<i>CDK12</i>: A Potent Target and Biomarker for Human Cancer Therapy
Cyclin-dependent kinases (CDKs) are a group of serine/threonine protein kinases and play crucial roles in various cellular processes by regulating cell cycle and gene transcription. Cyclin-dependent kinase 12 (<i>CDK12</i>) is an important transcription-associated CDK. It shows versatile...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-06-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/9/6/1483 |
| _version_ | 1797564970199678976 |
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| author | Shujing Liang Lifang Hu Zixiang Wu Zhihao Chen Shuyu Liu Xia Xu Airong Qian |
| author_facet | Shujing Liang Lifang Hu Zixiang Wu Zhihao Chen Shuyu Liu Xia Xu Airong Qian |
| author_sort | Shujing Liang |
| collection | DOAJ |
| description | Cyclin-dependent kinases (CDKs) are a group of serine/threonine protein kinases and play crucial roles in various cellular processes by regulating cell cycle and gene transcription. Cyclin-dependent kinase 12 (<i>CDK12</i>) is an important transcription-associated CDK. It shows versatile roles in regulating gene transcription, RNA splicing, translation, DNA damage response (DDR), cell cycle progression and cell proliferation. Recently, increasing evidence demonstrates the important role of <i>CDK12</i> in various human cancers, illustrating it as both a biomarker of cancer and a potential target for cancer therapy. Here, we summarize the current knowledge of <i>CDK12</i>, and review the research advances of <i>CDK12</i>′s biological functions, especially its role in human cancers and as a potential target and biomarker for cancer therapy. |
| first_indexed | 2024-03-10T19:05:19Z |
| format | Article |
| id | doaj.art-a942f8281f4f4738829e6866a73f99d4 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T19:05:19Z |
| publishDate | 2020-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-a942f8281f4f4738829e6866a73f99d42023-11-20T04:12:07ZengMDPI AGCells2073-44092020-06-0196148310.3390/cells9061483<i>CDK12</i>: A Potent Target and Biomarker for Human Cancer TherapyShujing Liang0Lifang Hu1Zixiang Wu2Zhihao Chen3Shuyu Liu4Xia Xu5Airong Qian6Laboratory for Bone Metabolism, Xi’an Key Laboratory of Special Medicine and Health Engineering, Northwestern Polytechnical University, Xi’an 710072, ChinaLaboratory for Bone Metabolism, Xi’an Key Laboratory of Special Medicine and Health Engineering, Northwestern Polytechnical University, Xi’an 710072, ChinaLaboratory for Bone Metabolism, Xi’an Key Laboratory of Special Medicine and Health Engineering, Northwestern Polytechnical University, Xi’an 710072, ChinaLaboratory for Bone Metabolism, Xi’an Key Laboratory of Special Medicine and Health Engineering, Northwestern Polytechnical University, Xi’an 710072, ChinaLaboratory for Bone Metabolism, Xi’an Key Laboratory of Special Medicine and Health Engineering, Northwestern Polytechnical University, Xi’an 710072, ChinaLaboratory for Bone Metabolism, Xi’an Key Laboratory of Special Medicine and Health Engineering, Northwestern Polytechnical University, Xi’an 710072, ChinaLaboratory for Bone Metabolism, Xi’an Key Laboratory of Special Medicine and Health Engineering, Northwestern Polytechnical University, Xi’an 710072, ChinaCyclin-dependent kinases (CDKs) are a group of serine/threonine protein kinases and play crucial roles in various cellular processes by regulating cell cycle and gene transcription. Cyclin-dependent kinase 12 (<i>CDK12</i>) is an important transcription-associated CDK. It shows versatile roles in regulating gene transcription, RNA splicing, translation, DNA damage response (DDR), cell cycle progression and cell proliferation. Recently, increasing evidence demonstrates the important role of <i>CDK12</i> in various human cancers, illustrating it as both a biomarker of cancer and a potential target for cancer therapy. Here, we summarize the current knowledge of <i>CDK12</i>, and review the research advances of <i>CDK12</i>′s biological functions, especially its role in human cancers and as a potential target and biomarker for cancer therapy.https://www.mdpi.com/2073-4409/9/6/1483cyclin-dependent kinase 12gene transcriptioncell cyclecell proliferationDNA damage responsecancer therapy |
| spellingShingle | Shujing Liang Lifang Hu Zixiang Wu Zhihao Chen Shuyu Liu Xia Xu Airong Qian <i>CDK12</i>: A Potent Target and Biomarker for Human Cancer Therapy Cells cyclin-dependent kinase 12 gene transcription cell cycle cell proliferation DNA damage response cancer therapy |
| title | <i>CDK12</i>: A Potent Target and Biomarker for Human Cancer Therapy |
| title_full | <i>CDK12</i>: A Potent Target and Biomarker for Human Cancer Therapy |
| title_fullStr | <i>CDK12</i>: A Potent Target and Biomarker for Human Cancer Therapy |
| title_full_unstemmed | <i>CDK12</i>: A Potent Target and Biomarker for Human Cancer Therapy |
| title_short | <i>CDK12</i>: A Potent Target and Biomarker for Human Cancer Therapy |
| title_sort | i cdk12 i a potent target and biomarker for human cancer therapy |
| topic | cyclin-dependent kinase 12 gene transcription cell cycle cell proliferation DNA damage response cancer therapy |
| url | https://www.mdpi.com/2073-4409/9/6/1483 |
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