Controlled Synthesis of Up-Conversion NaYF<sub>4</sub>:Yb,Tm Nanoparticles for Drug Release under Near IR-Light Therapy
Up-Conversion materials have received great attention in drug delivery applications in recent years. A specifically emerging field includes the development of strategies focusing on photon processes that promote the development of novel platforms for the efficient transport and the controlled releas...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-12-01
|
| Series: | Biomedicines |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2227-9059/9/12/1953 |
| _version_ | 1797506462783635456 |
|---|---|
| author | Edelweiss Moyano Rodríguez Miguel Gomez-Mendoza Raúl Pérez-Ruiz Beatriz Peñín Diego Sampedro Antonio Caamaño Víctor A. de la Peña O’Shea |
| author_facet | Edelweiss Moyano Rodríguez Miguel Gomez-Mendoza Raúl Pérez-Ruiz Beatriz Peñín Diego Sampedro Antonio Caamaño Víctor A. de la Peña O’Shea |
| author_sort | Edelweiss Moyano Rodríguez |
| collection | DOAJ |
| description | Up-Conversion materials have received great attention in drug delivery applications in recent years. A specifically emerging field includes the development of strategies focusing on photon processes that promote the development of novel platforms for the efficient transport and the controlled release of drug molecules in the harsh microenvironment. Here, modified reaction time, thermal treatment, and pH conditions were controlled in the synthesis of NaYF<sub>4</sub>:Yb,Tm up-converted (UC) material to improve its photoluminescence properties. The best blue-emission performance was achieved for the UC3 sample prepared through 24 h-synthesis without thermal treatment at a pH of 5, which promotes the presence of the β-phase and smaller particle size. NaYF<sub>4</sub>:Yb,Tm has resulted in a highly efficient blue emitter material for light-driven drug release under near-IR wavelength. Thus, NaYF<sub>4</sub>:Yb,Tm up-converted material promotes the N-O bond cleavage of the oxime ester of Ciprofloxacin (prodrug) as a highly efficient photosensitized drug delivery process. HPLC chromatography and transient absorption spectroscopy measurements were performed to evaluate the drug release conversion rate. UC3 has resulted in a very stable and easily recovered material that can be used in several reaction cycles. This straightforward methodology can be extended to other drugs containing photoactive chromophores and is present as an alternative for drug release systems. |
| first_indexed | 2024-03-10T04:33:56Z |
| format | Article |
| id | doaj.art-a92d5ed6dabf4943a35051b4b900dee2 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-10T04:33:56Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-a92d5ed6dabf4943a35051b4b900dee22023-11-23T03:58:08ZengMDPI AGBiomedicines2227-90592021-12-01912195310.3390/biomedicines9121953Controlled Synthesis of Up-Conversion NaYF<sub>4</sub>:Yb,Tm Nanoparticles for Drug Release under Near IR-Light TherapyEdelweiss Moyano Rodríguez0Miguel Gomez-Mendoza1Raúl Pérez-Ruiz2Beatriz Peñín3Diego Sampedro4Antonio Caamaño5Víctor A. de la Peña O’Shea6Signal Theory and Communications and Telematic System and Computing, Rey Juan Carlos University, Cam/del Molino 5, 28942 Madrid, SpainPhotoactivated Processes Unit, IMDEA Energy Institute, C/Ramón de la Sagra, 3, 28935 Madrid, SpainPhotoactivated Processes Unit, IMDEA Energy Institute, C/Ramón de la Sagra, 3, 28935 Madrid, SpainDepartamento de Química, Centro de Investigación en Síntesis Química (CISQ), Universidad de La Rioja, Madre de Dios 53, 26006 Logroño, SpainDepartamento de Química, Centro de Investigación en Síntesis Química (CISQ), Universidad de La Rioja, Madre de Dios 53, 26006 Logroño, SpainSignal Theory and Communications and Telematic System and Computing, Rey Juan Carlos University, Cam/del