Cardiac glycosides and COVID-19: would it be a promising therapeutic approach?
Abstract Cardiac glycosides have been found to have an anti-viral effect. This was noted in the past during various epidemics including MERS and SARS. It is due to their inhibitory effect on the Na, K-ATPase membrane pump. Furthermore, they exhibit anti-inflammatory properties. These preclinical obs...
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| Format: | Article |
| Language: | English |
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Academia Brasileira de Ciências
2020-10-01
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| Series: | Anais da Academia Brasileira de Ciências |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652020000700203&tlng=en |
| _version_ | 1818719789662601216 |
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| author | EFTYCHIOS SINIORAKIS SPYRIDON ARVANITAKIS MAXIMILIANOS ELKOURIS |
| author_facet | EFTYCHIOS SINIORAKIS SPYRIDON ARVANITAKIS MAXIMILIANOS ELKOURIS |
| author_sort | EFTYCHIOS SINIORAKIS |
| collection | DOAJ |
| description | Abstract Cardiac glycosides have been found to have an anti-viral effect. This was noted in the past during various epidemics including MERS and SARS. It is due to their inhibitory effect on the Na, K-ATPase membrane pump. Furthermore, they exhibit anti-inflammatory properties. These preclinical observations may prove useful in further clinical utility of these well-known compounds in the current COVID-19 pandemic. |
| first_indexed | 2024-12-17T20:12:32Z |
| format | Article |
| id | doaj.art-a94472e8633a499ca7978abb064dae7c |
| institution | Directory Open Access Journal |
| issn | 1678-2690 |
| language | English |
| last_indexed | 2024-12-17T20:12:32Z |
| publishDate | 2020-10-01 |
| publisher | Academia Brasileira de Ciências |
| record_format | Article |
| series | Anais da Academia Brasileira de Ciências |
| spelling | doaj.art-a94472e8633a499ca7978abb064dae7c2022-12-21T21:34:13ZengAcademia Brasileira de CiênciasAnais da Academia Brasileira de Ciências1678-26902020-10-0192410.1590/0001-3765202020201080Cardiac glycosides and COVID-19: would it be a promising therapeutic approach?EFTYCHIOS SINIORAKIShttps://orcid.org/0000-0002-6401-0326SPYRIDON ARVANITAKIShttps://orcid.org/0000-0001-5400-083XMAXIMILIANOS ELKOURIShttps://orcid.org/0000-0003-2689-4228Abstract Cardiac glycosides have been found to have an anti-viral effect. This was noted in the past during various epidemics including MERS and SARS. It is due to their inhibitory effect on the Na, K-ATPase membrane pump. Furthermore, they exhibit anti-inflammatory properties. These preclinical observations may prove useful in further clinical utility of these well-known compounds in the current COVID-19 pandemic.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652020000700203&tlng=enantiviral effectcardiac glycosidesCOVID-19 |
| spellingShingle | EFTYCHIOS SINIORAKIS SPYRIDON ARVANITAKIS MAXIMILIANOS ELKOURIS Cardiac glycosides and COVID-19: would it be a promising therapeutic approach? Anais da Academia Brasileira de Ciências antiviral effect cardiac glycosides COVID-19 |
| title | Cardiac glycosides and COVID-19: would it be a promising therapeutic approach? |
| title_full | Cardiac glycosides and COVID-19: would it be a promising therapeutic approach? |
| title_fullStr | Cardiac glycosides and COVID-19: would it be a promising therapeutic approach? |
| title_full_unstemmed | Cardiac glycosides and COVID-19: would it be a promising therapeutic approach? |
| title_short | Cardiac glycosides and COVID-19: would it be a promising therapeutic approach? |
| title_sort | cardiac glycosides and covid 19 would it be a promising therapeutic approach |
| topic | antiviral effect cardiac glycosides COVID-19 |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652020000700203&tlng=en |
| work_keys_str_mv | AT eftychiossiniorakis cardiacglycosidesandcovid19woulditbeapromisingtherapeuticapproach AT spyridonarvanitakis cardiacglycosidesandcovid19woulditbeapromisingtherapeuticapproach AT maximilianoselkouris cardiacglycosidesandcovid19woulditbeapromisingtherapeuticapproach |