Sex-specific associations of TCF7L2 variants with fasting glucose, type 2 diabetes and coronary heart disease among Turkish adults
Objective: TCF7L2 is a repressor and transactivator of genes, and its variants are strongly associated with diabetes. This study aimed to evaluate the sex-specific relationship between the most common TCF7L2 gene variants (-98368G>T, rs12255372 and -47833C>T, rs7903146) with diabetes a...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
KARE Publishing
2020-10-01
|
| Series: | Anatolian Journal of Cardiology |
| Subjects: | |
| Online Access: | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=anatoljcardiol&un=AJC-57736 |
| _version_ | 1797920813976911872 |
|---|---|
| author | Ayşe Berna Yüzbaşıoğulları Evrim Kömürcü-bayrak Altan Onat Gunay Can Nina Mononen Reijo Laaksonen Mika Kähönen Terho Lehtimäki Nihan Erginel-ünaltuna |
| author_facet | Ayşe Berna Yüzbaşıoğulları Evrim Kömürcü-bayrak Altan Onat Gunay Can Nina Mononen Reijo Laaksonen Mika Kähönen Terho Lehtimäki Nihan Erginel-ünaltuna |
| author_sort | Ayşe Berna Yüzbaşıoğulları |
| collection | DOAJ |
| description | Objective: TCF7L2 is a repressor and transactivator of genes, and its variants are strongly associated with diabetes. This study aimed to evaluate the sex-specific relationship between the most common TCF7L2 gene variants (-98368G>T, rs12255372 and -47833C>T, rs7903146) with diabetes and coronary heart disease in Turkish Adult Risk Factor (TARF) Study.
Methods: Single nucleotide variants (SNVs) have been genotyped using the TaqMan allelic discrimination assays in 2,024 (51.3% in women, age: 55+-11.8) Turkish adults participating in the TARF study. Statistical analyses were used to investigate the association of genotypes with clinical and biochemical measurements.
Results: Among the TARF study participants, 11.7%, 24.3%, 14.1%, and 38.3% had diabetes, hypertension, coronary heart disease (CHD), and obesity, respectively. The frequencies of T allele for -47833C>T and -98368G>T in Turkish adults were determined to be 0.35 and 0.33, respectively. -47833C>T was significantly associated with higher fasting glucose concentrations in all participants, especially in men. Both SNVs were significantly associated with diabetes and CHD in all participants (p<0.05). When study population was stratified according to sex, -98368G>T was associated with diabetes in women (p=0.041) and -47833C>T was associated with diabetes and CHD in men (p=0.018 and p=0.032, respectively). Also, both SNVs and the diplotypes of common haplotype (H1) remained strongly associated with type 2 diabetes after risk factors were adjusted (p<0.05).
Conclusion: T allele homozygosity of two SNVs as well as the diplotype H1-/H1- reflects risk of diabetes primarily in men. Enhanced CHD risk is determined by the presence of diplotype H1-/H1- among nondiabetic participants. |
| first_indexed | 2024-04-10T14:06:50Z |
| format | Article |
| id | doaj.art-a9374cf2e40746a9b741809b24e05ae7 |
| institution | Directory Open Access Journal |
| issn | 2149-2263 |
| language | English |
| last_indexed | 2024-04-10T14:06:50Z |
| publishDate | 2020-10-01 |
| publisher | KARE Publishing |
| record_format | Article |
| series | Anatolian Journal of Cardiology |
| spelling | doaj.art-a9374cf2e40746a9b741809b24e05ae72023-02-15T16:09:57ZengKARE PublishingAnatolian Journal of Cardiology2149-22632020-10-0124532633310.14744/AnatolJCardiol.2020.57736AJC-57736Sex-specific associations of TCF7L2 variants with fasting glucose, type 2 diabetes and coronary heart disease among Turkish adultsAyşe Berna Yüzbaşıoğulları0Evrim Kömürcü-bayrak1Altan Onat2Gunay Can3Nina Mononen4Reijo Laaksonen5Mika Kähönen6Terho Lehtimäki7Nihan Erginel-ünaltuna8Department of Genetics, Aziz Sancar Institute for Experimental Medicine, İstanbul University; İstanbul-TurkeyDepartment of Genetics, Aziz Sancar Institute for Experimental Medicine, İstanbul University; İstanbul-TurkeyEmeritus Professor, Department of Cardiology, Cerrahpaşa Faculty of Medicine, İstanbul University; İstanbul-TurkeyDepartment of Public Health, Cerrahpaşa Faculty of Medicine, İstanbul University; İstanbul-TurkeyDepartment of Clinical Chemistry, Fimlab Laboratories, and Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Life Sciences, University of Tampere; Tampere-FinlandDepartment of Clinical Chemistry, Fimlab Laboratories, and Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Life Sciences, University of Tampere; Tampere-FinlandDepartment of Clinical Physiology, Tampere University Hospital, and Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Life Sciences, University of Tampere; Tampere-FinlandDepartment of Clinical Chemistry, Fimlab Laboratories, and Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Life