Effects of cigarette smoke extract derived from heated tobacco products on the proliferation of lung cancer stem cells
Epidemiological studies have suggested that cigarette smoking can increase a person’s risk of developing several types of cancer, including lung cancer. Lung cancer originates from cancer stem cells (CSCs), which constitute a minor cell population in tumors, and contribute to drug resistance and rec...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-01-01
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| Series: | Toxicology Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2214750022001378 |
| _version_ | 1811188598554230784 |
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| author | Naoya Hirata Takahiro Horinouchi Yasunari Kanda |
| author_facet | Naoya Hirata Takahiro Horinouchi Yasunari Kanda |
| author_sort | Naoya Hirata |
| collection | DOAJ |
| description | Epidemiological studies have suggested that cigarette smoking can increase a person’s risk of developing several types of cancer, including lung cancer. Lung cancer originates from cancer stem cells (CSCs), which constitute a minor cell population in tumors, and contribute to drug resistance and recurrence. Heated tobacco products (HTPs) produce aerosols that contain nicotine and toxic chemicals. Current evidence, however, is insufficient to accurately determine if HTPs are less harmful than burned cigarettes. This study has investigated the effects of cigarette smoke extract (CSE) from HTPs on lung CSCs in lung cancer cell lines. We found that CSEs induced the proliferation of lung CSCs and increased the expression levels of stem cell markers. In addition, CSE induced epithelial-mesenchymal transition (EMT) expression and cytokine production. These results suggest that HTPs can induce lung CSCs in vitro. |
| first_indexed | 2024-04-11T14:21:30Z |
| format | Article |
| id | doaj.art-a940b4f1a29f415bbd426e21383e2b3d |
| institution | Directory Open Access Journal |
| issn | 2214-7500 |
| language | English |
| last_indexed | 2024-04-11T14:21:30Z |
| publishDate | 2022-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Toxicology Reports |
| spelling | doaj.art-a940b4f1a29f415bbd426e21383e2b3d2022-12-22T04:19:03ZengElsevierToxicology Reports2214-75002022-01-01912731280Effects of cigarette smoke extract derived from heated tobacco products on the proliferation of lung cancer stem cellsNaoya Hirata0Takahiro Horinouchi1Yasunari Kanda2Division of Pharmacology, National Institute of Health Sciences, Kanagawa, JapanDepartment of Cellular Pharmacology, Graduate School of Medicine, Hokkaido University, Sapporo, JapanDivision of Pharmacology, National Institute of Health Sciences, Kanagawa, Japan; Correspondence to: Division of Pharmacology, National Institute of Health Sciences, Tonomachi 25–26, Kawasaki-ku, Kawasaki, Kanagawa 210–9501, Japan.Epidemiological studies have suggested that cigarette smoking can increase a person’s risk of developing several types of cancer, including lung cancer. Lung cancer originates from cancer stem cells (CSCs), which constitute a minor cell population in tumors, and contribute to drug resistance and recurrence. Heated tobacco products (HTPs) produce aerosols that contain nicotine and toxic chemicals. Current evidence, however, is insufficient to accurately determine if HTPs are less harmful than burned cigarettes. This study has investigated the effects of cigarette smoke extract (CSE) from HTPs on lung CSCs in lung cancer cell lines. We found that CSEs induced the proliferation of lung CSCs and increased the expression levels of stem cell markers. In addition, CSE induced epithelial-mesenchymal transition (EMT) expression and cytokine production. These results suggest that HTPs can induce lung CSCs in vitro.http://www.sciencedirect.com/science/article/pii/S2214750022001378Heated tobacco productsCigarette smoke extractCancer stem cellsEpithelial-mesenchymal transition |
| spellingShingle | Naoya Hirata Takahiro Horinouchi Yasunari Kanda Effects of cigarette smoke extract derived from heated tobacco products on the proliferation of lung cancer stem cells Toxicology Reports Heated tobacco products Cigarette smoke extract Cancer stem cells Epithelial-mesenchymal transition |
| title | Effects of cigarette smoke extract derived from heated tobacco products on the proliferation of lung cancer stem cells |
| title_full | Effects of cigarette smoke extract derived from heated tobacco products on the proliferation of lung cancer stem cells |
| title_fullStr | Effects of cigarette smoke extract derived from heated tobacco products on the proliferation of lung cancer stem cells |
| title_full_unstemmed | Effects of cigarette smoke extract derived from heated tobacco products on the proliferation of lung cancer stem cells |
| title_short | Effects of cigarette smoke extract derived from heated tobacco products on the proliferation of lung cancer stem cells |
| title_sort | effects of cigarette smoke extract derived from heated tobacco products on the proliferation of lung cancer stem cells |
| topic | Heated tobacco products Cigarette smoke extract Cancer stem cells Epithelial-mesenchymal transition |
| url | http://www.sciencedirect.com/science/article/pii/S2214750022001378 |
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