An 18-gene signature for vascular invasion is associated with aggressive features and reduced survival in breast cancer.
AIMS: Vascular invasion by tumor cells is known to be important for cancer progression. By microarray and qPCR analyses, we earlier identified an 18-gene signature associated with vascular involvement in endometrial cancer. Here, we explored the significance of this vascular invasion signature in mu...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2014-01-01
|
| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4048217?pdf=render |
| _version_ | 1818694932654718976 |
|---|---|
| author | Monica Mannelqvist Elisabeth Wik Ingunn M Stefansson Lars A Akslen |
| author_facet | Monica Mannelqvist Elisabeth Wik Ingunn M Stefansson Lars A Akslen |
| author_sort | Monica Mannelqvist |
| collection | DOAJ |
| description | AIMS: Vascular invasion by tumor cells is known to be important for cancer progression. By microarray and qPCR analyses, we earlier identified an 18-gene signature associated with vascular involvement in endometrial cancer. Here, we explored the significance of this vascular invasion signature in multiple series of breast cancer patients. METHODS AND RESULTS: The study includes 11 open access gene expression data sets which collectively provide information on 2423 breast cancer patients. The 18-gene signature showed consistent associations with aggressive features of breast cancer, like high tumor grade, hormone receptor negativity, HER2 positivity, a basal-like phenotype, reduced patient survival, and response to neoadjuvant chemotherapy. Also, the vascular invasion signature was associated with several other gene expression profiles related to vascular biology and tumor progression, including the Oncotype DX breast cancer recurrence signature. CONCLUSIONS: The 18-gene vascular invasion signature showed strong and consistent associations with aggressive features of breast cancer and reduced survival. |
| first_indexed | 2024-12-17T13:37:26Z |
| format | Article |
| id | doaj.art-a92e9d8240644a5581bce2954267e0a6 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-17T13:37:26Z |
| publishDate | 2014-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-a92e9d8240644a5581bce2954267e0a62022-12-21T21:46:25ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-0196e9878710.1371/journal.pone.0098787An 18-gene signature for vascular invasion is associated with aggressive features and reduced survival in breast cancer.Monica MannelqvistElisabeth WikIngunn M StefanssonLars A AkslenAIMS: Vascular invasion by tumor cells is known to be important for cancer progression. By microarray and qPCR analyses, we earlier identified an 18-gene signature associated with vascular involvement in endometrial cancer. Here, we explored the significance of this vascular invasion signature in multiple series of breast cancer patients. METHODS AND RESULTS: The study includes 11 open access gene expression data sets which collectively provide information on 2423 breast cancer patients. The 18-gene signature showed consistent associations with aggressive features of breast cancer, like high tumor grade, hormone receptor negativity, HER2 positivity, a basal-like phenotype, reduced patient survival, and response to neoadjuvant chemotherapy. Also, the vascular invasion signature was associated with several other gene expression profiles related to vascular biology and tumor progression, including the Oncotype DX breast cancer recurrence signature. CONCLUSIONS: The 18-gene vascular invasion signature showed strong and consistent associations with aggressive features of breast cancer and reduced survival.http://europepmc.org/articles/PMC4048217?pdf=render |
| spellingShingle | Monica Mannelqvist Elisabeth Wik Ingunn M Stefansson Lars A Akslen An 18-gene signature for vascular invasion is associated with aggressive features and reduced survival in breast cancer. PLoS ONE |
| title | An 18-gene signature for vascular invasion is associated with aggressive features and reduced survival in breast cancer. |
| title_full | An 18-gene signature for vascular invasion is associated with aggressive features and reduced survival in breast cancer. |
| title_fullStr | An 18-gene signature for vascular invasion is associated with aggressive features and reduced survival in breast cancer. |
| title_full_unstemmed | An 18-gene signature for vascular invasion is associated with aggressive features and reduced survival in breast cancer. |
| title_short | An 18-gene signature for vascular invasion is associated with aggressive features and reduced survival in breast cancer. |
| title_sort | 18 gene signature for vascular invasion is associated with aggressive features and reduced survival in breast cancer |
| url | http://europepmc.org/articles/PMC4048217?pdf=render |
| work_keys_str_mv | AT monicamannelqvist an18genesignatureforvascularinvasionisassociatedwithaggressivefeaturesandreducedsurvivalinbreastcancer AT elisabethwik an18genesignatureforvascularinvasionisassociatedwithaggressivefeaturesandreducedsurvivalinbreastcancer AT ingunnmstefansson an18genesignatureforvascularinvasionisassociatedwithaggressivefeaturesandreducedsurvivalinbreastcancer AT larsaakslen an18genesignatureforvascularinvasionisassociatedwithaggressivefeaturesandreducedsurvivalinbreastcancer AT monicamannelqvist 18genesignatureforvascularinvasionisassociatedwithaggressivefeaturesandreducedsurvivalinbreastcancer AT elisabethwik 18genesignatureforvascularinvasionisassociatedwithaggressivefeaturesandreducedsurvivalinbreastcancer AT ingunnmstefansson 18genesignatureforvascularinvasionisassociatedwithaggressivefeaturesandreducedsurvivalinbreastcancer AT larsaakslen 18genesignatureforvascularinvasionisassociatedwithaggressivefeaturesandreducedsurvivalinbreastcancer |