Visualizing the Potential Impairment of Polymyxin B to Central Nervous System Through MR Susceptibility-Weighted Imaging

Visualizing the Potential Impairment of Polymyxin B to Central Nervous System Through MR Susceptibility-Weighted Imaging

Polymyxin B (PMB) exert bactericidal effects on the cell wall of Gram-negative bacteria, leading to changes in the permeability of the cytoplasmic membrane and resulting in cell death, which is sensitive to the multi-resistant Gram-negative bacteria. However, the severe toxicity and adverse side eff...

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Bibliographic Details
Main Authors: Ni Zhang, Lichong Zhu, Qiuhong Ouyang, Saisai Yue, Yichun Huang, Shuang Qu, Runwei Li, Yuanyuan Qiao, Man Xu, Fangfei He, Bin Zhao, Lai Wei, Xiaoai Wu, Peisen Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-12-01
Series:Frontiers in Pharmacology
Subjects:
polymyxin B
neurotoxicity
Fe3O4 nanoparticles
in vivo
susceptibility-weighted imaging
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.784864/full

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