Relationship between Atherogenic Dyslipidaemia and Lipid Triad and Scales That Assess Insulin Resistance
Background: Atherogenic dyslipidaemia (AD) and lipid triad (LT) are characterised by high triglyceride levels together with low HDL and normal or high LDL cholesterol and are favoured by a persistent state of insulin resistance (IR), which increases the release of free fatty acids from abdominal adi...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-04-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/15/9/2105 |
| _version_ | 1797602022718963712 |
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| author | Hernán Paublini Angel Arturo López González Carla Busquets-Cortés Pilar Tomas-Gil Pere Riutord-Sbert José Ignacio Ramírez-Manent |
| author_facet | Hernán Paublini Angel Arturo López González Carla Busquets-Cortés Pilar Tomas-Gil Pere Riutord-Sbert José Ignacio Ramírez-Manent |
| author_sort | Hernán Paublini |
| collection | DOAJ |
| description | Background: Atherogenic dyslipidaemia (AD) and lipid triad (LT) are characterised by high triglyceride levels together with low HDL and normal or high LDL cholesterol and are favoured by a persistent state of insulin resistance (IR), which increases the release of free fatty acids from abdominal adipose tissue. This alteration in the lipid profile favours the accelerated development of atherosclerosis, which is the most important cause of morbidity and mortality in all countries in the developed and developing world. One of the elements that plays a major role in the genesis of AD is IR. The aim of this study was to determine the relationship between variables that assess atherogenic risk (AD and LT) and scales that assess the risk of presenting insulin resistance. Methods: A descriptive cross-sectional study of 418,343 workers was conducted to evaluate atherogenic dyslipidaemia and lipid triad; a relationship with three insulin resistance risk scales (Triglycerides/HDL, TyG index, METS-IR) was established. The usefulness of IR risk scales for predicting AD and LT was calculated by applying ROC curves, obtaining the area under the curve (AUC) and cut-off points with their sensitivity, specificity, and Youden index. Multivariate analysis was performed by binary logistic regression. Results: The prevalence of high-risk values for insulin resistance with all of the scales is much higher in people with AD and LT compared to those without. The ROC curves present us with an AUC with the three insulin resistance risk scales for the two dyslipidaemias studied with figures ranging between 0.856 and 0.991, which implies that the results are good/very good. Conclusions: A relationship between atherogenic dyslipidaemia and the three insulin resistance risk scales assessed is revealed, with higher IR mean values and prevalence in people with atherogenic dyslipidaemia and lipid triad. The three scales make it possible to adequately classify the presence of AD and LT. The highest AUC is presented by the triglycerides/HDL scale, with a result close to 1. METS-IR is the most recommended formula to estimate insulin resistance. |
| first_indexed | 2024-03-11T04:10:19Z |
| format | Article |
| id | doaj.art-a93a68122e594616a1202e069fc4f4c8 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-11T04:10:19Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-a93a68122e594616a1202e069fc4f4c82023-11-17T23:29:11ZengMDPI AGNutrients2072-66432023-04-01159210510.3390/nu15092105Relationship between Atherogenic Dyslipidaemia and Lipid Triad and Scales That Assess Insulin ResistanceHernán Paublini0Angel Arturo López González1Carla Busquets-Cortés2Pilar Tomas-Gil3Pere Riutord-Sbert4José Ignacio Ramírez-Manent5Research Group Adema Salud IUNICS, 07003 Palma, SpainResearch Group Adema Salud IUNICS, 07003 Palma, SpainResearch Group Adema Salud IUNICS, 07003 Palma, SpainResearch Group Adema Salud IUNICS, 07003 Palma, SpainResearch Group Adema Salud IUNICS, 07003 Palma, SpainResearch Group Adema Salud IUNICS, 07003 Palma, SpainBackground: Atherogenic dyslipidaemia (AD) and lipid triad (LT) are characterised by high triglyceride levels together with low HDL and normal or high LDL cholesterol and are favoured by a persistent state of insulin resistance (IR), which increases the release of free fatty acids from abdominal adipose tissue. This alteration in the lipid profile favours the accelerated development of atherosclerosis, which is the most important cause of morbidity and mortality in all countries in the developed and developing world. One of the elements that plays a major role in the genesis of AD is IR. The aim of this study was to determine the relationship between variables that assess atherogenic risk (AD and LT) and scales that assess the risk of presenting insulin resistance. Methods: A descriptive cross-sectional study of 418,343 workers was conducted to evaluate atherogenic dyslipidaemia and lipid triad; a relationship with three insulin resistance risk scales (Triglycerides/HDL, TyG index, METS-IR) was established. The usefulness of IR risk scales for predicting AD and LT was calculated by applying ROC curves, obtaining the area under the curve (AUC) and cut-off points with their sensitivity, specificity, and Youden index. Multivariate analysis was performed by binary logistic regression. Results: The prevalence of high-risk values for insulin resistance with all of the scales is much higher in people with AD and LT compared to those without. The ROC curves present us with an AUC with the three insulin resistance risk scales for the two dyslipidaemias studied with figures ranging between 0.856 and 0.991, which implies that the results are good/very good. Conclusions: A relationship between atherogenic dyslipidaemia and the three insulin resistance risk scales assessed is revealed, with higher IR mean values and prevalence in people with atherogenic dyslipidaemia and lipid triad. The three scales make it possible to adequately classify the presence of AD and LT. The highest AUC is presented by the triglycerides/HDL scale, with a result close to 1. METS-IR is the most recommended formula to estimate insulin resistance.https://www.mdpi.com/2072-6643/15/9/2105atherogenic dyslipidaemialipid triadinsulin resistanceatherogenic risk |
| spellingShingle | Hernán Paublini Angel Arturo López González Carla Busquets-Cortés Pilar Tomas-Gil Pere Riutord-Sbert José Ignacio Ramírez-Manent Relationship between Atherogenic Dyslipidaemia and Lipid Triad and Scales That Assess Insulin Resistance Nutrients atherogenic dyslipidaemia lipid triad insulin resistance atherogenic risk |
| title | Relationship between Atherogenic Dyslipidaemia and Lipid Triad and Scales That Assess Insulin Resistance |
| title_full | Relationship between Atherogenic Dyslipidaemia and Lipid Triad and Scales That Assess Insulin Resistance |
| title_fullStr | Relationship between Atherogenic Dyslipidaemia and Lipid Triad and Scales That Assess Insulin Resistance |
| title_full_unstemmed | Relationship between Atherogenic Dyslipidaemia and Lipid Triad and Scales That Assess Insulin Resistance |
| title_short | Relationship between Atherogenic Dyslipidaemia and Lipid Triad and Scales That Assess Insulin Resistance |
| title_sort | relationship between atherogenic dyslipidaemia and lipid triad and scales that assess insulin resistance |
| topic | atherogenic dyslipidaemia lipid triad insulin resistance atherogenic risk |
| url | https://www.mdpi.com/2072-6643/15/9/2105 |
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