The chromatin remodelling factor Chd7 protects auditory neurons and sensory hair cells from stress-induced degeneration
To improve our understanding of the mechanisms that protect hair cells in the ear from stress-induced death, Ahmed et al delete the chromodomain helicase DNA-binding protein 7 (CHD7) in auditory neurons and hair cells in mice. They observe sensorineural hearing loss and demonstrate that CHD7 control...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-11-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-021-02788-6 |
| _version_ | 1818838175388270592 |
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| author | Mohi Ahmed Ruth Moon Ravindra Singh Prajapati Elysia James M. Albert Basson Andrea Streit |
| author_facet | Mohi Ahmed Ruth Moon Ravindra Singh Prajapati Elysia James M. Albert Basson Andrea Streit |
| author_sort | Mohi Ahmed |
| collection | DOAJ |
| description | To improve our understanding of the mechanisms that protect hair cells in the ear from stress-induced death, Ahmed et al delete the chromodomain helicase DNA-binding protein 7 (CHD7) in auditory neurons and hair cells in mice. They observe sensorineural hearing loss and demonstrate that CHD7 controls the expression of stress pathway components, which could help to explain how CHD7 haploinsufficiency causes changes in the ear associated with CHARGE syndrome. |
| first_indexed | 2024-12-19T03:34:13Z |
| format | Article |
| id | doaj.art-a92fb875cfc14184bbec21667fb5460f |
| institution | Directory Open Access Journal |
| issn | 2399-3642 |
| language | English |
| last_indexed | 2024-12-19T03:34:13Z |
| publishDate | 2021-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Communications Biology |
| spelling | doaj.art-a92fb875cfc14184bbec21667fb5460f2022-12-21T20:37:25ZengNature PortfolioCommunications Biology2399-36422021-11-014111010.1038/s42003-021-02788-6The chromatin remodelling factor Chd7 protects auditory neurons and sensory hair cells from stress-induced degenerationMohi Ahmed0Ruth Moon1Ravindra Singh Prajapati2Elysia James3M. Albert Basson4Andrea Streit5Centre for Craniofacial and Regenerative Biology, Floor 27 Tower Wing, Guy’s Hospital, King’s College LondonCentre for Craniofacial and Regenerative Biology, Floor 27 Tower Wing, Guy’s Hospital, King’s College LondonCentre for Craniofacial and Regenerative Biology, Floor 27 Tower Wing, Guy’s Hospital, King’s College LondonWolfson Centre for Age-Related Diseases, Institute of Psychiatry, Psychology and Neuroscience, King’s College LondonCentre for Craniofacial and Regenerative Biology, Floor 27 Tower Wing, Guy’s Hospital, King’s College LondonCentre for Craniofacial and Regenerative Biology, Floor 27 Tower Wing, Guy’s Hospital, King’s College LondonTo improve our understanding of the mechanisms that protect hair cells in the ear from stress-induced death, Ahmed et al delete the chromodomain helicase DNA-binding protein 7 (CHD7) in auditory neurons and hair cells in mice. They observe sensorineural hearing loss and demonstrate that CHD7 controls the expression of stress pathway components, which could help to explain how CHD7 haploinsufficiency causes changes in the ear associated with CHARGE syndrome.https://doi.org/10.1038/s42003-021-02788-6 |
| spellingShingle | Mohi Ahmed Ruth Moon Ravindra Singh Prajapati Elysia James M. Albert Basson Andrea Streit The chromatin remodelling factor Chd7 protects auditory neurons and sensory hair cells from stress-induced degeneration Communications Biology |
| title | The chromatin remodelling factor Chd7 protects auditory neurons and sensory hair cells from stress-induced degeneration |
| title_full | The chromatin remodelling factor Chd7 protects auditory neurons and sensory hair cells from stress-induced degeneration |
| title_fullStr | The chromatin remodelling factor Chd7 protects auditory neurons and sensory hair cells from stress-induced degeneration |
| title_full_unstemmed | The chromatin remodelling factor Chd7 protects auditory neurons and sensory hair cells from stress-induced degeneration |
| title_short | The chromatin remodelling factor Chd7 protects auditory neurons and sensory hair cells from stress-induced degeneration |
| title_sort | chromatin remodelling factor chd7 protects auditory neurons and sensory hair cells from stress induced degeneration |
| url | https://doi.org/10.1038/s42003-021-02788-6 |
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