Molecular Abnormalities in BTBR Mice and Their Relevance to Schizophrenia and Autism Spectrum Disorders: An Overview of Transcriptomic and Proteomic Studies

Molecular Abnormalities in BTBR Mice and Their Relevance to Schizophrenia and Autism Spectrum Disorders: An Overview of Transcriptomic and Proteomic Studies

Animal models of psychopathologies are of exceptional interest for neurobiologists because these models allow us to clarify molecular mechanisms underlying the pathologies. One such model is the inbred BTBR strain of mice, which is characterized by behavioral, neuroanatomical, and physiological hall...

Full description

Bibliographic Details
Main Authors:	Polina Kisaretova, Anton Tsybko, Natalia Bondar, Vasiliy Reshetnikov
Format:	Article
Language:	English
Published:	MDPI AG 2023-01-01
Series:	Biomedicines
Subjects:	BTBR transcriptome proteome cortex hippocampus ASD
Online Access:	https://www.mdpi.com/2227-9059/11/2/289

Similar Items

Human amniotic epithelial cell transplantation promotes neurogenesis and ameliorates social deficits in BTBR mice
by: Ruiyu Zhang, et al.
Published: (2019-05-01)

Unique Features of the Immune Response in BTBR Mice
by: Anastasia Mutovina, et al.
Published: (2022-12-01)

Comparative gene expression analysis of two mouse models of autism:transcriptome profiling of the BTBR and En2-/- hippocampus
by: Giovanni Provenzano, et al.
Published: (2016-08-01)

Hippocampal transcriptomic and proteomic alterations in the BTBR mouse model of autism spectrum disorder
by: Caitlin M Daimon, et al.
Published: (2015-11-01)

Seizure susceptibility to various convulsant stimuli in the BTBR mouse model of autism spectrum disorders
by: Martina Tallarico, et al.
Published: (2023-04-01)

GW4064 Alters Gut Microbiota Composition and Counteracts Autism-Associated Behaviors in BTBR T+tf/J Mice
by: Jiayin Liu, et al.
Published: (2022-06-01)

Neuronal correlates of asocial behavior in a BTBR T+Itpr3tf/J mouse model of autism
by: Ksenia Zuzanna Meyza, et al.
Published: (2015-08-01)

Altered meningeal immunity contributing to the autism-like behavior of BTBR T+ Itpr3tf/J mice
by: Mohammad Nizam Uddin, et al.
Published: (2022-12-01)

Brain-Derived Neurotrophic Factor (BDNF) in Mechanisms of Autistic-like Behavior in BTBR Mice: Crosstalk with the Dopaminergic Brain System
by: Tatiana Ilchibaeva, et al.
Published: (2023-05-01)

Metformin Administration During Early Postnatal Life Rescues Autistic-Like Behaviors in the BTBR T+ Itpr3tf/J Mouse Model of Autism
by: Lian Wang, et al.
Published: (2018-11-01)

Prebiotic, Probiotic, and Synbiotic Consumption Alter Behavioral Variables and Intestinal Permeability and Microbiota in BTBR Mice
by: Jodi E. Nettleton, et al.
Published: (2021-08-01)

Behavioral, Anti-Inflammatory, and Neuroprotective Effects of a Novel FPR2 Agonist in Two Mouse Models of Autism
by: Claudia Cristiano, et al.
Published: (2022-01-01)

5-Aminoisoquinolinone, a PARP-1 Inhibitor, Ameliorates Immune Abnormalities through Upregulation of Anti-Inflammatory and Downregulation of Inflammatory Parameters in T Cells of BTBR Mouse Model of Autism
by: Khaled Alhosaini, et al.
Published: (2021-02-01)

The Exposure to Lead (Pb) Exacerbates Immunological Abnormalities in BTBR T<sup>+</sup> Itpr<sup>3tf</sup>/J Mice through the Regulation of Signaling Pathways Relevant to T Cells
by: Mohammed A. Assiri, et al.
Published: (2023-11-01)

General Anesthesia During Neurodevelopment Reduces Autistic Behavior in Adult BTBR Mice, a Murine Model of Autism
by: Jianchen Cui, et al.
Published: (2021-11-01)

Transcriptome Alterations Caused by Social Defeat Stress of Various Durations in Mice and Its Relevance to Depression and Posttraumatic Stress Disorder in Humans: A Meta-Analysis
by: Vasiliy V. Reshetnikov, et al.
Published: (2022-11-01)

Cadmium Exposure Is Associated with Behavioral Deficits and Neuroimmune Dysfunction in BTBR T<sup>+</sup> Itpr3tf/J Mice
by: Mohammed M. Alanazi, et al.
Published: (2023-03-01)

