Rs7903146 variant of TCF7L2 gene and rs18012824 variant of PPARG2 gene (Pro12Ala) are associated with type 2 diabetes mellitus in Novosibirsk population
Aim. To investigate the association of polymorphisms in TCF7L2 and PPARG2 genes with type 2 diabetes mellitus (T2DM) in Novosibirsk population. Materials and Methods. We examined 391 patients with T2DM and 556 individuals with normal glucose metabolism. Allelic identification was performed with T...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Endocrinology Research Centre
2013-12-01
|
| Series: | Сахарный диабет |
| Subjects: | |
| Online Access: | https://www.dia-endojournals.ru/jour/article/view/3846 |
| _version_ | 1797255230864228352 |
|---|---|
| author | Irina Arkad'evna Bondar' Maksim Leonidovich Filipenko Olesya Yur'evna Shabel'nikova Ekaterina Alexandrovna Sokolova |
| author_facet | Irina Arkad'evna Bondar' Maksim Leonidovich Filipenko Olesya Yur'evna Shabel'nikova Ekaterina Alexandrovna Sokolova |
| author_sort | Irina Arkad'evna Bondar' |
| collection | DOAJ |
| description | Aim. To investigate the association of polymorphisms in TCF7L2 and PPARG2 genes with type 2 diabetes mellitus (T2DM) in Novosibirsk population. Materials and Methods. We examined 391 patients with T2DM and 556 individuals with normal glucose metabolism. Allelic identification was performed with TaqMan technique, implementing allele-specific real-time PCR. Results. Analysis shows that allelic frequency distribution of rs1801282 variant of PPARG2 gene and rs7903146 variant of TCF7L2 differs significantly between the study and control groups (OR [CI 95%]=1.44 [1.12?1.85], p=0.005 and OR [CI 95%]=1.57 [1.17?2.10], p=0.003, respectively). T2DM patients with T/T genotype of rs7903146 variant of TCF7L2 gene had lower BMI (p=0.02). Observed combination of risk alleles reached 99%. Combined beta-cell dysfunction and insulin resistance genotypes were identified in 56% of tested subjects, isolated insulin resistance ? in 42.2% of subjects, and isolated beta-cell dysfunction ? in 0.8% of subjects. Conclusion. Our data shows that carrier state of 12Pro rs1801284 variant of PPARG2 gene and T-allele rs7903146 variant of TCF7L2 gene are associated with T2DM in Novosibirsk population, increasing its risk 1.44 and 1.57 times, respectively. Combination of these polymorphisms was observed in 99% of patients with T2DM. |
| first_indexed | 2024-03-08T15:21:36Z |
| format | Article |
| id | doaj.art-a93672b587254939ad789a2ac072e8ed |
| institution | Directory Open Access Journal |
| issn | 2072-0351 2072-0378 |
| language | English |
| last_indexed | 2024-04-24T22:02:33Z |
| publishDate | 2013-12-01 |
| publisher | Endocrinology Research Centre |
| record_format | Article |
| series | Сахарный диабет |
| spelling | doaj.art-a93672b587254939ad789a2ac072e8ed2024-03-20T11:47:58ZengEndocrinology Research CentreСахарный диабет2072-03512072-03782013-12-01164172210.14341/DM2013417-223819Rs7903146 variant of TCF7L2 gene and rs18012824 variant of PPARG2 gene (Pro12Ala) are associated with type 2 diabetes mellitus in Novosibirsk populationIrina Arkad'evna Bondar'0Maksim Leonidovich Filipenko1Olesya Yur'evna Shabel'nikova2Ekaterina Alexandrovna Sokolova3Novosibirsk State Medical University, NovosibirskInstitute of Chemical Biology and Fundamental Medicine, NovosibirskNovosibirsk State Regional Hospital, NovosibirskInstitute of Chemical Biology and Fundamental Medicine, NovosibirskAim. To investigate the association of polymorphisms in TCF7L2 and PPARG2 genes with type 2 diabetes mellitus (T2DM) in Novosibirsk