Decreased gray matter volume and dynamic functional alterations in medicine-free obsessive-compulsive disorder
Abstract Background Previous studies discovered the presence of abnormal structures and functions in the brain regions of patients with obsessive-compulsive disorder (OCD). Nevertheless, whether structural changes in brain regions are coupled with alterations in dynamic functional connectivity (dFC)...
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| Format: | Article |
| Language: | English |
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BMC
2023-04-01
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| Series: | BMC Psychiatry |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12888-023-04740-w |
| _version_ | 1797836369997856768 |
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| author | Zhenning Ding Zhipeng Ding Yunhui Chen Dan Lv Tong Li Tinghuizi Shang Jidong Ma Chuang Zhan Xu Yang Jian Xiao Zhenghai Sun Na Wang Wenbin Guo Chengchong Li Zengyan Yu Ping Li |
| author_facet | Zhenning Ding Zhipeng Ding Yunhui Chen Dan Lv Tong Li Tinghuizi Shang Jidong Ma Chuang Zhan Xu Yang Jian Xiao Zhenghai Sun Na Wang Wenbin Guo Chengchong Li Zengyan Yu Ping Li |
| author_sort | Zhenning Ding |
| collection | DOAJ |
| description | Abstract Background Previous studies discovered the presence of abnormal structures and functions in the brain regions of patients with obsessive-compulsive disorder (OCD). Nevertheless, whether structural changes in brain regions are coupled with alterations in dynamic functional connectivity (dFC) at rest in medicine-free patients with OCD remains vague. Methods Three-dimensional T1-weighed magnetic resonance imaging (MRI) and resting-state functional MRI were performed on 50 medicine-free OCD and 50 healthy controls (HCs). Firstly, the differences in gray matter volume (GMV) between OCD and HCs were compared. Then, brain regions with aberrant GMV were used as seeds for dFC analysis. The relationship of altered GMV and dFC with clinical parameters in OCD was explored using partial correlation analysis. Finally, support vector machine was applied to examine whether altered multimodal imaging data might be adopted to distinguish OCD from HCs. Results Our findings indicated that GMV in the left superior temporal gyrus (STG) and right supplementary motor area (SMA) was reduced in OCD, and the dFC between the left STG and the left cerebellum Crus I and left thalamus, and between the right SMA and right dorsolateral prefrontal cortex (DLPFC) and left precuneus was decreased at rest in OCD. The brain regions both with altered GMV and dFC values could discriminate OCD from HCs with the accuracy of 0.85, sensitivity of 0.90 and specificity of 0.80. Conclusion The decreased gray matter structure coupling with dynamic function in the left STG and right SMA at rest may be crucial in the pathophysiology of OCD. Trial registration Study on the mechanism of brain network in obsessive-compulsive disorder with multi-model magnetic resonance imaging (registration date: 08/11/2017; registration number: ChiCTR-COC-17,013,301). |
| first_indexed | 2024-04-09T15:07:43Z |
| format | Article |
| id | doaj.art-a9442c5b72874c6e8d1bb6d7e99e953d |
| institution | Directory Open Access Journal |
| issn | 1471-244X |
| language | English |
| last_indexed | 2024-04-09T15:07:43Z |
| publishDate | 2023-04-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Psychiatry |
| spelling | doaj.art-a9442c5b72874c6e8d1bb6d7e99e953d2023-04-30T11:23:35ZengBMCBMC Psychiatry1471-244X2023-04-012311910.1186/s12888-023-04740-wDecreased gray matter volume and dynamic functional alterations in medicine-free obsessive-compulsive disorderZhenning Ding0Zhipeng Ding1Yunhui Chen2Dan Lv3Tong Li4Tinghuizi Shang5Jidong Ma6Chuang Zhan7Xu Yang8Jian Xiao9Zhenghai Sun10Na Wang11Wenbin Guo12Chengchong Li13Zengyan Yu14Ping Li15Medical Technology Department, Qiqihar Medical UniversityMedical Technology Department, Qiqihar Medical UniversityDepartment of Psychiatry, Qiqihar Medical UniversityDepartment of Psychiatry, Qiqihar Medical UniversityDepartment