Recent advances in engineered polymeric materials for efficient photodynamic inactivation of bacterial pathogens
Nowadays, infectious diseases persist as a global crisis by causing significant destruction to public health and the economic stability of countries worldwide. Especially bacterial infections remain a most severe concern due to the prevalence and emergence of multi-drug resistance (MDR) and limitati...
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2023-03-01
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| Series: | Bioactive Materials |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2452199X22003486 |
| _version_ | 1827271183968501760 |
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| author | Sathishkumar Gnanasekar Gopinath Kasi Xiaodong He Kai Zhang Liqun Xu En-Tang Kang |
| author_facet | Sathishkumar Gnanasekar Gopinath Kasi Xiaodong He Kai Zhang Liqun Xu En-Tang Kang |
| author_sort | Sathishkumar Gnanasekar |
| collection | DOAJ |
| description | Nowadays, infectious diseases persist as a global crisis by causing significant destruction to public health and the economic stability of countries worldwide. Especially bacterial infections remain a most severe concern due to the prevalence and emergence of multi-drug resistance (MDR) and limitations with existing therapeutic options. Antibacterial photodynamic therapy (APDT) is a potential therapeutic modality that involves the systematic administration of photosensitizers (PSs), light, and molecular oxygen (O2) for coping with bacterial infections. Although the existing porphyrin and non-porphyrin PSs were effective in APDT, the poor solubility, limited efficacy against Gram-negative bacteria, and non-specific distribution hinder their clinical applications. Accordingly, to promote the efficiency of conventional PSs, various polymer-driven modification and functionalization strategies have been adopted to engineer multifunctional hybrid phototherapeutics. This review assesses recent advancements and state-of-the-art research in polymer-PSs hybrid materials developed for APDT applications. Further, the key research findings of the following aspects are considered in-depth with constructive discussions: i) PSs-integrated/functionalized polymeric composites through various molecular interactions; ii) PSs-deposited coatings on different substrates and devices to eliminate healthcare-associated infections; and iii) PSs-embedded films, scaffolds, and hydrogels for regenerative medicine applications. |
| first_indexed | 2024-04-11T22:26:44Z |
| format | Article |
| id | doaj.art-a936f7de12d947479d0ae3262d8427d1 |
| institution | Directory Open Access Journal |
| issn | 2452-199X |
| language | English |
| last_indexed | 2025-03-22T05:33:17Z |
| publishDate | 2023-03-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Bioactive Materials |
| spelling | doaj.art-a936f7de12d947479d0ae3262d8427d12024-04-26T20:45:09ZengKeAi Communications Co., Ltd.Bioactive Materials2452-199X2023-03-0121157174Recent advances in engineered polymeric materials for efficient photodynamic inactivation of bacterial pathogensSathishkumar Gnanasekar0Gopinath Kasi1Xiaodong He2Kai Zhang3Liqun Xu4En-Tang Kang5Chongqing Key Laboratory for Advanced Materials and Technologies of Clean Energies, School of Materials and Energy, Southwest University, Chongqing, 400715, PR ChinaChongqing Key Laboratory for Advanced Materials and Technologies of Clean Energies, School of Materials and Energy, Southwest University, Chongqing, 400715, PR ChinaChongqing Key Laboratory for Advanced Materials and Technologies of Clean Energies, School of Materials and Energy, Southwest University, Chongqing, 400715, PR ChinaChongqing Key Laboratory for Advanced Materials and Technologies of Clean Energies, School of Materials and Energy, Southwest University, Chongqing, 400715, PR ChinaChongqing Key Laboratory for Advanced Materials and Technologies of Clean Energies, School of Materials and Energy, Southwest University, Chongqing, 400715, PR China; Key Laboratory of Laser Technology and Optoelectronic Functional Materials of Hainan Province, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou, 571158, PR China; Corresponding author. Chongqing Key Laboratory for Advanced Materials and Technologies of Clean Energies, School of Materials and Energy, Southwest University, Chongqing, 400715, PR China.Chongqing Key Laboratory for Advanced Materials and Technologies of Clean Energies, School of Materials and Energy, Southwest University, Chongqing, 400715, PR China; Department of Chemical and Biomolecular Engineering, National University of Singapore, Kent Ridge, 117576, Singapore; Corresponding author. Chongqing Key Laboratory for Advanced Materials and Technologies of Clean Energies, School of Materials and Energy, Southwest University, Chongqing, 400715, PR China.Nowadays, infectious diseases persist as a global crisis by causing significant destruction to public health and the economic stability of countries worldwide. Especially bacterial infections remain a most severe concern due to the prevalence and emergence of multi-drug resistance (MDR) and limitations with existing therapeutic options. Antibacterial photodynamic therapy (APDT) is a potential therapeutic modality that involves the systematic administration of photosensitizers (PSs), light, and molecular oxygen (O2) for coping with bacterial infections. Although the existing porphyrin and non-porphyrin PSs were effective in APDT, the poor solubility, limited efficacy against Gram-negative bacteria, and non-specific distribution hinder their clinical applications. Accordingly, to promote the efficiency of conventional PSs, various polymer-driven modification and functionalization strategies have been adopted to engineer multifunctional hybrid phototherapeutics. This review assesses recent advancements and state-of-the-art research in polymer-PSs hybrid materials developed for APDT applications. Further, the key research findings of the following aspects are considered in-depth with constructive discussions: i) PSs-integrated/functionalized polymeric composites through various molecular interactions; ii) PSs-deposited coatings on different substrates and devices to eliminate healthcare-associated infections; and iii) PSs-embedded films, scaffolds, and hydrogels for regenerative medicine applications.http://www.sciencedirect.com/science/article/pii/S2452199X22003486Antibacterial photodynamic therapyPolymersPhotosensitizersConjugationHydrogelsBiomaterials |
| spellingShingle | Sathishkumar Gnanasekar Gopinath Kasi Xiaodong He Kai Zhang Liqun Xu En-Tang Kang Recent advances in engineered polymeric materials for efficient photodynamic inactivation of bacterial pathogens Bioactive Materials Antibacterial photodynamic therapy Polymers Photosensitizers Conjugation Hydrogels Biomaterials |
| title | Recent advances in engineered polymeric materials for efficient photodynamic inactivation of bacterial pathogens |
| title_full | Recent advances in engineered polymeric materials for efficient photodynamic inactivation of bacterial pathogens |
| title_fullStr | Recent advances in engineered polymeric materials for efficient photodynamic inactivation of bacterial pathogens |
| title_full_unstemmed | Recent advances in engineered polymeric materials for efficient photodynamic inactivation of bacterial pathogens |
| title_short | Recent advances in engineered polymeric materials for efficient photodynamic inactivation of bacterial pathogens |
| title_sort | recent advances in engineered polymeric materials for efficient photodynamic inactivation of bacterial pathogens |
| topic | Antibacterial photodynamic therapy Polymers Photosensitizers Conjugation Hydrogels Biomaterials |
| url | http://www.sciencedirect.com/science/article/pii/S2452199X22003486 |
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