population. Materials and Methods. We examined 391 patients with T2DM and 556 individuals with normal glucose metabolism. Allelic identification was performed with TaqMan technique, implementing allele-specific real-time PCR. Results. Analysis shows that allelic frequency distribution of rs1801282 variant of PPARG2 gene and rs7903146 variant of TCF7L2 differs significantly between the study and control groups (OR [CI 95%]=1.44 [1.12?1.85], p=0.005 and OR [CI 95%]=1.57 [1.17?2.10], p=0.003, respectively). T2DM patients with T/T genotype of rs7903146 variant of TCF7L2 gene had lower BMI (p=0.02). Observed combination of risk alleles reached 99%. Combined beta-cell dysfunction and insulin resistance genotypes were identified in 56% of tested subjects, isolated insulin resistance ? in 42.2% of subjects, and isolated beta-cell dysfunction ? in 0.8% of subjects. Conclusion. Our data shows that carrier state of 12Pro rs1801284 variant of PPARG2 gene and T-allele rs7903146 variant of TCF7L2 gene are associated with T2DM in Novosibirsk population, increasing its risk 1.44 and 1.57 times, respectively. Combination of these polymorphisms was observed in 99% of patients with T2DM.https://www.dia-endojournals.ru/jour/article/view/3846type 2 diabetes mellitusgeneticsbeta-cell dysfunctioninsulin resistancepparg2tcf7l2 |
| spellingShingle | Irina Arkad'evna Bondar' Maksim Leonidovich Filipenko Olesya Yur'evna Shabel'nikova Ekaterina Alexandrovna Sokolova Rs7903146 variant of TCF7L2 gene and rs18012824 variant of PPARG2 gene (Pro12Ala) are associated with type 2 diabetes mellitus in Novosibirsk population Сахарный диабет type 2 diabetes mellitus genetics beta-cell dysfunction insulin resistance pparg2 tcf7l2 |
| title | Rs7903146 variant of TCF7L2 gene and rs18012824 variant of PPARG2 gene (Pro12Ala) are associated with type 2 diabetes mellitus in Novosibirsk population |
| title_full | Rs7903146 variant of TCF7L2 gene and rs18012824 variant of PPARG2 gene (Pro12Ala) are associated with type 2 diabetes mellitus in Novosibirsk population |
| title_fullStr | Rs7903146 variant of TCF7L2 gene and rs18012824 variant of PPARG2 gene (Pro12Ala) are associated with type 2 diabetes mellitus in Novosibirsk population |
| title_full_unstemmed | Rs7903146 variant of TCF7L2 gene and rs18012824 variant of PPARG2 gene (Pro12Ala) are associated with type 2 diabetes mellitus in Novosibirsk population |
| title_short | Rs7903146 variant of TCF7L2 gene and rs18012824 variant of PPARG2 gene (Pro12Ala) are associated with type 2 diabetes mellitus in Novosibirsk population |
| title_sort | rs7903146 variant of tcf7l2 gene and rs18012824 variant of pparg2 gene pro12ala are associated with type 2 diabetes mellitus in novosibirsk population |
| topic | type 2 diabetes mellitus genetics beta-cell dysfunction insulin resistance pparg2 tcf7l2 |
| url | https://www.dia-endojournals.ru/jour/article/view/3846 |
| work_keys_str_mv | AT irinaarkadevnabondar rs7903146variantoftcf7l2geneandrs18012824variantofpparg2genepro12alaareassociatedwithtype2diabetesmellitusinnovosibirskpopulation AT maksimleonidovichfilipenko rs7903146variantoftcf7l2geneandrs18012824variantofpparg2genepro12alaareassociatedwithtype2diabetesmellitusinnovosibirskpopulation AT olesyayurevnashabelnikova rs7903146variantoftcf7l2geneandrs18012824variantofpparg2genepro12alaareassociatedwithtype2diabetesmellitusinnovosibirskpopulation AT ekaterinaalexandrovnasokolova rs7903146variantoftcf7l2geneandrs18012824variantofpparg2genepro12alaareassociatedwithtype2diabetesmellitusinnovosibirskpopulation |