of Psychiatry, Qiqihar Medical UniversityDepartment of Psychiatry, Qiqihar Medical UniversityDepartment of Psychiatry, Baiyupao Psychiatric Hospital of HarbinDepartment of Psychiatry, Baiyupao Psychiatric Hospital of HarbinMedical Technology Department, Qiqihar Medical UniversityDepartment of Psychiatry, Qiqihar Medical UniversityDepartment of Psychiatry, Qiqihar Medical UniversityDepartment of Psychiatry, Qiqihar Medical UniversityDepartment of Psychiatry, and National Clinical Research Center for Mental Disorders, The Second Xiangya Hospital of Central South UniversityDepartment of Psychiatry, Qiqihar Medical UniversityDepartment of Psychiatry, Qiqihar Medical UniversityDepartment of Psychiatry, Qiqihar Medical UniversityAbstract Background Previous studies discovered the presence of abnormal structures and functions in the brain regions of patients with obsessive-compulsive disorder (OCD). Nevertheless, whether structural changes in brain regions are coupled with alterations in dynamic functional connectivity (dFC) at rest in medicine-free patients with OCD remains vague. Methods Three-dimensional T1-weighed magnetic resonance imaging (MRI) and resting-state functional MRI were performed on 50 medicine-free OCD and 50 healthy controls (HCs). Firstly, the differences in gray matter volume (GMV) between OCD and HCs were compared. Then, brain regions with aberrant GMV were used as seeds for dFC analysis. The relationship of altered GMV and dFC with clinical parameters in OCD was explored using partial correlation analysis. Finally, support vector machine was applied to examine whether altered multimodal imaging data might be adopted to distinguish OCD from HCs. Results Our findings indicated that GMV in the left superior temporal gyrus (STG) and right supplementary motor area (SMA) was reduced in OCD, and the dFC between the left STG and the left cerebellum Crus I and left thalamus, and between the right SMA and right dorsolateral prefrontal cortex (DLPFC) and left precuneus was decreased at rest in OCD. The brain regions both with altered GMV and dFC values could discriminate OCD from HCs with the accuracy of 0.85, sensitivity of 0.90 and specificity of 0.80. Conclusion The decreased gray matter structure coupling with dynamic function in the left STG and right SMA at rest may be crucial in the pathophysiology of OCD. Trial registration Study on the mechanism of brain network in obsessive-compulsive disorder with multi-model magnetic resonance imaging (registration date: 08/11/2017; registration number: ChiCTR-COC-17,013,301).https://doi.org/10.1186/s12888-023-04740-wObsessive-compulsive disorderGray matter volumeResting-stateDynamic functional connectivity |
| spellingShingle | Zhenning Ding Zhipeng Ding Yunhui Chen Dan Lv Tong Li Tinghuizi Shang Jidong Ma Chuang Zhan Xu Yang Jian Xiao Zhenghai Sun Na Wang Wenbin Guo Chengchong Li Zengyan Yu Ping Li Decreased gray matter volume and dynamic functional alterations in medicine-free obsessive-compulsive disorder BMC Psychiatry Obsessive-compulsive disorder Gray matter volume Resting-state Dynamic functional connectivity |
| title | Decreased gray matter volume and dynamic functional alterations in medicine-free obsessive-compulsive disorder |
| title_full | Decreased gray matter volume and dynamic functional alterations in medicine-free obsessive-compulsive disorder |
| title_fullStr | Decreased gray matter volume and dynamic functional alterations in medicine-free obsessive-compulsive disorder |
| title_full_unstemmed | Decreased gray matter volume and dynamic functional alterations in medicine-free obsessive-compulsive disorder |
| title_short | Decreased gray matter volume and dynamic functional alterations in medicine-free obsessive-compulsive disorder |
| title_sort | decreased gray matter volume and dynamic functional alterations in medicine free obsessive compulsive disorder |
| topic | Obsessive-compulsive disorder Gray matter volume Resting-state Dynamic functional connectivity |
| url | https://doi.org/10.1186/s12888-023-04740-w |
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