Sciences, University of Tampere; Tampere-FinlandDepartment of Genetics, Aziz Sancar Institute for Experimental Medicine, İstanbul University; İstanbul-TurkeyObjective: TCF7L2 is a repressor and transactivator of genes, and its variants are strongly associated with diabetes. This study aimed to evaluate the sex-specific relationship between the most common TCF7L2 gene variants (-98368G>T, rs12255372 and -47833C>T, rs7903146) with diabetes and coronary heart disease in Turkish Adult Risk Factor (TARF) Study. Methods: Single nucleotide variants (SNVs) have been genotyped using the TaqMan allelic discrimination assays in 2,024 (51.3% in women, age: 55+-11.8) Turkish adults participating in the TARF study. Statistical analyses were used to investigate the association of genotypes with clinical and biochemical measurements. Results: Among the TARF study participants, 11.7%, 24.3%, 14.1%, and 38.3% had diabetes, hypertension, coronary heart disease (CHD), and obesity, respectively. The frequencies of T allele for -47833C>T and -98368G>T in Turkish adults were determined to be 0.35 and 0.33, respectively. -47833C>T was significantly associated with higher fasting glucose concentrations in all participants, especially in men. Both SNVs were significantly associated with diabetes and CHD in all participants (p<0.05). When study population was stratified according to sex, -98368G>T was associated with diabetes in women (p=0.041) and -47833C>T was associated with diabetes and CHD in men (p=0.018 and p=0.032, respectively). Also, both SNVs and the diplotypes of common haplotype (H1) remained strongly associated with type 2 diabetes after risk factors were adjusted (p<0.05). Conclusion: T allele homozygosity of two SNVs as well as the diplotype H1-/H1- reflects risk of diabetes primarily in men. Enhanced CHD risk is determined by the presence of diplotype H1-/H1- among nondiabetic participants.https://jag.journalagent.com/z4/download_fulltext.asp?pdir=anatoljcardiol&un=AJC-57736tcf7l2variantstype 2 diabetescoronary heart diseasetarf study |
| spellingShingle | Ayşe Berna Yüzbaşıoğulları Evrim Kömürcü-bayrak Altan Onat Gunay Can Nina Mononen Reijo Laaksonen Mika Kähönen Terho Lehtimäki Nihan Erginel-ünaltuna Sex-specific associations of TCF7L2 variants with fasting glucose, type 2 diabetes and coronary heart disease among Turkish adults Anatolian Journal of Cardiology tcf7l2 variants type 2 diabetes coronary heart disease tarf study |
| title | Sex-specific associations of TCF7L2 variants with fasting glucose, type 2 diabetes and coronary heart disease among Turkish adults |
| title_full | Sex-specific associations of TCF7L2 variants with fasting glucose, type 2 diabetes and coronary heart disease among Turkish adults |
| title_fullStr | Sex-specific associations of TCF7L2 variants with fasting glucose, type 2 diabetes and coronary heart disease among Turkish adults |
| title_full_unstemmed | Sex-specific associations of TCF7L2 variants with fasting glucose, type 2 diabetes and coronary heart disease among Turkish adults |
| title_short | Sex-specific associations of TCF7L2 variants with fasting glucose, type 2 diabetes and coronary heart disease among Turkish adults |
| title_sort | sex specific associations of tcf7l2 variants with fasting glucose type 2 diabetes and coronary heart disease among turkish adults |
| topic | tcf7l2 variants type 2 diabetes coronary heart disease tarf study |
| url | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=anatoljcardiol&un=AJC-57736 |
| work_keys_str_mv | AT aysebernayuzbasıogulları sexspecificassociationsoftcf7l2variantswithfastingglucosetype2diabetesandcoronaryheartdiseaseamongturkishadults AT evrimkomurcubayrak sexspecificassociationsoftcf7l2variantswithfastingglucosetype2diabetesandcoronaryheartdiseaseamongturkishadults AT altanonat sexspecificassociationsoftcf7l2variantswithfastingglucosetype2diabetesandcoronaryheartdiseaseamongturkishadults AT gunaycan sexspecificassociationsoftcf7l2variantswithfastingglucosetype2diabetesandcoronaryheartdiseaseamongturkishadults AT ninamononen sexspecificassociationsoftcf7l2variantswithfastingglucosetype2diabetesandcoronaryheartdiseaseamongturkishadults AT reijolaaksonen sexspecificassociationsoftcf7l2variantswithfastingglucosetype2diabetesandcoronaryheartdiseaseamongturkishadults AT mikakahonen sexspecificassociationsoftcf7l2variantswithfastingglucosetype2diabetesandcoronaryheartdiseaseamongturkishadults AT terholehtimaki sexspecificassociationsoftcf7l2variantswithfastingglucosetype2diabetesandcoronaryheartdiseaseamongturkishadults AT nihanerginelunaltuna sexspecificassociationsoftcf7l2variantswithfastingglucosetype2diabetesandcoronaryheartdiseaseamongturkishadults |