Effectiveness and safety of the combination therapy of micro-needling and minoxidil in androgenetic alopecia of Indonesian men: a randomized controlled trial
Introduction: Androgenetic alopecia (AGA) is the most common type of hair loss. Treatment options are limited. Microneedling, a minimally invasive technique can enhance hair growth by releasing growth factors. However, standardized protocol regarding the frequency, depth and duration has not been a...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
PAGEPress Publications
2024-02-01
|
| Series: | Dermatology Reports |
| Subjects: | |
| Online Access: | https://www.pagepress.org/journals/index.php/dr/article/view/9945 |
| _version_ | 1827356907451449344 |
|---|---|
| author | Kara Adistri Sondang P. Sirait Rahadi Rihatmadja Lili Legiawati Wresti Indriatmi Siti R.F. Saldi |
| author_facet | Kara Adistri Sondang P. Sirait Rahadi Rihatmadja Lili Legiawati Wresti Indriatmi Siti R.F. Saldi |
| author_sort | Kara Adistri |
| collection | DOAJ |
| description |
Introduction: Androgenetic alopecia (AGA) is the most common type of hair loss. Treatment options are limited. Microneedling, a minimally invasive technique can enhance hair growth by releasing growth factors. However, standardized protocol regarding the frequency, depth and duration has not been available. This study aims to determine the effectiveness and safety of the combination therapy of microneedling and minoxidil in AGA. Methods: This study was a randomized controlled clinical trial conducted over 12 weeks. Intervention group: a combination therapy of 4-weekly microneedling and 5% minoxidil, and control group got topical 5% minoxidil alone. Hair density and diameter were assessed using FotoFinder® trichoscale every 4 weeks. Results: A total of 36 male participants, between 26-51 years old, with Hamilton-Norwood type III-VI AGA were included. At the end of study, a significant increase in hair density was observed in the intervention group compared to control (95.6 vs 52.4 hair/cm², p<0.001), as was in hair diameter (18 vs 6 μm, p=0.004). Side effects, included itching and transient erythema, were well tolerated. Conclusion: The combination of 4-weekly microneedling and topical 5% minoxidil is effective in increasing both hair density and hair diameter, and safe to use in AGA patients.
|
| first_indexed | 2024-03-08T05:17:19Z |
| format | Article |
| id | doaj.art-a92eade8d7ee4d1b91e9a8cf63f631e5 |
| institution | Directory Open Access Journal |
| issn | 2036-7392 2036-7406 |
| language | English |
| last_indexed | 2024-03-08T05:17:19Z |
| publishDate | 2024-02-01 |
| publisher | PAGEPress Publications |
| record_format | Article |
| series | Dermatology Reports |
| spelling | doaj.art-a92eade8d7ee4d1b91e9a8cf63f631e52024-02-06T19:00:20ZengPAGEPress PublicationsDermatology Reports2036-73922036-74062024-02-0110.4081/dr.2024.9945Effectiveness and safety of the combination therapy of micro-needling and minoxidil in androgenetic alopecia of Indonesian men: a randomized controlled trialKara Adistri0Sondang P. Sirait1Rahadi Rihatmadja2Lili Legiawati3Wresti Indriatmi4Siti R.F. Saldi5Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Jakarta; Dr. Cipto Mangunkusumo Hospital, JakartaDepartment of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Jakarta; Dr. Cipto Mangunkusumo Hospital, JakartaDepartment of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Jakarta; Dr. Cipto Mangunkusumo Hospital, JakartaDepartment of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Jakarta; Dr. Cipto Mangunkusumo Hospital, JakartaDepartment of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Jakarta; Dr. Cipto Mangunkusumo Hospital, JakartaDr. Cipto Mangunkusumo Hospital, Jakarta; Clinical Epidemiology and Evidence-Based Medicine Unit, Faculty of Medicine, Universitas Indonesia, Jakarta Introduction: Androgenetic