Chemical Constituents from Roots of <i>Sophora davidii</i> (Franch.) Skeels and Their Glucose Transporter 4 Translocation Activities
<i>Sophora davidii</i> (Franch.) Skeels is a multi-purpose traditional medicine that has long been used for the treatment of various diseases. To discover the potential bioactive composition of <i>S. davidii</i>, a chemical investigation was thus performed. In this research,...
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MDPI AG
2021-02-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/26/3/756 |
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| author | Kangdi Li Yuanren Ma Tongxi Zhou Xinzhou Yang Ho-Young Choi |
| author_facet | Kangdi Li Yuanren Ma Tongxi Zhou Xinzhou Yang Ho-Young Choi |
| author_sort | Kangdi Li |
| collection | DOAJ |
| description | <i>Sophora davidii</i> (Franch.) Skeels is a multi-purpose traditional medicine that has long been used for the treatment of various diseases. To discover the potential bioactive composition of <i>S. davidii</i>, a chemical investigation was thus performed. In this research, two new stilbene oligomers, Davidiol E–F (<b>1</b>–<b>2</b>), one new 4-aryl-substituted isoflavan Davidinin A (<b>3</b>), and one new 2-arylbenzofuran dimer, Shandougenine C (<b>4</b>), as well as six known compounds (<b>5</b>–<b>10</b>) were obtained from the ethyl acetate fraction of <i>Sophora davidii</i> (Franch.) Skeels. The structures of new compounds were established by extensive 1D and 2D nuclear magnetic resonance (NMR) spectra with mass spectroscopy data. The absolute configuration of <b>1</b>–<b>3</b> was assigned by comparing its experimental and calculated electronic circular dichroism (ECD) spectra. Compounds <b>1</b>–<b>10</b> promoted glucose transporter 4 (GLUT-4) translocations by the range of 1.28–2.60 folds, respectively. Compound <b>9</b> showed the most potent glucose transporter 4 translocations with 1.60 fold enhancement. The result attained in this study indicated that the separation and characterization of these compounds plays an important role in the research and development of new anti-diabetic drugs and pharmaceutical industry. |
| first_indexed | 2024-03-09T06:09:36Z |
| format | Article |
| id | doaj.art-a93db122e4c849289899f5397afb7895 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-09T06:09:36Z |
| publishDate | 2021-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-a93db122e4c849289899f5397afb78952023-12-03T11:59:45ZengMDPI AGMolecules1420-30492021-02-0126375610.3390/molecules26030756Chemical Constituents from Roots of <i>Sophora davidii</i> (Franch.) Skeels and Their Glucose Transporter 4 Translocation ActivitiesKangdi Li0Yuanren Ma1Tongxi Zhou2Xinzhou Yang3Ho-Young Choi4School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, ChinaSchool of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, ChinaSchool of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, ChinaSchool of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, ChinaCollege of Korean Medicine, Kyung Hee University, Seoul 02447, Korea<i>Sophora davidii</i> (Franch.) Skeels is a multi-purpose traditional medicine that has long been used for the treatment of various diseases. To discover the potential bioactive composition of <i>S. davidii</i>, a chemical investigation was thus performed. In this research, two new stilbene oligomers, Davidiol E–F (<b>1</b>–<b>2</b>), one new 4-aryl-substituted isoflavan Davidinin A (<b>3</b>), and one new 2-arylbenzofuran dimer, Shandougenine C (<b>4</b>), as well as six known compounds (<b>5</b>–<b>10</b>) were obtained from the ethyl acetate fraction of <i>Sophora davidii</i> (Franch.) Skeels. The structures of new compounds were established by extensive 1D and 2D nuclear magnetic resonance (NMR) spectra with mass spectroscopy data. The absolute configuration of <b>1</b>–<b>3</b> was assigned by comparing its experimental and calculated electronic circular dichroism (ECD) spectra. Compounds <b>1</b>–<b>10</b> promoted glucose transporter 4 (GLUT-4) translocations by the range of 1.28–2.60 folds, respectively. Compound <b>9</b> showed the most potent glucose transporter 4 translocations with 1.60 fold enhancement. The result attained in this study indicated that the separation and characterization of these compounds plays an important role in the research and development of new anti-diabetic drugs and pharmaceutical industry.https://www.mdpi.com/1420-3049/26/3/756<i>Sophora davidii</i> (Franch.) Skeelsstilbene oligomersisoflavanarylbenzofuranGLUT-4ECD |
| spellingShingle | Kangdi Li Yuanren Ma Tongxi Zhou Xinzhou Yang Ho-Young Choi Chemical Constituents from Roots of <i>Sophora davidii</i> (Franch.) Skeels and Their Glucose Transporter 4 Translocation Activities Molecules <i>Sophora davidii</i> (Franch.) Skeels stilbene oligomers isoflavan arylbenzofuran GLUT-4 ECD |
| title | Chemical Constituents from Roots of <i>Sophora davidii</i> (Franch.) Skeels and Their Glucose Transporter 4 Translocation Activities |
| title_full | Chemical Constituents from Roots of <i>Sophora davidii</i> (Franch.) Skeels and Their Glucose Transporter 4 Translocation Activities |
| title_fullStr | Chemical Constituents from Roots of <i>Sophora davidii</i> (Franch.) Skeels and Their Glucose Transporter 4 Translocation Activities |
| title_full_unstemmed | Chemical Constituents from Roots of <i>Sophora davidii</i> (Franch.) Skeels and Their Glucose Transporter 4 Translocation Activities |
| title_short | Chemical Constituents from Roots of <i>Sophora davidii</i> (Franch.) Skeels and Their Glucose Transporter 4 Translocation Activities |
| title_sort | chemical constituents from roots of i sophora davidii i franch skeels and their glucose transporter 4 translocation activities |
| topic | <i>Sophora davidii</i> (Franch.) Skeels stilbene oligomers isoflavan arylbenzofuran GLUT-4 ECD |
| url | https://www.mdpi.com/1420-3049/26/3/756 |
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