Druggable cavities and allosteric modulators of the cell division cycle 7 (CDC7) kinase

Druggable cavities and allosteric modulators of the cell division cycle 7 (CDC7) kinase

Cell division cycle 7 kinase (CDC7) has been found overexpressed in many cancer cell lines being also one of the kinases involved in the nuclear protein TDP-43 phosphorylation in vivo. Thus, inhibitors of CDC7 are emerging drug candidates for the treatment of oncological and neurodegenerative unmet...

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Bibliographic Details
Main Authors:	Elisa Rojas-Prats, Loreto Martinez-Gonzalez, Carmen Gil, David Ramírez, Ana Martinez
Format:	Article
Language:	English
Published:	Taylor & Francis Group 2024-12-01
Series:	Journal of Enzyme Inhibition and Medicinal Chemistry
Subjects:	CDC7 DBF4 allosteric modulator virtual screening binding pockets
Online Access:	https://www.tandfonline.com/doi/10.1080/14756366.2024.2301767

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