Chitosan-sodium lauryl sulfate/Eudragit S100 beads loaded with 5-fluorouracil: Influence of solvent and duration of crosslinking the crosslinking on physicochemical properties
Chitosan beads loaded with 5-fluorouracil (5-FU) were prepared by ionotropic gelation using sodium lauryl sulfate (SLS) as a crosslinking agent in presences of Eudragit S100. The objective was to improve the loading and sustained release of 5-FU. The influence of the solvent system, counter ion conc...
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| Format: | Article |
| Language: | English |
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IOP Publishing
2020-01-01
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| Series: | Materials Research Express |
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| Online Access: | https://doi.org/10.1088/2053-1591/abc90f |
| _version_ | 1797746897270603776 |
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| author | Saravanan Muniyandy Lui Mei Yi Aruna Santhagunam Lay Hong Chuah |
| author_facet | Saravanan Muniyandy Lui Mei Yi Aruna Santhagunam Lay Hong Chuah |
| author_sort | Saravanan Muniyandy |
| collection | DOAJ |
| description | Chitosan beads loaded with 5-fluorouracil (5-FU) were prepared by ionotropic gelation using sodium lauryl sulfate (SLS) as a crosslinking agent in presences of Eudragit S100. The objective was to improve the loading and sustained release of 5-FU. The influence of the solvent system, counter ion concentration, crosslinking time, and addition of Eudragit on particle size, drug loading, entrapment efficiency (E.E.), and in vitro release was investigated. The beads were also characterized by scanning electron microscopy, Fourier transform infrared (FTIR), and thermogravimetric analysis (TGA). Spherical beads were produced with at least 2% SLS, and the resultant particle size was smaller with higher SLS concentration. FTIR has confirmed the incorporation of 5-FU and the electrostatic interaction involved in the formation of chitosan/SLS/Eudragit beads. TGA graph has shown a sharp weight loss between 225 °C and 250 °C in beads prepared with an alcoholic crosslinking solution. The amorphous nature of the entrapped drug was also revealed in the TGA. All batches exhibited 5-FU burst release within 30 min, and beads prepared with 2% SLS/Eudragit has displayed a sustained release up to 4 h in a dissolution medium of increasing pH. Further, the E.E. of 5-FU was increased with hydroalcoholic solvent, lower SLS concentration, and shorter crosslinking time. |
| first_indexed | 2024-03-12T15:43:22Z |
| format | Article |
| id | doaj.art-a930b4ae56924e52a286c5899cbc60e3 |
| institution | Directory Open Access Journal |
| issn | 2053-1591 |
| language | English |
| last_indexed | 2024-03-12T15:43:22Z |
| publishDate | 2020-01-01 |
| publisher | IOP Publishing |
| record_format | Article |
| series | Materials Research Express |
| spelling | doaj.art-a930b4ae56924e52a286c5899cbc60e32023-08-09T15:52:36ZengIOP PublishingMaterials Research Express2053-15912020-01-0171111540210.1088/2053-1591/abc90fChitosan-sodium lauryl sulfate/Eudragit S100 beads loaded with 5-fluorouracil: Influence of solvent and duration of crosslinking the crosslinking on physicochemical propertiesSaravanan Muniyandy0https://orcid.org/0000-0002-6295-5676Lui Mei Yi1Aruna Santhagunam2Lay Hong Chuah3Department of Pharmacy, Fatima College of Health Sciences, PO Box 24162 Al Maqam, Al Ain, United Arab EmiratesSchool of Pharmacy, Monash University Malaysia , Jalan Lagoon Selatan, 46150 Bandar Sunway, Selangor Darul Ehsan, MalaysiaCentre of Nanotechnology, Indian Institute of Technology , Roorkee, Uttarakhand 247667, IndiaSchool of Pharmacy, Monash University Malaysia , Jalan Lagoon Selatan, 46150 Bandar Sunway, Selangor Darul Ehsan, MalaysiaChitosan beads loaded with 5-fluorouracil (5-FU) were prepared by ionotropic gelation using sodium lauryl sulfate (SLS) as a crosslinking agent in presences of Eudragit S100. The objective was to improve the loading and sustained release of 5-FU. The influence of the solvent system, counter ion concentration, crosslinking time, and addition of Eudragit on particle size, drug loading, entrapment efficiency (E.E.), and in vitro release was investigated. The beads were also characterized by scanning electron microscopy, Fourier transform infrared (FTIR), and thermogravimetric analysis (TGA). Spherical beads were produced with at least 2% SLS, and the resultant particle size was smaller with higher SLS concentration. FTIR has confirmed the incorporation of 5-FU and the electrostatic interaction involved in the formation of chitosan/SLS/Eudragit beads. TGA graph has shown a sharp weight loss between 225 °C and 250 °C in beads prepared with an alcoholic crosslinking solution. The amorphous nature of the entrapped drug was also revealed in the TGA. All batches exhibited 5-FU burst release within 30 min, and beads prepared with 2% SLS/Eudragit has displayed a sustained release up to 4 h in a dissolution medium of increasing pH. Further, the E.E. of 5-FU was increased with hydroalcoholic solvent, lower SLS concentration, and shorter crosslinking time.https://doi.org/10.1088/2053-1591/abc90fChitosansodium lauryl sulfateEudragit S1005-fluorouracilionotropic gelationdrug loading |
| spellingShingle | Saravanan Muniyandy Lui Mei Yi Aruna Santhagunam Lay Hong Chuah Chitosan-sodium lauryl sulfate/Eudragit S100 beads loaded with 5-fluorouracil: Influence of solvent and duration of crosslinking the crosslinking on physicochemical properties Materials Research Express Chitosan sodium lauryl sulfate Eudragit S100 5-fluorouracil ionotropic gelation drug loading |
| title | Chitosan-sodium lauryl sulfate/Eudragit S100 beads loaded with 5-fluorouracil: Influence of solvent and duration of crosslinking the crosslinking on physicochemical properties |
| title_full | Chitosan-sodium lauryl sulfate/Eudragit S100 beads loaded with 5-fluorouracil: Influence of solvent and duration of crosslinking the crosslinking on physicochemical properties |
| title_fullStr | Chitosan-sodium lauryl sulfate/Eudragit S100 beads loaded with 5-fluorouracil: Influence of solvent and duration of crosslinking the crosslinking on physicochemical properties |
| title_full_unstemmed | Chitosan-sodium lauryl sulfate/Eudragit S100 beads loaded with 5-fluorouracil: Influence of solvent and duration of crosslinking the crosslinking on physicochemical properties |
| title_short | Chitosan-sodium lauryl sulfate/Eudragit S100 beads loaded with 5-fluorouracil: Influence of solvent and duration of crosslinking the crosslinking on physicochemical properties |
| title_sort | chitosan sodium lauryl sulfate eudragit s100 beads loaded with 5 fluorouracil influence of solvent and duration of crosslinking the crosslinking on physicochemical properties |
| topic | Chitosan sodium lauryl sulfate Eudragit S100 5-fluorouracil ionotropic gelation drug loading |
| url | https://doi.org/10.1088/2053-1591/abc90f |
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