses, LONT was correlated significantly with OS in different subgroups of negative lymph nodes, stage-I–II subgroups and the N0 subgroup. The conditional probability of survival of DTC improved with prolonged survival time in the LONT ≥0.920 group.ConclusionA high LONT was associated with longer OS compared with low LONT in patients aged ≥55 years with non-metastatic DTC. LONT could provide valuable information for undertaking postoperative evaluations.https://www.frontiersin.org/articles/10.3389/fendo.2023.1132687/fullDTCLONTnegative lymph nodesnegative lymph nodes/T stageprognosis |
| spellingShingle | Xuezhen Wang Xuezhen Wang Yufan Wu Yufan Wu Xiaoxia Li Xiaoxia Li Jinsheng Hong Jinsheng Hong Jinsheng Hong Mingwei Zhang Mingwei Zhang Mingwei Zhang Log odds of negative lymph nodes/T stage ratio (LONT): A new prognostic tool for differentiated thyroid cancer without metastases in patients aged 55 and older Frontiers in Endocrinology DTC LONT negative lymph nodes negative lymph nodes/T stage prognosis |
| title | Log odds of negative lymph nodes/T stage ratio (LONT): A new prognostic tool for differentiated thyroid cancer without metastases in patients aged 55 and older |
| title_full | Log odds of negative lymph nodes/T stage ratio (LONT): A new prognostic tool for differentiated thyroid cancer without metastases in patients aged 55 and older |
| title_fullStr | Log odds of negative lymph nodes/T stage ratio (LONT): A new prognostic tool for differentiated thyroid cancer without metastases in patients aged 55 and older |
| title_full_unstemmed | Log odds of negative lymph nodes/T stage ratio (LONT): A new prognostic tool for differentiated thyroid cancer without metastases in patients aged 55 and older |
| title_short | Log odds of negative lymph nodes/T stage ratio (LONT): A new prognostic tool for differentiated thyroid cancer without metastases in patients aged 55 and older |
| title_sort | log odds of negative lymph nodes t stage ratio lont a new prognostic tool for differentiated thyroid cancer without metastases in patients aged 55 and older |
| topic | DTC LONT negative lymph nodes negative lymph nodes/T stage prognosis |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2023.1132687/full |
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