The HEDGEHOG-GLI1 pathway is important for fibroproliferative properties in keloids and as a candidate therapeutic target
Abstract Keloids are benign fibroproliferative skin tumors caused by aberrant wound healing that can negatively impact patient quality of life. The lack of animal models has limited research on pathogenesis or developing effective treatments, and the etiology of keloids remains unknown. Here, we fou...
Main Authors: | Mamiko Tosa, Yoshinori Abe, Seiko Egawa, Tomoka Hatakeyama, Chihiro Iwaguro, Ryotaro Mitsugi, Ayaka Moriyama, Takumi Sano, Rei Ogawa, Nobuyuki Tanaka |
---|---|
Format: | Article |
Language: | English |
Published: |
Nature Portfolio
2023-12-01
|
Series: | Communications Biology |
Online Access: | https://doi.org/10.1038/s42003-023-05561-z |
Similar Items
-
Fibroproliferative disorders: report and discussion
on keloid management
by: Marcelus Vinicius de Araújo Santos Nigro, et al.
Published: (2020-12-01) -
Hedgehog-gli signaling in human disease /
by: 386831 Ruiz i Altaba, Ariel
Published: (2006) -
Comprehensive Ontology of Fibroproliferative Diseases: Protocol for a Semantic Technology Study
by: Marcin Golec, et al.
Published: (2023-08-01) -
Hedgehog Signaling and Truncated GLI1 in Cancer
by: Daniel Doheny, et al.
Published: (2020-09-01) -
Galunisertib Exerts Antifibrotic Effects on TGF-β-Induced Fibroproliferative Dermal Fibroblasts
by: Joshua M. Peterson, et al.
Published: (2022-06-01)