Evidence that the density of self peptide-MHC ligands regulates T-cell receptor signaling.

Evidence that the density of self peptide-MHC ligands regulates T-cell receptor signaling.

Noncognate or self peptide-MHC (pMHC) ligands productively interact with T-cell receptor (TCR) and are always in a large access over the cognate pMHC on the surface of antigen presenting cells. We assembled soluble cognate and noncognate pMHC class I (pMHC-I) ligands at designated ratios on various...

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Bibliographic Details
Main Authors:	Nadia Anikeeva, Dimitry Gakamsky, Jørgen Schøller, Yuri Sykulev
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2012-01-01
Series:	PLoS ONE
Online Access:	http://europepmc.org/articles/PMC3411518?pdf=render

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