Mismatch Negativity Using Frequency Difference in Healthy Young Adults: Latency and Amplitude
Latency and amplitude are the measurement parameters of mismatch negativity (MMN). The values of the parameters vary sensitively with the stimulus paradigm. A paradigm using the frequency difference of sounds for the MMN study is well known. This study obtained the reference values of the parameters...
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The Korean Society for Clinical Laboratory Science
2020-09-01
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| Series: | Korean Journal of Clinical Laboratory Science |
| Subjects: |
| _version_ | 1828473318613712896 |
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| author | Seokwon Jung Young-Soo Kim Tae-Won Yang Do-Hyung Kim Min Su Kim Sang Hyeon Bae Ga-In Kim Oh-Young Kwon |
| author_facet | Seokwon Jung Young-Soo Kim Tae-Won Yang Do-Hyung Kim Min Su Kim Sang Hyeon Bae Ga-In Kim Oh-Young Kwon |
| author_sort | Seokwon Jung |
| collection | DOAJ |
| description | Latency and amplitude are the measurement parameters of mismatch negativity (MMN). The values of the parameters vary sensitively with the stimulus paradigm. A paradigm using the frequency difference of sounds for the MMN study is well known. This study obtained the reference values of the parameters in healthy young adults by performing the MMN study using the frequency paradigm. The authors recruited ten healthy adults. Their average age was 25.5 years; three were female, and seven were male. On the auditory paradigm for the MMN study, the frequency of sound was 1000 Hz for the standard stimulus, and 1032 Hz for the deviant stimulus. The mean values of latency and amplitude of MMN were 202 ms and 1.88 μV at Fz, 207 ms, and 1.46 μV at Cz, 212 ms, and 1.10 μV at C3, and 214 ms and 1.45 μV at C4. There was no correlation between the latency and amplitude of MMN. This study presented the reference values of the latency and amplitude of the MMN using a standard paradigm that is easy to apply. This information may make the MMN useful for clinical applications and basic research. |
| first_indexed | 2024-12-11T05:42:40Z |
| format | Article |
| id | doaj.art-a94188a5a7a1432586895c53a99fcdd5 |
| institution | Directory Open Access Journal |
| issn | 1738-3544 2288-1662 |
| language | English |
| last_indexed | 2024-12-11T05:42:40Z |
| publishDate | 2020-09-01 |
| publisher | The Korean Society for Clinical Laboratory Science |
| record_format | Article |
| series | Korean Journal of Clinical Laboratory Science |
| spelling | doaj.art-a94188a5a7a1432586895c53a99fcdd52022-12-22T01:19:05ZengThe Korean Society for Clinical Laboratory ScienceKorean Journal of Clinical Laboratory Science1738-35442288-16622020-09-0152319420110.15324/kjcls.2020.52.3.194Mismatch Negativity Using Frequency Difference in Healthy Young Adults: Latency and AmplitudeSeokwon Jung0Young-Soo Kim1Tae-Won Yang2Do-Hyung Kim3Min Su Kim4Sang Hyeon Bae5Ga-In Kim6Oh-Young Kwon7https://orcid.org/0000-0001-9576-1926Department of Neurology, Gyeongsang National University Hospital, Jinju, KoreaDepartment of Neurology, Gyeongsang National University Hospital, Jinju, KoreaDepartment of Neurology, Gyeongsang National University Changwon Hospital, Changwon, KoreaDepartment of Neurology, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, KoreaDepartment of Neurology, Gyeongsang National University Hospital, Jinju, KoreaDepartment of Neurology, Gyeongsang National University Hospital, Jinju, KoreaDepartment of Neurology, Gyeongsang National University Hospital, Jinju, KoreaDepartment of Neurology, Gyeongsang National University Hospital, Jinju, KoreaLatency and amplitude are the measurement parameters of mismatch negativity (MMN). The values of the parameters vary sensitively with the stimulus paradigm. A paradigm using the frequency difference of sounds for the MMN study is well known. This study obtained the reference values of the parameters in healthy young adults by performing the MMN study using the frequency paradigm. The authors recruited ten healthy adults. Their average age was 25.5 years; three were female, and seven were male. On the auditory paradigm for the MMN study, the frequency of sound was 1000 Hz for the standard stimulus, and 1032 Hz for the deviant stimulus. The mean values of latency and amplitude of MMN were 202 ms and 1.88 μV at Fz, 207 ms, and 1.46 μV at Cz, 212 ms, and 1.10 μV at C3, and 214 ms and 1.45 μV at C4. There was no correlation between the latency and amplitude of MMN. This study presented the reference values of the latency and amplitude of the MMN using a standard paradigm that is easy to apply. This information may make the MMN useful for clinical applications and basic research.acoustic stimulationcortical excitabilityelectrophysiology |
| spellingShingle | Seokwon Jung Young-Soo Kim Tae-Won Yang Do-Hyung Kim Min Su Kim Sang Hyeon Bae Ga-In Kim Oh-Young Kwon Mismatch Negativity Using Frequency Difference in Healthy Young Adults: Latency and Amplitude Korean Journal of Clinical Laboratory Science acoustic stimulation cortical excitability electrophysiology |
| title | Mismatch Negativity Using Frequency Difference in Healthy Young Adults: Latency and Amplitude |
| title_full | Mismatch Negativity Using Frequency Difference in Healthy Young Adults: Latency and Amplitude |
| title_fullStr | Mismatch Negativity Using Frequency Difference in Healthy Young Adults: Latency and Amplitude |
| title_full_unstemmed | Mismatch Negativity Using Frequency Difference in Healthy Young Adults: Latency and Amplitude |
| title_short | Mismatch Negativity Using Frequency Difference in Healthy Young Adults: Latency and Amplitude |
| title_sort | mismatch negativity using frequency difference in healthy young adults latency and amplitude |
| topic | acoustic stimulation cortical excitability electrophysiology |
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