Successful treatment of herpes simplex virus associated hemophagocytic syndrome coexisting with ARDS with intravenous immunoglobulin in acute myeloid leukemia patient

Hemophagocytic lymphohistiocytosis (HLH) is a rare clinical syndrome characterized by excessive macrophage function. The diagnosis of HLH in adults is challenging because initial signs and symptoms of HLH mimic common infections. Herein is described a case of HSV infection causing virus-associated h...

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Main Authors: I-Hsuan Huang, Wei-Chun Lin, Ping-Ying Chang
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2017-09-01
Series:Journal of Cancer Research and Practice
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2311300616301859
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author I-Hsuan Huang
Wei-Chun Lin
Ping-Ying Chang
author_facet I-Hsuan Huang
Wei-Chun Lin
Ping-Ying Chang
author_sort I-Hsuan Huang
collection DOAJ
description Hemophagocytic lymphohistiocytosis (HLH) is a rare clinical syndrome characterized by excessive macrophage function. The diagnosis of HLH in adults is challenging because initial signs and symptoms of HLH mimic common infections. Herein is described a case of HSV infection causing virus-associated hemophagocytic syndrome (VAHS) with severe hemodynamic distress. This patient manifested acute respiratory distress syndrome (ARDS), which responded well to intravenous immunoglobulin. Patients with herpes simplex virus-associated hemophagocytic syndrome coexisting with ARDS may be given a trial of immune globulin. However, there are few reported cases of AML occurring with VAHS in the literature, which were successfully treated with IVIG; therefore, this finding requires further investigation in a similar setting.
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spelling doaj.art-a93cfa8bd43d4f8dbb363920c38e07932022-12-22T03:53:17ZengWolters Kluwer Medknow PublicationsJournal of Cancer Research and Practice2311-30062017-09-014310911010.1016/j.jcrpr.2017.02.003Successful treatment of herpes simplex virus associated hemophagocytic syndrome coexisting with ARDS with intravenous immunoglobulin in acute myeloid leukemia patientI-Hsuan Huang0Wei-Chun Lin1Ping-Ying Chang2Department of Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, TaiwanDepartment of Surgery, Song Shan Branch, Tri-Service General Hospital, National Defense Medical Center, Taipei, TaiwanDivision of Hematology Oncology, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, TaiwanHemophagocytic lymphohistiocytosis (HLH) is a rare clinical syndrome characterized by excessive macrophage function. The diagnosis of HLH in adults is challenging because initial signs and symptoms of HLH mimic common infections. Herein is described a case of HSV infection causing virus-associated hemophagocytic syndrome (VAHS) with severe hemodynamic distress. This patient manifested acute respiratory distress syndrome (ARDS), which responded well to intravenous immunoglobulin. Patients with herpes simplex virus-associated hemophagocytic syndrome coexisting with ARDS may be given a trial of immune globulin. However, there are few reported cases of AML occurring with VAHS in the literature, which were successfully treated with IVIG; therefore, this finding requires further investigation in a similar setting.http://www.sciencedirect.com/science/article/pii/S2311300616301859Hemophagocytic syndromeIntravenous immunoglobulinAcute respiratory distress syndrome
spellingShingle I-Hsuan Huang
Wei-Chun Lin
Ping-Ying Chang
Successful treatment of herpes simplex virus associated hemophagocytic syndrome coexisting with ARDS with intravenous immunoglobulin in acute myeloid leukemia patient
Journal of Cancer Research and Practice
Hemophagocytic syndrome
Intravenous immunoglobulin
Acute respiratory distress syndrome
title Successful treatment of herpes simplex virus associated hemophagocytic syndrome coexisting with ARDS with intravenous immunoglobulin in acute myeloid leukemia patient
title_full Successful treatment of herpes simplex virus associated hemophagocytic syndrome coexisting with ARDS with intravenous immunoglobulin in acute myeloid leukemia patient
title_fullStr Successful treatment of herpes simplex virus associated hemophagocytic syndrome coexisting with ARDS with intravenous immunoglobulin in acute myeloid leukemia patient
title_full_unstemmed Successful treatment of herpes simplex virus associated hemophagocytic syndrome coexisting with ARDS with intravenous immunoglobulin in acute myeloid leukemia patient
title_short Successful treatment of herpes simplex virus associated hemophagocytic syndrome coexisting with ARDS with intravenous immunoglobulin in acute myeloid leukemia patient
title_sort successful treatment of herpes simplex virus associated hemophagocytic syndrome coexisting with ards with intravenous immunoglobulin in acute myeloid leukemia patient
topic Hemophagocytic syndrome
Intravenous immunoglobulin
Acute respiratory distress syndrome
url http://www.sciencedirect.com/science/article/pii/S2311300616301859
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