| Summary: | Aim: Describe demographics, clinical characteristics, healthcare resource utilization (HCRU) and costs in
people with multiple sclerosis (pwMS) switching to alemtuzumab from other disease-modifying therapies
(DMTs). Patients & methods: Retrospective, observational study of IBM R MarketScan R claims database.
PwMS previously treated with DMTs and initiating alemtuzumab (1 January 2013 to 31 December 2019)
were identified. “Index” was date of alemtuzumab initiation (prescription filled). Results: The study cohort
(n = 341) was primarily female (72%) with (mean ± standard deviation) age 45.1 ± 9.5 years. At index,
duration of MS was 5.3 ± 2.8 years. HCRU (inpatient/outpatient services), outpatient costs (including
MS-specific MRI and emergency room visits) and annualized relapse rate significantly reduced over the 2
years following initiation of alemtuzumab. DMT costs reduced over the same period. Conclusion: Health
economic and clinical benefits were seen following switching to alemtuzumab from other DMTs for
treatment of MS, in this cohort from the USA.
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