A Review of Advanced Biomaterials and Cells for the Production of Bone Organoid
Rapid advancements in traditional bone tissue engineering have led to innovation in bone repair models and the resolution of insurmountable clinical issues like graft scarcity. The pathophysiological process of treating bone disease, however, is a multidimensional and multimodal regenerative regulat...
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| Format: | Article |
| Language: | English |
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Wiley-VCH
2023-08-01
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| Series: | Small Science |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/smsc.202300027 |
| _version_ | 1797739707413561344 |
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| author | Chao Li Yipu Zhang Yawei Du Zhiyong Hou Yingze Zhang Wenguo Cui Wei Chen |
| author_facet | Chao Li Yipu Zhang Yawei Du Zhiyong Hou Yingze Zhang Wenguo Cui Wei Chen |
| author_sort | Chao Li |
| collection | DOAJ |
| description | Rapid advancements in traditional bone tissue engineering have led to innovation in bone repair models and the resolution of insurmountable clinical issues like graft scarcity. The pathophysiological process of treating bone disease, however, is a multidimensional and multimodal regenerative regulatory mechanism that includes numerous immune, inflammatory, or metabolic responses related to the graft or the organism itself. Based on a 3D in vitro cell culture system that is remarkably identical to the body's bone tissue, the bone organoid is a biomimicking bone organ environment. It can accurately mimic the actual repair and regeneration condition in vivo because it shares the same physiological function, structure, morphology, and metabolic process as endogenous bone tissue. As a disruptive regenerative medicine technology, it has wide application prospects in the fields of organ development, gene editing, disease modeling, and precision therapy. Herein, the development process and physiological basis of different cell‐based bone organoids are reviewed, the current status of the application of different materials, cells, and construction methods for building bone organoids is described, and the prospects and challenges for the development of bone organoids in future medical fields is discussed. |
| first_indexed | 2024-03-12T14:02:03Z |
| format | Article |
| id | doaj.art-a9409e270f2049599f5fcd0cd19c8cad |
| institution | Directory Open Access Journal |
| issn | 2688-4046 |
| language | English |
| last_indexed | 2024-03-12T14:02:03Z |
| publishDate | 2023-08-01 |
| publisher | Wiley-VCH |
| record_format | Article |
| series | Small Science |
| spelling | doaj.art-a9409e270f2049599f5fcd0cd19c8cad2023-08-22T05:02:13ZengWiley-VCHSmall Science2688-40462023-08-0138n/an/a10.1002/smsc.202300027A Review of Advanced Biomaterials and Cells for the Production of Bone OrganoidChao Li0Yipu Zhang1Yawei Du2Zhiyong Hou3Yingze Zhang4Wenguo Cui5Wei Chen6Department of Orthopaedic Surgery Key Laboratory of Biomechanics of Hebei Province Orthopaedic Research Institution of Hebei Province NHC Key Laboratory of Intelligent Orthopaedic Equipment The Third Hospital of Hebei Medical University No.139 Ziqiang Road Shijiazhuang 050051 P. R. ChinaDepartment of Orthopaedic Surgery Key Laboratory of Biomechanics of Hebei Province Orthopaedic Research Institution of Hebei Province NHC Key Laboratory of Intelligent Orthopaedic Equipment The Third Hospital of Hebei Medical University No.139 Ziqiang Road Shijiazhuang 050051 P. R. ChinaDepartment of Orthopaedics Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases Shanghai Institute of Traumatology and Orthopaedics Ruijin Hospital Shanghai Jiao Tong University School of Medicine 197 Ruijin 2nd Road Shanghai 200025 P. R. ChinaDepartment of Orthopaedic Surgery Key Laboratory of Biomechanics of Hebei Province Orthopaedic Research Institution of Hebei Province NHC Key Laboratory of Intelligent Orthopaedic Equipment The Third Hospital of Hebei Medical University No.139 Ziqiang Road Shijiazhuang 050051 P. R. ChinaDepartment of Orthopaedic Surgery Key Laboratory of Biomechanics of Hebei Province Orthopaedic Research Institution of Hebei Province NHC Key Laboratory of Intelligent Orthopaedic Equipment The Third Hospital of Hebei Medical University No.139 Ziqiang Road Shijiazhuang 050051 P. R. ChinaDepartment of Orthopaedics Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases Shanghai Institute of Traumatology and Orthopaedics Ruijin Hospital Shanghai Jiao Tong University School of Medicine 197 Ruijin 2nd Road Shanghai 200025 P. R. ChinaDepartment of Orthopaedic Surgery Key Laboratory of Biomechanics of Hebei Province Orthopaedic Research Institution of Hebei Province NHC Key Laboratory of Intelligent Orthopaedic Equipment The Third Hospital of Hebei Medical University No.139 Ziqiang Road Shijiazhuang 050051 P. R. ChinaRapid advancements in traditional bone tissue engineering have led to innovation in bone repair models and the resolution of insurmountable clinical issues like graft scarcity. The pathophysiological process of treating bone disease, however, is a multidimensional and multimodal regenerative regulatory mechanism that includes numerous immune, inflammatory, or metabolic responses related to the graft or the organism itself. Based on a 3D in vitro cell culture system that is remarkably identical to the body's bone tissue, the bone organoid is a biomimicking bone organ environment. It can accurately mimic the actual repair and regeneration condition in vivo because it shares the same physiological function, structure, morphology, and metabolic process as endogenous bone tissue. As a disruptive regenerative medicine technology, it has wide application prospects in the fields of organ development, gene editing, disease modeling, and precision therapy. Herein, the development process and physiological basis of different cell‐based bone organoids are reviewed, the current status of the application of different materials, cells, and construction methods for building bone organoids is described, and the prospects and challenges for the development of bone organoids in future medical fields is discussed.https://doi.org/10.1002/smsc.202300027bone organoidsorthopedic disease modelsregenerative medicinescaffold materials |
| spellingShingle | Chao Li Yipu Zhang Yawei Du Zhiyong Hou Yingze Zhang Wenguo Cui Wei Chen A Review of Advanced Biomaterials and Cells for the Production of Bone Organoid Small Science bone organoids orthopedic disease models regenerative medicine scaffold materials |
| title | A Review of Advanced Biomaterials and Cells for the Production of Bone Organoid |
| title_full | A Review of Advanced Biomaterials and Cells for the Production of Bone Organoid |
| title_fullStr | A Review of Advanced Biomaterials and Cells for the Production of Bone Organoid |
| title_full_unstemmed | A Review of Advanced Biomaterials and Cells for the Production of Bone Organoid |
| title_short | A Review of Advanced Biomaterials and Cells for the Production of Bone Organoid |
| title_sort | review of advanced biomaterials and cells for the production of bone organoid |
| topic | bone organoids orthopedic disease models regenerative medicine scaffold materials |
| url | https://doi.org/10.1002/smsc.202300027 |
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