Human B Cell Responses to Dominant and Subdominant Antigens Induced by a Meningococcal Outer Membrane Vesicle Vaccine in a Phase I Trial

Human B Cell Responses to Dominant and Subdominant Antigens Induced by a Meningococcal Outer Membrane Vesicle Vaccine in a Phase I Trial

ABSTRACT Neisseria meningitidis outer membrane vesicle (OMV) vaccines are safe and provide strain-specific protection against invasive meningococcal disease (IMD) primarily by inducing serum bactericidal antibodies against the outer membrane proteins (OMP). To design broader coverage vaccines, knowl...

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Bibliographic Details
Main Authors: Christine S. Rollier, Christina Dold, Leanne Marsay, Aline Linder, Christopher A. Green, Manish Sadarangani, Gunnstein Norheim, Jeremy P. Derrick, Ian M. Feavers, Martin C. J. Maiden, Andrew J. Pollard
Format: Article
Language:English
Published: American Society for Microbiology 2022-02-01
Series:mSphere
Subjects:
Neisseria
bacteria
genetic modification
infection
meningitidis
meningitis
Online Access:https://journals.asm.org/doi/10.1128/msphere.00674-21

Internet

https://journals.asm.org/doi/10.1128/msphere.00674-21

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