Detailed Calorimetric Analysis of Mixed Micelle Formation from Aqueous Binary Surfactants for Design of Nanoscale Drug Carriers
While numerous papers have been published according to the binary surfactant mixtures, only a few articles provide deeper information on the composition dependence of the micellization, and even less work attempts to apply the enhanced feature of the mixed micelles. The most important parameter of t...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-12-01
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| Series: | Nanomaterials |
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| Online Access: | https://www.mdpi.com/2079-4991/11/12/3288 |
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| author | Ádám Juhász László Seres Norbert Varga Ditta Ungor Marek Wojnicki Edit Csapó |
| author_facet | Ádám Juhász László Seres Norbert Varga Ditta Ungor Marek Wojnicki Edit Csapó |
| author_sort | Ádám Juhász |
| collection | DOAJ |
| description | While numerous papers have been published according to the binary surfactant mixtures, only a few articles provide deeper information on the composition dependence of the micellization, and even less work attempts to apply the enhanced feature of the mixed micelles. The most important parameter of the self-assembled surfactants is the critical micelle concentration (<i>cmc</i>), which quantifies the tendency to associate, and provides the Gibbs energy of micellization. Several techniques are known for determining the <i>cmc</i>, but the isothermal titration calorimetry (ITC) can be used to measure both <i>cmc</i> and enthalpy change (Δ<i><sub>mic</sub>H</i>) accompanying micelle formation. Outcomes of our calorimetric investigations were evaluated using a self-developed routine for handling ITC data and the thermodynamic parameters of mixed micelle formation were obtained from the nonlinear modelling of temperature- and composition- dependent enthalpograms. In the investigated temperature and micelle mole fractions interval, we observed some intervals where the <i>cmc</i> is lower than the ideal mixing model predicted value. These equimolar binary surfactant mixtures showed higher solubilization ability for poorly water-soluble model drugs than their individual compounds. Thus, the rapid and fairly accurate calorimetric analysis of mixed micelles can lead to the successful design of a nanoscale drug carrier. |
| first_indexed | 2024-03-10T03:26:36Z |
| format | Article |
| id | doaj.art-a92adcc549b84f47b7cf39c941b07b6c |
| institution | Directory Open Access Journal |
| issn | 2079-4991 |
| language | English |
| last_indexed | 2024-03-10T03:26:36Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nanomaterials |
| spelling | doaj.art-a92adcc549b84f47b7cf39c941b07b6c2023-11-23T09:50:31ZengMDPI AGNanomaterials2079-49912021-12-011112328810.3390/nano11123288Detailed Calorimetric Analysis of Mixed Micelle Formation from Aqueous Binary Surfactants for Design of Nanoscale Drug CarriersÁdám Juhász0László Seres1Norbert Varga2Ditta Ungor3Marek Wojnicki4Edit Csapó5MTA-SZTE Lendület “Momentum” Noble Metal Nanostructures Research Group, Interdisciplinary Excellence Center, Department of Physical Chemistry and Materials Science, Faculty of Science and Informatics, University of Szeged, Rerrich Béla Square 1, H-6720 Szeged, HungaryMTA-SZTE Lendület “Momentum” Noble Metal Nanostructures Research Group, Interdisciplinary Excellence Center, Department of Physical Chemistry and Materials Science, Faculty of Science and Informatics, University of Szeged, Rerrich Béla Square 1, H-6720 Szeged, HungaryMTA-SZTE Lendület “Momentum” Noble Metal Nanostructures Research Group, Interdisciplinary Excellence Center, Department of Physical Chemistry and Materials Science, Faculty of Science and Informatics, University of Szeged, Rerrich Béla Square 1, H-6720 Szeged, HungaryMTA-SZTE Lendület “Momentum” Noble Metal Nanostructures Research Group, Interdisciplinary Excellence Center, Department of Physical Chemistry and Materials Science, Faculty of Science and Informatics, University of Szeged, Rerrich Béla Square 1, H-6720 Szeged, HungaryFaculty of Non-Ferrous Metals, AGH University of Science and Technology, Mickiewicza Ave. 30, 30-059 Krakow, PolandMTA-SZTE Lendület “Momentum” Noble Metal Nanostructures Research Group, Interdisciplinary Excellence Center, Department of Physical Chemistry and Materials Science, Faculty of Science and Informatics, University of Szeged, Rerrich Béla Square 1, H-6720 Szeged, HungaryWhile numerous papers have been published according to the binary surfactant mixtures, only a few articles provide deeper information on the composition dependence of the micellization, and even less work attempts to apply the enhanced feature of the mixed micelles. The most important parameter of the self-assembled surfactants is the critical micelle concentration (<i>cmc</i>), which quantifies the tendency to associate, and provides the Gibbs energy of micellization. Several techniques are known for determining the <i>cmc</i>, but the isothermal titration calorimetry (ITC) can be used to measure both <i>cmc</i> and enthalpy change (Δ<i><sub>mic</sub>H</i>) accompanying micelle formation. Outcomes of our calorimetric investigations were evaluated using a self-developed routine for handling ITC data and the thermodynamic parameters of mixed micelle formation were obtained from the nonlinear modelling of temperature- and composition- dependent enthalpograms. In the investigated temperature and micelle mole fractions interval, we observed some intervals where the <i>cmc</i> is lower than the ideal mixing model predicted value. These equimolar binary surfactant mixtures showed higher solubilization ability for poorly water-soluble model drugs than their individual compounds. Thus, the rapid and fairly accurate calorimetric analysis of mixed micelles can lead to the successful design of a nanoscale drug carrier.https://www.mdpi.com/2079-4991/11/12/3288mixed micellecalorimetrysolubilizationdrug delivery |
| spellingShingle | Ádám Juhász László Seres Norbert Varga Ditta Ungor Marek Wojnicki Edit Csapó Detailed Calorimetric Analysis of Mixed Micelle Formation from Aqueous Binary Surfactants for Design of Nanoscale Drug Carriers Nanomaterials mixed micelle calorimetry solubilization drug delivery |
| title | Detailed Calorimetric Analysis of Mixed Micelle Formation from Aqueous Binary Surfactants for Design of Nanoscale Drug Carriers |
| title_full | Detailed Calorimetric Analysis of Mixed Micelle Formation from Aqueous Binary Surfactants for Design of Nanoscale Drug Carriers |
| title_fullStr | Detailed Calorimetric Analysis of Mixed Micelle Formation from Aqueous Binary Surfactants for Design of Nanoscale Drug Carriers |
| title_full_unstemmed | Detailed Calorimetric Analysis of Mixed Micelle Formation from Aqueous Binary Surfactants for Design of Nanoscale Drug Carriers |
| title_short | Detailed Calorimetric Analysis of Mixed Micelle Formation from Aqueous Binary Surfactants for Design of Nanoscale Drug Carriers |
| title_sort | detailed calorimetric analysis of mixed micelle formation from aqueous binary surfactants for design of nanoscale drug carriers |
| topic | mixed micelle calorimetry solubilization drug delivery |
| url | https://www.mdpi.com/2079-4991/11/12/3288 |
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