alopecia (AGA) is the most common type of hair loss. Treatment options are limited. Microneedling, a minimally invasive technique can enhance hair growth by releasing growth factors. However, standardized protocol regarding the frequency, depth and duration has not been available. This study aims to determine the effectiveness and safety of the combination therapy of microneedling and minoxidil in AGA. Methods: This study was a randomized controlled clinical trial conducted over 12 weeks. Intervention group: a combination therapy of 4-weekly microneedling and 5% minoxidil, and control group got topical 5% minoxidil alone. Hair density and diameter were assessed using FotoFinder® trichoscale every 4 weeks. Results: A total of 36 male participants, between 26-51 years old, with Hamilton-Norwood type III-VI AGA were included. At the end of study, a significant increase in hair density was observed in the intervention group compared to control (95.6 vs 52.4 hair/cm², p<0.001), as was in hair diameter (18 vs 6 μm, p=0.004). Side effects, included itching and transient erythema, were well tolerated. Conclusion: The combination of 4-weekly microneedling and topical 5% minoxidil is effective in increasing both hair density and hair diameter, and safe to use in AGA patients. https://www.pagepress.org/journals/index.php/dr/article/view/9945Androgenetic alopeciamicro-needlingminoxidil |
| spellingShingle | Kara Adistri Sondang P. Sirait Rahadi Rihatmadja Lili Legiawati Wresti Indriatmi Siti R.F. Saldi Effectiveness and safety of the combination therapy of micro-needling and minoxidil in androgenetic alopecia of Indonesian men: a randomized controlled trial Dermatology Reports Androgenetic alopecia micro-needling minoxidil |
| title | Effectiveness and safety of the combination therapy of micro-needling and minoxidil in androgenetic alopecia of Indonesian men: a randomized controlled trial |
| title_full | Effectiveness and safety of the combination therapy of micro-needling and minoxidil in androgenetic alopecia of Indonesian men: a randomized controlled trial |
| title_fullStr | Effectiveness and safety of the combination therapy of micro-needling and minoxidil in androgenetic alopecia of Indonesian men: a randomized controlled trial |
| title_full_unstemmed | Effectiveness and safety of the combination therapy of micro-needling and minoxidil in androgenetic alopecia of Indonesian men: a randomized controlled trial |
| title_short | Effectiveness and safety of the combination therapy of micro-needling and minoxidil in androgenetic alopecia of Indonesian men: a randomized controlled trial |
| title_sort | effectiveness and safety of the combination therapy of micro needling and minoxidil in androgenetic alopecia of indonesian men a randomized controlled trial |
| topic | Androgenetic alopecia micro-needling minoxidil |
| url | https://www.pagepress.org/journals/index.php/dr/article/view/9945 |
| work_keys_str_mv | AT karaadistri effectivenessandsafetyofthecombinationtherapyofmicroneedlingandminoxidilinandrogeneticalopeciaofindonesianmenarandomizedcontrolledtrial AT sondangpsirait effectivenessandsafetyofthecombinationtherapyofmicroneedlingandminoxidilinandrogeneticalopeciaofindonesianmenarandomizedcontrolledtrial AT rahadirihatmadja effectivenessandsafetyofthecombinationtherapyofmicroneedlingandminoxidilinandrogeneticalopeciaofindonesianmenarandomizedcontrolledtrial AT lililegiawati effectivenessandsafetyofthecombinationtherapyofmicroneedlingandminoxidilinandrogeneticalopeciaofindonesianmenarandomizedcontrolledtrial AT wrestiindriatmi effectivenessandsafetyofthecombinationtherapyofmicroneedlingandminoxidilinandrogeneticalopeciaofindonesianmenarandomizedcontrolledtrial AT sitirfsaldi effectivenessandsafetyofthecombinationtherapyofmicroneedlingandminoxidilinandrogeneticalopeciaofindonesianmenarandomizedcontrolledtrial |