Molino 5, 28942 Madrid, SpainPhotoactivated Processes Unit, IMDEA Energy Institute, C/Ramón de la Sagra, 3, 28935 Madrid, SpainUp-Conversion materials have received great attention in drug delivery applications in recent years. A specifically emerging field includes the development of strategies focusing on photon processes that promote the development of novel platforms for the efficient transport and the controlled release of drug molecules in the harsh microenvironment. Here, modified reaction time, thermal treatment, and pH conditions were controlled in the synthesis of NaYF<sub>4</sub>:Yb,Tm up-converted (UC) material to improve its photoluminescence properties. The best blue-emission performance was achieved for the UC3 sample prepared through 24 h-synthesis without thermal treatment at a pH of 5, which promotes the presence of the β-phase and smaller particle size. NaYF<sub>4</sub>:Yb,Tm has resulted in a highly efficient blue emitter material for light-driven drug release under near-IR wavelength. Thus, NaYF<sub>4</sub>:Yb,Tm up-converted material promotes the N-O bond cleavage of the oxime ester of Ciprofloxacin (prodrug) as a highly efficient photosensitized drug delivery process. HPLC chromatography and transient absorption spectroscopy measurements were performed to evaluate the drug release conversion rate. UC3 has resulted in a very stable and easily recovered material that can be used in several reaction cycles. This straightforward methodology can be extended to other drugs containing photoactive chromophores and is present as an alternative for drug release systems.https://www.mdpi.com/2227-9059/9/12/1953Up-Conversiondrug-deliveryNear IR-Light Therapy |
| spellingShingle | Edelweiss Moyano Rodríguez Miguel Gomez-Mendoza Raúl Pérez-Ruiz Beatriz Peñín Diego Sampedro Antonio Caamaño Víctor A. de la Peña O’Shea Controlled Synthesis of Up-Conversion NaYF<sub>4</sub>:Yb,Tm Nanoparticles for Drug Release under Near IR-Light Therapy Biomedicines Up-Conversion drug-delivery Near IR-Light Therapy |
| title | Controlled Synthesis of Up-Conversion NaYF<sub>4</sub>:Yb,Tm Nanoparticles for Drug Release under Near IR-Light Therapy |
| title_full | Controlled Synthesis of Up-Conversion NaYF<sub>4</sub>:Yb,Tm Nanoparticles for Drug Release under Near IR-Light Therapy |
| title_fullStr | Controlled Synthesis of Up-Conversion NaYF<sub>4</sub>:Yb,Tm Nanoparticles for Drug Release under Near IR-Light Therapy |
| title_full_unstemmed | Controlled Synthesis of Up-Conversion NaYF<sub>4</sub>:Yb,Tm Nanoparticles for Drug Release under Near IR-Light Therapy |
| title_short | Controlled Synthesis of Up-Conversion NaYF<sub>4</sub>:Yb,Tm Nanoparticles for Drug Release under Near IR-Light Therapy |
| title_sort | controlled synthesis of up conversion nayf sub 4 sub yb tm nanoparticles for drug release under near ir light therapy |
| topic | Up-Conversion drug-delivery Near IR-Light Therapy |
| url | https://www.mdpi.com/2227-9059/9/12/1953 |
| work_keys_str_mv | AT edelweissmoyanorodriguez controlledsynthesisofupconversionnayfsub4subybtmnanoparticlesfordrugreleaseundernearirlighttherapy AT miguelgomezmendoza controlledsynthesisofupconversionnayfsub4subybtmnanoparticlesfordrugreleaseundernearirlighttherapy AT raulperezruiz controlledsynthesisofupconversionnayfsub4subybtmnanoparticlesfordrugreleaseundernearirlighttherapy AT beatrizpenin controlledsynthesisofupconversionnayfsub4subybtmnanoparticlesfordrugreleaseundernearirlighttherapy AT diegosampedro controlledsynthesisofupconversionnayfsub4subybtmnanoparticlesfordrugreleaseundernearirlighttherapy AT antoniocaamano controlledsynthesisofupconversionnayfsub4subybtmnanoparticlesfordrugreleaseundernearirlighttherapy AT victoradelapenaoshea controlledsynthesisofupconversionnayfsub4subybtmnanoparticlesfordrugreleaseundernearirlighttherapy |