Enhancement of Short-Term Memory by Methyl-6-(Phenylethynyl)-Pyridine in the BTBR T+tf/J Mouse Model of Autism Spectrum Disorder
by: Haijie Yang, et al.
Published: (2015-03-01)

Maturation of nucleus accumbens synaptic transmission signals a critical period for the rescue of social deficits in a mouse model of autism spectrum disorder
by: Melina Matthiesen, et al.
Published: (2023-05-01)

Meta-Inflammation and De Novo Lipogenesis Markers Are Involved in Metabolic Associated Fatty Liver Disease Progression in BTBR ob/ob Mice
by: Lucas Opazo-Ríos, et al.
Published: (2022-04-01)

Simultaneous Blockade of Histamine H<sub>3</sub> Receptors and Inhibition of Acetylcholine Esterase Alleviate Autistic-Like Behaviors in BTBR T+ tf/J Mouse Model of Autism
by: Nermin Eissa, et al.
Published: (2020-08-01)

Blood Proteomics Analysis Reveals Potential Biomarkers and Convergent Dysregulated Pathways in Autism Spectrum Disorder: A Pilot Study
by: Areej Mesleh, et al.
Published: (2023-04-01)

Proteomic Analysis of Brain Region and Sex-Specific Synaptic Protein Expression in the Adult Mouse Brain
by: Ute Distler, et al.
Published: (2020-01-01)

Alterations of the Hippocampal Networks in Valproic Acid-Induced Rat Autism Model
by: Veronika Bódi, et al.
Published: (2022-02-01)

Association Among Gut Microbes, Intestinal Physiology, and Autism
by: Wei-Li Wu
Published: (2017-11-01)

Altered dopaminergic pathways and therapeutic effects of intranasal dopamine in two distinct mouse models of autism
by: Owen Y. Chao, et al.
Published: (2020-08-01)

P-cresol Alters Brain Dopamine Metabolism and Exacerbates Autism-Like Behaviors in the BTBR Mouse
by: Tiziana Pascucci, et al.
Published: (2020-04-01)

Entorhinal cortex volume in antipsychotic-naïve schizophrenia
by: Sam P Jose, et al.
Published: (2012-01-01)

Aflatoxin B<sub>1</sub> Exposure Aggravates Neurobehavioral Deficits and Immune Dysfunctions of Th1, Th9, Th17, Th22, and T Regulatory Cell-Related Transcription Factor Signaling in the BTBR T<sup>+</sup>Itpr3<sup>tf</sup>/J Mouse Model of Autism
by: Mohammad Y. Alwetaid, et al.
Published: (2023-10-01)

Metformin treatment during neonatal period rescues hippocampal neurogenesis in the BTBR T+Itpr3tf/J mouse model of autism
by: ZHONG Hongyu, et al.
Published: (2020-01-01)

Chaihu Oral Liquid improves hippocampal neurogenesis and short-term memory defects in adult BTBR autism mice
by: CHEN Mei, et al.
Published: (2022-05-01)

Proteomic-Based Approach Reveals the Involvement of Apolipoprotein A-I in Related Phenotypes of Autism Spectrum Disorder in the BTBR Mouse Model
by: Qi Li, et al.
Published: (2022-12-01)

Insights into the structure and function of the hippocampus: implications for the pathophysiology and treatment of autism spectrum disorder
by: Junzi Long, et al.
Published: (2024-04-01)

Imaging Violence in Schizophrenia: A Systematic Review and Critical Discussion of the MRI Literature
by: Maria Fjellvang, et al.
Published: (2018-07-01)

Microbiota-related Changes in Bile Acid & Tryptophan Metabolism are Associated with Gastrointestinal Dysfunction in a Mouse Model of Autism
by: Anna V. Golubeva, et al.
Published: (2017-10-01)

Preliminary evaluation of the proteomic profiling in the hippocampus of aged grazing cattle
by: Flora Cozzolino, et al.
Published: (2023-10-01)

A Global Multiregional Proteomic Map of the Human Cerebral Cortex
by: Zhengguang Guo, et al.
Published: (2022-08-01)

Disorganization of Oscillatory Activity in Animal Models of Schizophrenia
by: Lucinda J. Speers, et al.
Published: (2021-10-01)

iTRAQ and PRM-Based Comparative Proteomic Profiling of the Hippocampus in Rat Models of Epilepsy
by: Congcong Zhao, et al.
Published: (2023-01-01)

Abnormal visuomotor processing in schizophrenia
by: Siân E. Robson, et al.
Published: (2016-01-01)