The Regenerative Power of Stem Cells: Treating Bleomycin-Induced Lung Fibrosis
Amrita Vats,1 Pankaj Chaturvedi2 1Department of Pharmacology and Regenerative Medicine, University of Illinois, Chicago, IL, 60612, USA; 2Department of Cell and Developmental Biology, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USACorrespondence: Pankaj Chaturvedi, Email pankajch@...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2023-09-01
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| Series: | Stem Cells and Cloning: Advances and Applications |
| Subjects: | |
| Online Access: | https://www.dovepress.com/the-regenerative-power-of-stem-cells-treating-bleomycin-induced-lung-f-peer-reviewed-fulltext-article-SCCAA |
| _version_ | 1827818262120890368 |
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| author | Vats A Chaturvedi P |
| author_facet | Vats A Chaturvedi P |
| author_sort | Vats A |
| collection | DOAJ |
| description | Amrita Vats,1 Pankaj Chaturvedi2 1Department of Pharmacology and Regenerative Medicine, University of Illinois, Chicago, IL, 60612, USA; 2Department of Cell and Developmental Biology, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USACorrespondence: Pankaj Chaturvedi, Email pankajch@illinois.eduAbstract: Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive lung disease with no known cure, characterized by the formation of scar tissue in the lungs, leading to respiratory failure. Although the exact cause of IPF remains unclear, the condition is thought to result from a combination of genetic and environmental factors. One of the most widely used animal models to study IPF is the bleomycin-induced lung injury model in mice. In this model, the administration of the chemotherapeutic agent bleomycin causes pulmonary inflammation and fibrosis, which closely mimics the pathological features of human IPF. Numerous recent investigations have explored the functions of various categories of stem cells in the healing process of lung injury induced by bleomycin in mice, documenting the beneficial effects and challenges of this approach. Differentiation of stem cells into various cell types and their ability to modulate tissue microenvironment is an emerging aspect of the regenerative therapies. This review article aims to provide a comprehensive overview of the role of stem cells in repairing bleomycin-induced lung injury. It delves into the mechanisms through which various types of stem cells, including mesenchymal stem cells, embryonic stem cells, induced pluripotent stem cells, and lung resident stem cells, exert their therapeutic effects in this specific model. We have also discussed the unique set of intermediate markers and signaling factors that can influence the proliferation and differentiation of alveolar epithelial cells both during lung repair and homeostasis. Finally, we highlight the challenges and opportunities associated with translating stem cell therapy to the clinic for IPF patients. The novelty and implications of this review extend beyond the understanding of the potential of stem cells in treating IPF to the broader field of regenerative medicine. We believe that the review paves the way for further advancements in stem cell therapies, offering hope for patients suffering from this debilitating and currently incurable disease.Keywords: pulmonary fibrosis, regeneration, differentiation, bleomycin, alveoli, proliferation |
| first_indexed | 2024-03-12T00:45:22Z |
| format | Article |
| id | doaj.art-a935393987844574a2059038442b8f83 |
| institution | Directory Open Access Journal |
| issn | 1178-6957 |
| language | English |
| last_indexed | 2024-03-12T00:45:22Z |
| publishDate | 2023-09-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Stem Cells and Cloning: Advances and Applications |
| spelling | doaj.art-a935393987844574a2059038442b8f832023-09-14T19:09:03ZengDove Medical PressStem Cells and Cloning: Advances and Applications1178-69572023-09-01Volume 16435986630The Regenerative Power of Stem Cells: Treating Bleomycin-Induced Lung FibrosisVats AChaturvedi PAmrita Vats,1 Pankaj Chaturvedi2 1Department of Pharmacology and Regenerative Medicine, University of Illinois, Chicago, IL, 60612, USA; 2Department of Cell and Developmental Biology, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USACorrespondence: Pankaj Chaturvedi, Email pankajch@illinois.eduAbstract: Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive lung disease with no known cure, characterized by the formation of scar tissue in the lungs, leading to respiratory failure. Although the exact cause of IPF remains unclear, the condition is thought to result from a combination of genetic and environmental factors. One of the most widely used animal models to study IPF is the bleomycin-induced lung injury model in mice. In this model, the administration of the chemotherapeutic agent bleomycin causes pulmonary inflammation and fibrosis, which closely mimics the pathological features of human IPF. Numerous recent investigations have explored the functions of various categories of stem cells in the healing process of lung injury induced by bleomycin in mice, documenting the beneficial effects and challenges of this approach. Differentiation of stem cells into various cell types and their ability to modulate tissue microenvironment is an emerging aspect of the regenerative therapies. This review article aims to provide a comprehensive overview of the role of stem cells in repairing bleomycin-induced lung injury. It delves into the mechanisms through which various types of stem cells, including mesenchymal stem cells, embryonic stem cells, induced pluripotent stem cells, and lung resident stem cells, exert their therapeutic effects in this specific model. We have also discussed the unique set of intermediate markers and signaling factors that can influence the proliferation and differentiation of alveolar epithelial cells both during lung repair and homeostasis. Finally, we highlight the challenges and opportunities associated with translating stem cell therapy to the clinic for IPF patients. The novelty and implications of this review extend beyond the understanding of the potential of stem cells in treating IPF to the broader field of regenerative medicine. We believe that the review paves the way for further advancements in stem cell therapies, offering hope for patients suffering from this debilitating and currently incurable disease.Keywords: pulmonary fibrosis, regeneration, differentiation, bleomycin, alveoli, proliferationhttps://www.dovepress.com/the-regenerative-power-of-stem-cells-treating-bleomycin-induced-lung-f-peer-reviewed-fulltext-article-SCCAApulmonary fibrosisregenerationdifferentiationbleomycinalveoliproliferation |
| spellingShingle | Vats A Chaturvedi P The Regenerative Power of Stem Cells: Treating Bleomycin-Induced Lung Fibrosis Stem Cells and Cloning: Advances and Applications pulmonary fibrosis regeneration differentiation bleomycin alveoli proliferation |
| title | The Regenerative Power of Stem Cells: Treating Bleomycin-Induced Lung Fibrosis |
| title_full | The Regenerative Power of Stem Cells: Treating Bleomycin-Induced Lung Fibrosis |
| title_fullStr | The Regenerative Power of Stem Cells: Treating Bleomycin-Induced Lung Fibrosis |
| title_full_unstemmed | The Regenerative Power of Stem Cells: Treating Bleomycin-Induced Lung Fibrosis |
| title_short | The Regenerative Power of Stem Cells: Treating Bleomycin-Induced Lung Fibrosis |
| title_sort | regenerative power of stem cells treating bleomycin induced lung fibrosis |
| topic | pulmonary fibrosis regeneration differentiation bleomycin alveoli proliferation |
| url | https://www.dovepress.com/the-regenerative-power-of-stem-cells-treating-bleomycin-induced-lung-f-peer-reviewed-fulltext-article-SCCAA |
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